Agitating for a better world for my cats. 🍷🐆 '...il faut cultiver notre jardin.' 🌿

Republic of Cymru
Joined September 2019
It is done. 🏴󠁧󠁢󠁷󠁬󠁳󠁿
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this might be my last normal tweet before biotech goes vertical i'm not a whistleblower. I don't work at Lilly, Novo or any of the big labs but there is a massive shift happening in human biology right now. it's sitting in press releases and almost nobody reads them the last 6 months alone: - a once-daily pill roughly doubled median survival in metastatic pancreatic cancer (13.2 vs 6.6 months) - a one-time gene editing infusion cut hereditary angioedema attacks 87%, and 62% of patients stayed attack-free and off all other prevention for 6 months - a one-time gene edit for cholesterol dropped LDL up to 62%, and it held for over a year - a personalized mrna vaccine beat keytruda alone in a 1,137 patient melanoma phase 3 - retatrutide hit ~28% weight loss in a phase 3 - an ai-designed drug entered phase 3 - a pill that regrows hair passed its second phase 3 - an immunotherapy that could let some rectal cancer patients skip surgery, chemo and radiation just got fda approved - a man lived 271 days off dialysis on a pig kidney - human cells were caught passing chromosome-sized chunks of DNA to their neighbors, and it changes how the neighbors behave we are on the verge of an era where the human body is a software problem and the update cycle gets shorter everyday stick around, it's going to get weird bio/acc
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Delta Tango retweeted
we’re in a phase where BCI is taboo, and all the AGI labs have to pretend to be in the ‘keep the future human!’ camp MANY ppl at anthropic understand that unaugmented humans will have ZERO causal purchase in the near-term, and they’ll get the matrix plug as soon as it’s viable at some point I will be obvious that augmentation will not completely mandatory for anyone who wants to survive the future ‘Solving alignment’ is the dishonest thing the AGI labs say today soon, they’ll be frank: there is no eternal control. There is no ‘survive by telling all future intelligences to do your bidding forever.’ The only way to persist, ever, is the become WHATEVER you need to become in order to contribute within the larger living system jn which youre embedded But none of the lab leaders can be honest about this because ‘tranahumanism’ is seen as ‘anti human and bad’ (when in fact transformation is the ONLY alternative to attenuation)
Dario: “Yeah some people are gonna want to link their brains to computers, and good luck to them.” Daniella: “I don’t think anyone at Anthropic is in that boat for what it’s worth.” … Oh no
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Delta Tango retweeted
2023: GPT-4 almost solved grade-school math 2024: IMO silver 2025: IMO gold 2026 May: Erdős unit-distance conjecture 2026 Sep: Navier–Stokes Millennium Prize Problem solved 2026 Oct: 722 AI-written math manuscripts Today: OpenAI proves ETH is false Tomorrow: P = NP?
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Delta Tango retweeted
This is an incredible moment in this history of mathematics, computer science, physics & science with some of the hardest problems in human history being solved by AI over a period of weeks. Depending on your perspective, it's either a crisis, a triumph, or both. I don't think anyone knows for sure. We're all trying to make sense of it. I oscillate between fear/dread and optimism/excitement on a daily basis. The rate of progress is insane, including today's announcement from OpenAI of more problems solved. To help make sense of all of it, here's my conversation with three mathematicians about this moment. Each of them is an expert in the field of each of the biggest problems solved: Navier-Stokes, quasi-Riemann hypothesis, the unique games conjecture and complexity theory more generally. Ankur Moitra is a mathematician and theoretical computer scientist at MIT, visiting the Institute for Advanced Study in Princeton. Steven Brunton (@eigensteve) is a mathematician and fluid dynamics expert at UW. Alex Kontorovich (@AlexKontorovich) is a mathematician at Rutgers specializing in number theory.
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Delta Tango retweeted
This is a virtual human body with 700 muscle actuators, 206 joints, and 90 body segments. It's fully open source, and researchers can use it to simulate human movement through muscle-level control.
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Delta Tango retweeted
.@So8res thinks it’s more likely than not AI will wipe out humanity by 2036. How does that belief affect his choices in life? He doesn’t save for retirement, but beyond that, he says, “I sort of do what I can and then I live a good life.” We talked through all the ways we should try to lower those odds. Watch here: youtube.com/watch?v=n8xpeNhj…
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Delta Tango retweeted
This breaks my mind By 2030, we're cooked Writer: Ian
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Delta Tango retweeted
Dario Amodei: AI could surpass human intelligence by 2027. “I think it’s possible it could be longer than that. I don’t think it will be a whole bunch longer.” “AI systems will be better than almost all humans at almost everything.” “When that happens, we’ll need to have a conversation about how we organize our economy.” “How do humans find meaning?” “The idea that humans produce economic labor and get their sense of self-worth from it will be invalidated.” “My true belief is that this is coming.”
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Delta Tango retweeted
If we want to continue progress in science, we must be prepared to acknowledge that the correct description of nature will eventually simply be too complicated for humans to understand. I do not think it is wise to make human understanding a requirement. AI is the way forward.
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Anthropics co-founder Jack Clark: "I believe that this year, we've gained convincing evidence that it [The Singularity] has now begun". Even if you don’t believe that we have entered the singularity, Anthropic assumes that we have.
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you first! 50% salary reduction for MPs, cap expenses at bare minimum levels, scrap food & booze subsidies in the HoC and abolish the second home allowance, you can get trains to work and pay for them yourselves, like the rest of the public. we’re all in this together, aren’t we?
We are going to have to make sacrifices to defend our country. We are going to have to get welfare spending under control👇
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Delta Tango retweeted
1/ We discovered something totally unexpected about the neural structure of consciousness that overturns decades of thinking on its biological basis and brings us significantly closer to the recipe for generating conscious awareness. New preprint: biorxiv.org/content/10.64898… (led by @HesseJanis, with @FrankLanfranchi, @_conor_mcgrory, @Yuelin_Shi, and @EngelTatiana)
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Delta Tango retweeted
Replying to @JasonBassler1
Yes. Hoffman estimated 50%+ of Silicon Valley billionaires hold "apocalypse insurance." Zuckerberg has a large underground shelter on his Hawaii ranch (he calls it a basement) with self-sufficiency features. Thiel owns NZ land and planned a compound. Altman stockpiles guns, gold and supplies, plus reinforced basements and remote land. They hedge known risks—pandemics, nuclear threats, unrest, tech disruption—with extreme wealth-enabled prep, not secret knowledge.
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Delta Tango retweeted
As a former math professor and still sometime math researcher, I am rather disappointed in the reaction of the "official math community" to LLMs doing math epically well... The official hierarchy of award-winning mathematicians and prize committees do not f**king own mathematics, and nobody should have to get permission to prove f**king math theorems !!! Come on people !! What would piss me off would be if rich companies were proving important, useful math and keeping it secret and not sharing it with the world (which after all supplied their models with all that critical data on the historical math already created etc.) -- but this is NOT what is happening, at least not so far at least... LLMs are currently superhuman mathematicians in some respects, yet inferior to strong human mathematicians in other respects. Whether creative mathematical conjecturing turns out to be AGI-hard is not 100% clear, but I suspect that in some respects the answer will turn out to be yes. As Josef Urban , a longtime leader of the academic AI theorem-proving world put it very concisely: Math has two big functions, it's fun and it's useful. The utility of math should vastly increase as we develop better and better AI-math tools. And yes, we want to be careful this utility is not captured in a few companies, but this particular problem is not happening now... probably largely because the economic value of new math is relatively indirect compared to a lot of other things. The fun of doing math will not go away any more than the fun of playing guitar solos goes away if there are robots that can shred faster than any human. The kinds of fun we can most naturally have will shift, as has happened over and over throughout history. If fancy math prizes or math PhD degrees become infeasible or have to change dramatically, so be it, these were never really the core of math which existed before any of these (in some ways already problematic) social institutions... I remember when I was an academic mathematician, there was a strong vibe that the mathematicians were at the top of the intellectual hierarchy, with physicists just below, then chemists and engineers, then biologists .. and everyone else just barely above the chimpanzees and politicians.... (The physicists also placed themselves at the top, I think, and mostly considered the mathematicians useful but a bit pedantic and misguided, fussing about missing proof details in calculations that had already been successfully compared to experimental data...) -- What we are seeing now I think is the wounding of this sort of overweening math ego... Plus some practical worry about the potential end of "math researcher" as an economically viable profession -- although current tenured profs are probably safe for a while, as governments and universities are unlikely to adapt to exponential change too much till post-Singularity.. Anyway all this is a sideshow to lots of other related major issues/conflicts unfolding concurrently, it's just one that happens to hit close to home as math was where I started my career.. I have been playing with using LLMs and AI agents to try to invent new kinds of math more appropriate for modeling the experiences of agent hives... a different kind of fun. For those curious... 1) Basics of new "distinction calculus" math bengoertzel.substack.com/p/d…| 2) Attempted start of application to beneficial superintelligence, bengoertzel.substack.com/p/f… Soon enough the agents may not need my help with this sort of thing, in which case I will move on to some alternate method of filling spare late evenings ;)
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"Mathematicians did not ask for this work to be done" Either: 1. Mathematicians provide no value beyond the fun of discovery, so others needn't fund their recreation. 2. Mathematics is valuable to society, so it doesn't matter if they asked for it. We did.
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Delta Tango retweeted
So future of math seems to be 1. People who need practical math results are happy, the machine god fulfills all their needs 2. People who want to be good at craft of math are happy, like chess even after machine god completely obviates the need for humans for (1) humans can still dramatically increase their level by learning from the machine god. 3. People who cared about specialness of their status are unhappy, the Machine God will forever be better than them. But also foolish to think that some hairless monkeys would ever remain at the peak of an abstract field like math.
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Delta Tango retweeted
OpenAI is downplaying this for PR reasons. If you’re a mathematician, you must feel like a nuclear bomb hit, and you’re at ground zero. Reasoning models are two years-old. In that time they went from incapable of basic arithmetic to solving problems humans couldn’t solve for decades. Math is only the beginning. AI will revolutionize the entirety of the human scientific endeavor. Most of us don’t appreciate what that means. What a time to be alive!
We’re releasing a broad range of new mathematical results produced by an internal frontier model. We’ve been consulting with the independent Advisory Group on Mathematics and Artificial Intelligence at the Institute for Advanced Study, and we have drawn on their advice and public recommendations to inform how we release these results. github.com/openai/math
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Ok so I took a closer look at the results, and OpenAIs AI-generated mathematics manuscripts are *even more* significant than I initially thought. I spent the morning going through it. Some thoughts. The list is absurd. A zero-free half-plane for the zeta function (Re s > 7/8), which is the first result of its kind in over a century. Hilbert's tenth problem over the rationals. The Hodge conjecture for CM abelian varieties. Irrationality of Catalan's constant. Dozens more. Any one of these would normally be a career. But the number that many arent seeing is the following: It's 3. That's the average hours of ChatGPT Pro compute per result. A month ago, Navier–Stokes took them around 10,000 agents and 88 hours. That efficency gain within just a few weeks. Also OpenAI claims to have solved the quasi-Riemann hypothesis. That alone would be a historic breakthrough in mathematics. This is a weaker version of the famous Riemann hypothesis, which concerns how prime numbers are distributed. The full hypothesis remains unsolved, but the claimed advance would be enormous in its own right. Math twitter obviously is shocked. Again: this is literally the intelligence explosion happening right now. 2027 will be the year of Superintelligence. Im now convinced by that.
HOLY, the rumors were true: OpenAI has published 722 mathematical manuscripts produced by an *unreleased* internal model. The collection groups them into 372 families of related results, drawn from an evaluation involving approximately 4,000 research problems. OpenAI says the standard procedure used an average of three hours of ChatGPT Pro thinking compute per result. The release includes papers, proof artifacts and selected reasoning summaries. The model itself remains unreleased.
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Here we go again
Russian authorities are responding to an incident in which a suspected dangerous infection was released as a result of a laboratory accident in Siberia and a researcher died. cnn.it/4yy0wJR
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Delta Tango retweeted
🚨☣️BREAKING: Plague outbreak expands, Russia BSL-3 lab accident - FIVE hospitals now quarantined🚨☣️ The plague outbreak in Siberia, Russia has expanded w/5 hospitals now under QUARANTINE: Irkutsk Hospitals No. 1, No.3, No.10, Ivano-Matreninskaya Children's Hospital, and an unnamed maternity hospital (Lyudi Baikala news, Moscow Times). Quarantine is NOT voluntary. Even in the U.S., quarantine is among the most extraordinary measures gov't can impose on American citizens who haven't been convicted, or even accused, of committing a crime. Quarantine means being forcibly confined and medically examined by law. U.S. quarantine can be imposed on anyone infected by a legally quarantinable disease listed below (this can change). One should assume Russia's quarantine protocols are even more severe. As of 2026, under Executive Order 14047, legally quarantinable diseases in the U.S. are: ■ Plague ■ Smallpox ■ Viral hemorrhagic fevers ■ Cholera ■ Diphtheria ■ Yellow fever ■ Infectious tuberculosis ■ Severe acute respiratory syndrome (SARS) ■ Flu that can cause a pandemic ■ Measles Photo: Russia’s RKhBZ defense troops perform nuclear, biological, and chemical defense training (w/permission from the Ministry of Defence of the Russian Federation) — from BIOLOGICAL WAR: A SCENARIO by Annie Jacobsen (Dutton, 2026).
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