@tim__cherry

Principal investigator in Seattle studying non-coding contributions to Central Nervous System development and vision. All statements are my own.

Joined June 2016
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Join us for the Seattle Walk to End Hydrocephalus, 9am Sept. 20 at Magnuson Park. Organized by the Hydrocephalus Association, that has supported our research into genetic causes of hydrocephalus and potential therapeutic targets. You can also donate at support.hydroassoc.org/goto/…
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If you're looking for an incredibly supportive environment with great science and fantastic colleagues, please apply! Even as a basic researcher, I really appreciate that our work fits into the overall mission here to help kids live longer, happier and healthier lives.
David Beier@DavidBeier152 Oct 2023
The Center for Developmental Biology and Regenerative Medicine in the Seattle Children’s Research Institute, affiliated with the U of Washington, seeks outstanding scientists. Areas of interest are any relevant to human disease and development. jobs.sciencecareers.org/job/…

Assistant, Associate, or Full Professor, Center for Developmental Biology and Regenerative Medicine...

Seeking qualified candidates for the Assistant, Associate, or Full Professor position in CDBRM at Seattle Children's Research Institute.

jobs.sciencecareers.org
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Pls RT! We are hiring RAs & postdocs to study pericyte function and neurovascular coupling mechanisms in physiology & dementia pathology. *Funded positions! *Join a fantastic team! *Live in beautiful Portland, OR! tinyurl.com/MishraLabRA tinyurl.com/MishraLabPD DM/email for info.
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Our newest biorxiv manuscript and first academic-industry collaboration. Lots of hard-work by lab superstars Cheri Chambers, Abbi Engel, and Gillan Soo! Also a big thanks to the vision of Paolo Martini and Andrea Frassetto at @moderna_tx ! biorxiv.org/content/10.1101/…

Lipid nanoparticle-mediated delivery of mRNA into the mouse and human retina and other ocular...

Purpose Lipid nanoparticles (LNPs) show promise in their ability to introduce mRNA to drive protein expression in specific cell types of the mammalian eye. Here, we examined the ability of mRNA...

biorxiv.org
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We also see LNP-delivered mRNA expression in cornea, iris, iridocorneal angle, and perivascular cells, all disease relevant tissues.
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It's our hope that these studies add to the toolbox of therapeutic vectors for ophthalmic conditions and provide additional genetic access for basic research into retinal biology.
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Great collaborative paper out from the Eade and Wiseman labs, led by @jessica_rosarda . We uncovered the mechanism of toxicity behind a common lipid defect that leads to degenerative eye disease. @LabWiseman @NatureComms doi.org/10.1038/s41467-023-3…

Imbalanced unfolded protein response signaling contributes to 1-deoxysphingolipid retinal toxicity

Nature Communications - The accumulation of cytotoxic deoxysphingolipids causes retinopathies through unknown mechanisms. Here the authors use retinal organoids to show that photoreceptor toxicity...

nature.com
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Replying to @elfridedebaere
@elfridedebaere is presenting our latest work on comparative 3D genome analyses in the neural retina and RPE @UKEyeGenetics Stay tuned for the preprint!
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We are recruiting-looking for creative and collaborative investigators to join a growing program. Our interests are broad. Please RT. Assistant, Associate, or Full Professor, Center for Developmental Biology and Regenerative Medicine jobs.sciencecareers.org/job/…

Assistant, Associate, or Full Professor, Center for Developmental Biology and Regenerative Medicine...

Seeking qualified candidates for the associate or assistant professor position in CDBRM at Seattle Children's Research Institute.

jobs.sciencecareers.org
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Dear PhD students, You should reach out to labs you are interested in for postdocs even if they do not specifically advertise! There are many funding opportunities out there even if your paper is still under review/in BioRXiv.
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What if you could image cells in fixed tissue sections, choose which ones to sequence 🔬, and then return to the same cells after NGS? Light-Seq⚡️🧬: high-res spatial sequencing of cells in fixed tissue for directly linking imaging + NGS + protein stains! nature.com/articles/s41592-0…
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Great mentoring, great science, and great environment. Apply now!!!
Kimberly Aldinger, PhD@kaaldinger30 Jun 2022
My lab (officially) opens its doors @seattlechildren August 1st! Our team of 3 with an active collaborative network is looking to expand! Interested in early (mostly brain) development and disease etiology? Join our team: bit.ly/3a3GEIp bit.ly/3nshZQT
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This has been an incredible opportunity to stay at the forefront of neuroscience, make connections, and learn. Highly recommend!
allen institute@AllenInstitute8 Jun 2022
⭐️ Now accepting applications for Next Generation Leaders. This program fosters the development of emerging and diverse leaders in #neuroscience and recognizes the importance of their fresh and innovative perspectives. ⭐️ Learn more & apply by July 28: alleninstitute.org/what-we-d…
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A shout-out to Dr. Leah VandenBosch @MsCephalopod in our lab for receiving the Helen Juanita Reed Award and fellowship from @_BrightFocus AND for her recent manuscript tvst.arvojournals.org/articl… predicting the effects of variants within non-coding regulatory regions of the retina...
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This paper now out in TVST predicts the effect of non-coding variants on retinal enhancer and promoter function using an SVM-based machine learning approach developed by M Beer and colleagues but trained with human retinal epigenomic data.
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Lead by Leah VandenBosch this was an inspiring collaboration with co-author @KelseyTLuu and tremendous contributions from @timmo2003, Yue Wu, and @aaronylee! Our hope is that this work can continue to develop as a powerful resource. Reach out with questions and suggestions!
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Timothy Cherry @tim__cherry, Aaron Lee @aaronylee et al @seattlechildren use human retinal epigenomic data to train a machine learning model for predicting the impact of non-coding regulatory sequence variants in retinal disease. doi.org/10.1167/tvst.11.4.16
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It’s the first day of Spring already?! I better change out of my sweatpants and put on something pink. 🌱 🌸
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Are you a young scientist wanting to understand causes of abnormal brain development, help people w rare genetic conditions, learn molecular biology/bioinformatics, and live in Seattle? Then we have a job for you! DM for more info or apply at bit.ly/3CWIrJfRS1pos Pls retweet!
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