HFSP fellow in Deisseroth lab @Stanford. Vision, circuits, cell types. All-optical experiments in cortex.
Stanford, CA
Joined July 2018
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What if we could watch AND control thousands of individual neurons in behaving mice—with stable access over months? 🧠⚡ Our new preprint introduces transgenic all-optical tools that make this possible - and a resulting surprising discovery! 🔭💡
biorxiv.org/content/10.1101/… 1/13 🧵
Antonia Drinnenberg retweeted
Our new paper on large scale holographic read-write experiments observing and controlling thousands of neurons in mouse visual cortex reveals a new functional cell-type that detects even moderate levels of excess activity (just 50 extra neurons firing) then inhibits top down cortical inputs.
This cell type is a subclass of somatostatin neurons, whose dysfunction is implicated in schizophrenia.
This suggests an intriguing hypothesis for the origins hallucinations in schizophrenia: the breakdown of this highly sensitive cortical gate allows top down inputs to enter visual cortex that should not, creating hallucinations.
This work was expertly lead by @ADrinnenberg w/ @allanraventos and @Alex_Attinger on data analysis and theory. Another fun collab w/ @KarlDeisseroth!
For more see: biorxiv.org/content/10.1101/…
And also this excellent thread: xitter.cf/ADrinnenberg/status/19…
What if we could watch AND control thousands of individual neurons in behaving mice—with stable access over months? 🧠⚡ Our new preprint introduces transgenic all-optical tools that make this possible - and a resulting surprising discovery! 🔭💡
biorxiv.org/content/10.1101/… 1/13 🧵
Amazing collaboration with @AllenInstitute team—@HongkuiZeng, @BosiljkaTasic, Tanya L. Daigle, La'Akea Siverts—to develop new transgenics for all-optical neuroscience.
And deeply grateful to @KarlDeisseroth for his support and mentorship. 🙏
12/13
We'll be at #SfN2025 ✨!
🗓️📍Come visit our late-breaking abstract poster on Sunday morning: LBP020.05/LBP041
13/13
Antonia Drinnenberg retweeted
✨New preprint✨ Ever dreamed of combining brain-wide fUS imaging, two-photon imaging, ephys, and optogenetics in mice during your favorite head-fixed task? Want to also capture their facial expressions? We present the COMBO window to facilitate all these techniques!
The COMBO window: A chronic cranial implant for multiscale circuit interrogation in mice biorxiv.org/cgi/content/shor… #biorxiv_neursci
Antonia Drinnenberg retweeted
We’re excited to extend noninvasive optogenetics beyond the brain to address a nearly 150-year-old question in a new study out today @Nature:
nature.com/articles/s41586-0…
Work led by @HsuehBrian, myself, and @KarlDeisseroth, with an amazing team in the D-lab and many others!
Thank you @SLBconference! I really enjoyed participating and am looking forward to the next SLB meeting already.
Antonia Drinnenberg retweeted
Excited to share a method for precise whole-gene knockin in the short-lived African turquoise killifish!!!
Such a fun project with @ClaireBedbrook Rahul Nagvekar @KarlDeisseroth @Brunetlab!!!!
Rapid and precise genome engineering in a naturally short-lived vertebrate biorxiv.org/cgi/content/shor… #bioRxiv
Antonia Drinnenberg retweeted
The Sylwestrak Lab is hiring! We have an open position for a research assistant in beautiful Eugene, OR. Great opportunity to gain lab experience in a variety of neuroscience approaches, both cellular/molecular and systems-level analyses. Check us out: sylwestraklab.com/openpositi…
