Joined January 2018
I write a lot about Covid origins. I thought the lab leak theory made sense, back in 2020, but I eventually came to realize that it's very unlikely to be true. Here's a summary of some long posts I've written and many shorter threads:
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Note: i phrased that wrong — either of those amino acid changes could happen on their own, but G228S is unlikely because the change is from GGA to AGT/AGC, so 2 nucleotide change.
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But Q226L is a single nucleotide change, and that alone might be enough to bind the human receptors. Are we really just one nucleotide change away from a mink adapted virus spreading in people?
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Pigs also express a mix of both types of receptors, and are another potentially dangerous intermediate for that reason.
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Cows themselves appear to pose a fairly low pandemic risk (or, at least, we had 1,000 infected herds in America without causing a human pandemic). But the new mink data shows that unaddressed infection of cows can lead to infection of other animals which pose a higher risk.
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Bat sampling trip finds more relatives of SARS-CoV-2 in Thailand:
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Nature tries a large number of combinations across huge numbers of bats, and some of them happen to infect other animals. xitter.cf/PeterDaszak/status/211…
Replying to @PeterDaszak
With @CREID_Network funding formerly to EcoHealth Alliance & in collaboration w/ @ChulalongkornU @dukenus @ThaiRedCross & others, we sampled bats & people at Ratchaburi Cave 1 hr West of Bangkok where ~3million bats fly out every night & locals gather to watch the spectacle 4/
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Those bat viruses are always going to be present in nature, but the choices we make in how we farm and eat other animals will have a big impact in terms of whether we get another spillover of these viruses: xitter.cf/tgof137/status/2094906…
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