Tim Huddy (@tim_huddy) profile picture

Tim Huddy

@tim_huddy
Joined September 2022
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Photo by Tim Huddy (@tim_huddy)Photo by Tim Huddy (@tim_huddy)
Our latest paper highlights the advancements achieved in the past couple of years in the realm of self-assembling de novo polyhedral polyhedras. We delve into the cutting-edge methodologies, including first principle- & AI-based approaches, that enable their precise engineering.
ChemBioChem (@ChemBioChem) profile pictureChemBioChem@ChemBioChem18 Jul 2023
De Novo Design of Polyhedral Protein Assemblies: Before and After the AI Revolution (Khmelinskaia et al.) @akhmelinlab #OpenAccess chemistry-europe.onlinelibra…
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Hierarchical design of pseudosymmetric protein nanoparticles biorxiv.org/cgi/content/shor… #bioRxiv
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Geometrically standardized features give @LEGO_Group blocks their ability to be intuitively assembled into structures. Here we show that designed proteins can be made to a similar standard, enabling useful features in nanomaterials such as scalable size: biorxiv.org/content/10.1101/…
Blueprinting expandable nanomaterials with standardized protein building blocks

Blueprinting expandable nanomaterials with standardized protein building blocks

A wooden house frame consists of many different lumber pieces, but because of the regularity of these building blocks, the structure can be designed using straightforward geometrical principles. The...

biorxiv.org
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We use parameterized placement of straight alpha helices to construct standardized protein modules.
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These modules can be combined by geometric principles to make unique nanomaterials, such as nanocages with scalable size. Thanks to our many collaborators within and outside of @UWproteindesign
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