@therealRYC

PGY-4 @UW Psychiatry. Prev MD-PhD @WUSTL. Biomarker and drug discovery for psychiatry, starting with Schizophrenia. Dog Daddy x2 to Taro and Azuki.

 Seattle, WA
Joined February 2020
  • Tweets4.4K
  • Following865
  • Followers4.1K
1.1KMedia

Who Started It? The Physics of Why Relationships Get Stuck

“I only nag because he shuts down.”

Article · @therealRYC
1
492

The Muscarinic Bet, Two Years On

Last week, MapLight Therapeutics announced that its muscarinic agonist ML-007C-MA met the primary endpoint of its Phase 2 trial in schizophrenia. Patients on the twice-daily dose improved by 11.7 poin…

Article · @therealRYC
2
2
3
5
3,035

The Professional Patient: Why Psychiatric Drug Trials Keep Failing

There's a secret hiding in plain sight in drug discovery in psychiatry.

Article · @therealRYC
6
4
3
27
5,146

The Only Article You Need to Be Informed on SSRIs in Pregnancy

A 2025 FDA advisory panel reviewed SSRI safety in pregnancy. ACOG issued a statement. SMFM issued a statement. Commentators took sides. Social media caught fire.

Article · @therealRYC
11
11
5
32
11,514

Why You Think You Have ADHD

Your coworker just got diagnosed. Your college roommate swears she's had it all along. Your partner watched a TikTok and now he's "pretty sure" he has it too.

Article · @therealRYC
4
9
7
38
31,862

Interpreting Psychedelic Trial Readouts Like a Psychiatrist

Helus Pharma ($HELP, formerly known as Cybin but rebranded due to avoiding a pure "psychedelic" association) dropped topline data this week from the Phase 2 signal-detection study of HLP004, their deu…

Article · @therealRYC
2
9
3,107

How to Disagree Productively in the Age of Polarization

Society has become polarized.

Article · @therealRYC
490

Will GLP-1s Treat Alzheimer's Disease?

In just two weeks (December 3 at 5:05 pm PST), @novonordisk will be revealing results from the evoke and evoke+ trials, what the company has called its "lottery ticket" to clawing back its fumbled mar…

Article · @therealRYC
5
5
2
24
10,480

Ketamine in a Bit of a Hole

This week, a bombshell paper published in JAMA Psychiatry found Ketamine no more effective than a benzodiazepine in treating depression. Why then, are ketamine and its enantiomeric cousin esketamine s…

Article · @therealRYC
6
11
2
52
8,969

Is There a Brain Signature of Mental Illness?

If mental health stems for the brain, where is the smoking gun? Unlike neurological disorders where a single lesion can lead to crippling deficits that can be reliably mapped back to a specific area o…

Article · @therealRYC
5
4
3
11
5,534

A Revisionist History of the DSM-5

The Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) does not have many friends. Psychiatrists view it as a lumbering, imperfect, laundry list of symptoms clustered into ar…

Article · @therealRYC
2
1
14
4,757

This Week in Psychiatry - Ep. 9

Welcome back to This Week in Psychiatry!

Article · @therealRYC
1
2
1
5
1,800
Load more