@willjnathan

Postdoc in the Nussenzweig lab at NCI/NIH | DPhil from @UniofOxford via @NIHOxCam interested in DNA repair, cancer, and aging

 Washington DC
Joined November 2023
  • Tweets13
  • Following61
  • Followers11
William Nathan retweeted
Peter J Park@peter_j_parkSep 5
On biorxiv this week: "Integrated map of somatic mosaicism across human tissues in 25 individuals" from the Somatic Mosaicism across Human Tissues Network (biorxiv.org/content/10.64898…)
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William Nathan retweeted
Cell@CellCellPressSep 9
Now online! Caloric restriction modulates genome-wide somatic mutation in mice dlvr.it/TVPkH2
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William Nathan retweeted
Science Magazine
@ScienceMagazineSep 7
A psychedelic compound best known for its effects on the brain may help prevent one of chemotherapy's most debilitating side effects—chemotherapy-induced peripheral neuropathy, researchers report in Science. In mouse models, as few as two doses of psilocybin given before treatment durably prevented CIPN through multiple cycles of chemotherapy, while preserving both nerve function and the therapies’ tumor-killing effects. 📄: scim.ag/4ctTNaF #SciencePerspective: scim.ag/466LJcj
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William Nathan retweeted
Cell@CellCellPressJul 3
Now online! Recurrent patterns of TOP1-mediated neuronal genomic damage shared by major neurodegenerative disorders dlvr.it/TTLSXz

Recurrent patterns of TOP1-mediated neuronal genomic damage shared by major neurodegenerative...

Single-cell whole-genome sequencing reveals a shared pattern of excessive somatic mutations across C9ORF72 ALS, C9ORF72 FTD, and Alzheimer’s disease, dominated by 2-bp deletions. These mutations...

cell.com
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William Nathan retweeted
Cell@CellCellPressJun 11
Now online! DNA repair drives cisplatin-induced neuronal death dlvr.it/TT03lc

DNA repair drives cisplatin-induced neuronal death

In neurons, cisplatin-induced DNA damage is repaired by NER, but low dNTP pools cause NER to promote death rather than survival. Deoxynucleoside supplementation or genetic upregulation of dNTP...

cell.com
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Why does cisplatin treatment cause neurons to die? We identify that too much DNA repair exhausts the low level of dNTPs in neurons and drives cisplatin neurotoxicity. From @nussenza lab. Thanks to our many great collaborators on this work! Check it out: cell.com/cell/fulltext/S0092…

DNA repair drives cisplatin-induced neuronal death

In neurons, cisplatin-induced DNA damage is repaired by NER, but low dNTP pools cause NER to promote death rather than survival. Deoxynucleoside supplementation or genetic upregulation of dNTP...

cell.com
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Implications of this work lies in reducing cisplatin-induced peripheral neuropathy, a harmful cisplatin side effect. Increasing dNTP levels is a potential strategy to reduce cisplatin side effects in the nervous system and possibly other post-mitotic tissues.
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Ribonucleotide-associated indels in CTE! Unclear why ssIndels aren’t repaired…or maybe MMR/another pathway doesn’t know which strand is correct and sometimes creates the dsIndel. Cool study science.org/doi/10.1126/scie…

Diverse somatic genomic alterations in single neurons in chronic traumatic encephalopathy

Chronic traumatic encephalopathy (CTE) is a neurodegenerative disease linked to exposure to repetitive head impacts (RHI), yet little is known about its pathogenesis. Applying two single-cell...

science.org
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Interesting. Curious to see the follow-ups showing what exactly CIRBP does in DSB repair. nature.com/articles/s41586-0…

Evidence for improved DNA repair in the long-lived bowhead whale

Nature - Analysis of the longest-lived mammal, the bowhead whale, reveals an improved ability to repair DNA breaks, mediated by high levels of cold-inducible RNA-binding protein.

nature.com
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My lab has been working for the past 15 years to develop a method to isolate specific genomic loci to identify its chromatin composition & protein interactome. Finally,… our superb physician/scientist Dr. Bercin Cenik @bkcenik did it and here it is cell.com/molecular-cell/full… Not only was she able to develop this method, which she calls TurboCAS, she was able to identify known & novel regulators of heat shock & Myc expression. Cannot wait to see what Bercin and TurboCAS will discover about the molecular basis of transcriptional regulation with great impact on clinic in the next few years! @NU_BMG_SQE @NUFeinbergMed @MolecularCell
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William Nathan retweeted
Cell@CellCellPress17 Sep 2024
Now online! In vivo DNA replication dynamics unveil aging-dependent replication stress dlvr.it/TDMNkz

In vivo DNA replication dynamics unveil aging-dependent replication stress

In vivo DNA replication dynamics in regenerating mouse livers unveil aging-dependent decline in replication efficiency and a crucial role of the ATR checkpoint kinase in mitigating inflammation...

cell.com
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William Nathan retweeted
nature
@Nature24 Apr 2024
Nature research paper: Chemoproteomic discovery of a covalent allosteric inhibitor of WRN helicase go.nature.com/3UgWdj5

Chemoproteomic discovery of a covalent allosteric inhibitor of WRN helicase

Nature - VVD-133214, a clinical-stage, covalent allosteric inhibitor of the helicase WRN, was well tolerated in mice and led to robust tumour regression in multiple microsatellite-instability-high...

nature.com
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William Nathan retweeted
nature
@Nature25 Apr 2024
Nature research paper: Discovery of WRN inhibitor HRO761 with synthetic lethality in MSI cancers go.nature.com/4dfngDV
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