Vaccinologist at A*STAR ID Labs in Singapore using microfluidics to characterize antibodies and antigens against viruses and other infectious diseases.
Singapore
Joined July 2010
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Matthew Tay retweeted
Matthew Tay presents an overview of his lab’s research on characterizing coronavirus antigenic landscapes and using mutation analysis and prediction to develop broadly acting antivirals. @idlabs_astar
Matthew Tay retweeted
#Chikungunya: A growing public health crisis😷 With >120,000 cases, 51 deaths in 2023; 46 in #Paraguay. This study used a suite of genomic, phylodynamic, and epidemiologic techniques to characterize the ongoing large chikungunya epidemic in Paraguay.👉doi:10.3201/eid2909.230523
Is it a tall order to do biologic therapeutics discovery, Pk analysis, and meta-analysis of 2000 studies to show its importance in treatment? This is one of the SCI-PHI projects built at @nuspharmacydept by 6 ambitious undergrads - proud to be one of their mentors.
#NUSPharmacy
Resonated: “Something that's really tough for people in the USA to really understand is that in Singapore, you can have 40, 50-year plans. So you can really do some amazing things. Whereas in the US, you're always thinking about two-year election cycles.”
forbes.com/sites/juergeneckh…
science.org/content/article/…
mAbs among the approaches for protecting us against the next pandemic. But can we generate mAbs that protect not just against sarbecoviruses or betacoronaviruses, but also all other coronaviruses?
#Coronavirus #SARSCoV2
COVID-19 increased antibody responses against all orrhocoronaviruses, albeit at low levels. How does this affect our protection against additional zoonotic coronaviruses?
medrxiv.org/content/10.1101/…
#tayterthoughts #SARSCoV2
ACE2 decoys (but not Spike-directed peptides) are broad neutralizers of SARS-CoV-2. But they may need to be tuned to increase their in vivo efficacy.
journals.asm.org/doi/full/10…
#tayterthoughts #SARSCoV2 #Omicron
229E coronavirus:
Spike takes ~8 years to mutate 1%
RBD takes 2 years to mutate 1%(journals.plos.org/plospathog…)
SARS-CoV-2:
Spike takes 1 year to mutate 1%
RBD takes 4 months to mutate 1%
(calculated based on WT, BA2, XBB1.5)
SARS-CoV-2 mutates 6-8x faster.
#tayterthoughts
Machine learning and language models may be able to predict future SARS-CoV-2 variants. What biological (ACE2 affinity/immune escape parameters) or epidemiological data inputs are required to train good models?
pubmed.ncbi.nlm.nih.gov/3344…
pubmed.ncbi.nlm.nih.gov/3501…
#tayterthoughts
Memory B cells are selected based on low affinity to antigen, i.e. failure to continue in the germinal center, in order to preserve cross-reactivity to different pathogen variants.
pubmed.ncbi.nlm.nih.gov/3312…
pubmed.ncbi.nlm.nih.gov/2715…
pubmed.ncbi.nlm.nih.gov/3517…
#tayterthoughts
I’m #hiring! Looking to do antibody-based therapeutics against infectious disease, including potentially AACs. See our website and contact for details :) antimicrobialbiologicslabora…
