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トンヌラ

@37phoenix

へっぽこ内科医。なんちゃって感染症専門医。論文メモ。

 Japan
Joined November 2011
  • Tweets4.9K
  • Following160
  • Followers2.2K
23Media
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COVID-19、非COVID-19の市中肺炎に対する免疫調整治療の効果。COVID-19に対するステロイド、サイトカイン阻害、JAK阻害薬は死亡率の低下と関連。SR&MA. Clin Microbiol Infect. PMID: 42994614. pubmed.ncbi.nlm.nih.gov/4299…
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PJPに対して低用量STは効果があり、安全か。Editorial. Clin Microbiol Infect. PMID: 42994613. pubmed.ncbi.nlm.nih.gov/4299…
Is a lower dose of trimethoprim sulfamethoxazole for Pneumocystis jirovecii pneumonia just as...

Is a lower dose of trimethoprim sulfamethoxazole for Pneumocystis jirovecii pneumonia just as...

Is a lower dose of trimethoprim sulfamethoxazole for Pneumocystis jirovecii pneumonia just as effective, but safer?

pubmed.ncbi.nlm.nih.gov
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脳梗塞、TIA既往のある患者へのSBP<120の強化降圧療法は<140と比較して心血管死亡、非致死性心筋梗塞、非致死性脳卒中、狭心症や心不全による入院の複合アウトカムのリスクが低かったHR 0.67-0.94。OPTIMAL-STROKE. Gisele Sampaio. N Engl J Med. NEJMoa2612924. nejm.org/doi/full/10.1056/NE…
Intensive Blood-Pressure Control in Patients with Previous Ischemic Stroke | NEJM

Intensive Blood-Pressure Control in Patients with Previous Ischemic Stroke | NEJM

Whether intensive blood-pressure control reduces cardiovascular risk after cerebrovascular events remains uncertain. In this multicenter, open-label, randomized trial conducted at 30 sites in Brazi...

nejm.org
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２型糖尿病患者でのSBP<120の降圧目標は<140と比較して主要心血管イベントを減らさなかった。4年間のフォローアップ。重篤な有害事象も変わらず。OPTIMAL-DIABETES. Karla Santo. N Engl J Med. nejm.org/doi/full/10.1056/NE…
Intensive Blood-Pressure Lowering in Patients with Type 2 Diabetes | NEJM

Intensive Blood-Pressure Lowering in Patients with Type 2 Diabetes | NEJM

Uncertainty persists regarding the effects of intensive blood-pressure lowering in patients with type 2 diabetes. In this multicenter, open-label, randomized trial conducted in Brazil, patients wit...

nejm.org
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カルバペネマーゼ産生腸内細菌目細菌に対するβラクタマーゼ阻害薬配合薬のreview. Clin Microbiol Rev. PMID: 42992797. pubmed.ncbi.nlm.nih.gov/4299…
Innovative β-lactams and β-lactam/β-lactamase inhibitor combinations against carbapenemase-produc...

Innovative β-lactams and β-lactam/β-lactamase inhibitor combinations against carbapenemase-produc...

SUMMARYThe global dissemination of carbapenemase-producing Enterobacterales (CPE) represents one of the most pressing threats to modern antimicrobial therapy. The rapid worldwide expansion of these...

pubmed.ncbi.nlm.nih.gov
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全身MRIスクリーニングの診断的有用性。検査を受けた人の78％に１つ以上の異常が報告されたが、臨床的意義は不明である。J Gen Intern Med. PMID: 42823587. pubmed.ncbi.nlm.nih.gov/4282…
The Diagnostic Yield of Whole-Body MRI as a Multi-disease Screening Modality: A Systematic Review...

The Diagnostic Yield of Whole-Body MRI as a Multi-disease Screening Modality: A Systematic Review...

Not applicable.

pubmed.ncbi.nlm.nih.gov
206
重症患者における高血糖の管理。BMJ Open Diabetes Res Care. 2026;14:e006533. PMID: 42933867. pubmed.ncbi.nlm.nih.gov/4293…
Management of dysglycemia in critically ill adults: current evidence, clinical practice and future...

Management of dysglycemia in critically ill adults: current evidence, clinical practice and future...

Hyperglycemia is among the most common metabolic disturbances in critically ill patients, affecting up to 50% of adults admitted to intensive care units (ICUs), regardless of pre-existing diabetes....

pubmed.ncbi.nlm.nih.gov
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心臓内デバイス感染やIEの原因としての腸球菌の増加。Review. Am J Med. PMID: 42998800. pubmed.ncbi.nlm.nih.gov/4299…
Enterococci as Emerging Pathogens in Infective Endocarditis and Cardiac Device Infections: Future...

Enterococci as Emerging Pathogens in Infective Endocarditis and Cardiac Device Infections: Future...

Enterococci are emerging as important pathogens in an era of an aging population with high healthcare and antibiotic exposure, along with an increasing utilization of prosthetic valves, transcatheter...

pubmed.ncbi.nlm.nih.gov
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下痢を引き起こす大腸菌の病原型. Review. Clin Microbiol Infect. PMID: 42994615.　pubmed.ncbi.nlm.nih.gov/4299…
Pathovars of Escherichia coli associated with diarrhoea - which, when and how to treat them - PubMed

Pathovars of Escherichia coli associated with diarrhoea - which, when and how to treat them - PubMed

Routine testing for EPEC, EAEC, and ETEC is rarely warranted. As molecular assays cannot distinguish EIEC from Shigella spp. and routine culture does not reliably identify EIEC, treatment should be...

pubmed.ncbi.nlm.nih.gov
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エビデンスより習慣。整形外科的人工物感染に対するリファンピシン。Olivia Mobarakai. Antibiotics.2026;15:1098. mdpi.com/4178854
More Habit than Hard Evidence? Rifampin in Orthopedic Implant Infections: A Practical Guide for...

More Habit than Hard Evidence? Rifampin in Orthopedic Implant Infections: A Practical Guide for...

Orthopedic implant infections—including prosthetic joint infections (PJI), fracture-related infections (FRI), and spinal implant infections (SII)—represent a spectrum of biofilm-associated infections...

mdpi.com
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英国とスコットランドにおける予防的抗菌薬投与のガイドラインの違いとIEによる入院患者の比較。英国では2008年のガイドライン改定後予防的抗菌薬投与が93％減少し、IEの入院患者が112％増加した。Martin H Thornhill. Lancet Regional Health Europe. thelancet.com/journals/lanep…
Changes in antibiotic prophylaxis prescribing and infective endocarditis admissions in England and...

Changes in antibiotic prophylaxis prescribing and infective endocarditis admissions in England and...

Although our data do not establish causality, they suggest that cessation of AP may be followed by a significant increase in IE-admissions compared with policies recommending AP for high-risk...

thelancet.com
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院内の敗血症患者においてアセトアミノフェンの投与は抗菌薬投与の遅れや体温の推移とは関連しなかった。J Hisp Med. PMID: 42117581. pubmed.ncbi.nlm.nih.gov/4211…
Associations between paracetamol administration and delayed intravenous antibiotic administration...

Associations between paracetamol administration and delayed intravenous antibiotic administration...

In this study, paracetamol administration before a sepsis alert was not associated with a delay in antibiotic administration and did not affect temperature changes.

pubmed.ncbi.nlm.nih.gov
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ヒト感染症における細胞内の黄色ブドウ球菌。Review. Lancet Microbe. PMID: 42976895. pubmed.ncbi.nlm.nih.gov/4297…
Intracellular Staphylococcus aureus in human infections: evidence from clinical specimens - PubMed

Intracellular Staphylococcus aureus in human infections: evidence from clinical specimens - PubMed

Staphylococcus aureus is a major human pathogen causing extensive morbidity and mortality. In vitro and animal studies show that S aureus can invade and survive within host cells. Such intracellular...

pubmed.ncbi.nlm.nih.gov
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安定した冠動脈疾患で中等度から高度な虚血を有する患者において初期侵襲的治療は薬物療法のみと比較して10年の長期全死因死亡率を改善しなかった。ISCHEMIA-EXTEND. JAMA. PMID: 42998244. pubmed.ncbi.nlm.nih.gov/4299…
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非カルバペネマーゼ産生カルバペネム耐性腸内細菌目細菌の治療を探る. Editorial. Michael j Satlin. Open Forum Infect Dis. 2026:ciag698 .PMID:42974662. pubmed.ncbi.nlm.nih.gov/4297…
Searching for the Optimal Treatment of Infections due to Non-Carbapenemase-Producing Carbapenem-r...

Searching for the Optimal Treatment of Infections due to Non-Carbapenemase-Producing Carbapenem-r...

Searching for the Optimal Treatment of Infections due to Non-Carbapenemase-Producing Carbapenem-resistant Enterobacterales

pubmed.ncbi.nlm.nih.gov
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脳神経障害のreview. Neurol Clin Pract. PMID: 42804727. pubmed.ncbi.nlm.nih.gov/4280…
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抵抗性高血圧症のケア。Review. J Am Coll Cardiol. 2026. PMID: 42831847. pubmed.ncbi.nlm.nih.gov/4283…
Optimizing Blood Pressure Care in Patients With Resistant Hypertension: 2026 ACC Expert Consensus...

Optimizing Blood Pressure Care in Patients With Resistant Hypertension: 2026 ACC Expert Consensus...

Optimizing Blood Pressure Care in Patients With Resistant Hypertension: 2026 ACC Expert Consensus Decision Pathway: A Report of the American College of Cardiology Solution Set Oversight Committee

pubmed.ncbi.nlm.nih.gov
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MSSA菌血症の重症患者に発症したセファゾリン関連凝固障害。Dakota Sicignano. Antimicrob Steward Healthc epidemiol. 2026;e320. cup.org/4zwbZKo
Cefazolin-associated coagulopathy in a critically Ill patient with MSSA bacteremia: a case report |...

Cefazolin-associated coagulopathy in a critically Ill patient with MSSA bacteremia: a case report |...

Cefazolin-associated coagulopathy in a critically Ill patient with MSSA bacteremia: a case report - Volume 6 Issue 1

cambridge.org
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成人の無症候性動脈硬化症の有病率. 頸動脈、大腿動脈の3D超音波や冠動脈CTで検査。18〜29歳の男8.7%、女性6.7%で動脈硬化を認めた。N Engl J Med. 2026;395:1818. PMID: 42670946.　pubmed.ncbi.nlm.nih.gov/4267…
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麻疹のreview. Ann Intern Med. PMID: 42970799. pubmed.ncbi.nlm.nih.gov/4297…
Measles - PubMed

Measles - PubMed

Measles is reemerging, with cases and outbreaks increasing across the United States and other countries where measles had previously been eliminated. Most U.S. physicians have no experience with...

pubmed.ncbi.nlm.nih.gov
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