@APNeuro

Neuroscientist seeking to understand our mind #NARSAD Young Investigator @SNUnow @Columbia @ZuckermanBrain @Penn

 Seoul, Korea
apneuro.snu.ac.kr
Joined January 2021
  • Tweets167
  • Following157
  • Followers284
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Dynamic Interplay between Prefrontal Theta and Beta Bursts Facilitates Flexible Learning doi.org/10.5607/en25034 #neuroscience

Dynamic Interplay between Prefrontal Theta and Beta Bursts Facilitates Flexible Learning

Hahyeon Park, Haseong Kim, Eunyoung Yeo and Alan Jung Park. Exp Neurobiol 2025;34:263-76. https://doi.org/10.5607/en25034

en-journal.org
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Rapid, biochemical tagging of cellular activity history in vivo biorxiv.org/content/10.1101/…

Rapid, biochemical tagging of cellular activity history in vivo

Intracellular calcium (Ca2+) is ubiquitous to cell signaling across all biology. While existing fluorescent sensors and reporters can detect activated cells with elevated Ca2+ levels, these approac...

biorxiv.org
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A new paper from our lab, together with a short thread: rdcu.be/dHh9B
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New paper online! In 2018, we found a human brain signal that tracks real time fluctuations in mood/anxiety. Now Adam Jackson back-translates this biomarker to mice, dissects its circuit mechanisms, & tests its causal relationship to emotional state. 🧵1/6 authors.elsevier.com/sd/arti…
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New tools from my lab. Due to Minju Jeong's extensive efforts to validate the tools and Jun-Hyeok Choi's ingenious molecular design, we can now present additional methods to identify and modulate specific neuronal populations. cell.com/neuron/fulltext/S08…

Viral vector-mediated transgene delivery with novel recombinase systems for targeting neuronal...

Jeong et al. created a new viral technique, ΦC31/pSIO vector, to target specific neuronal cell types without cross-reactivity with Cre and Flp recombinases. These easy-to-use viral tools for robust...

cell.com
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Alan Park retweeted
Frances Xia@_fxia24 Oct 2023
Check out our new preprint on neural signatures of stress susceptibility and resilience in the amygdala-ventral hippocampal network! biorxiv.org/content/10.1101/… Thread below 👇

Neural signatures of stress susceptibility and resilience in the amygdala-hippocampal network

The neural dynamics that underlie divergent anhedonic responses to stress remain unclear. Here, we identified neuronal dynamics in an amygdala-hippocampal circuit that distinguish stress resilience...

biorxiv.org
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New paper from lab: A VPA-induced mouse model of ASD shows dysregulation of Wnt signaling through upregulation of RNF146 in PFC. rdcu.be/didwW Great team efforts with @joonomics, Drs. Min-Sik Kim and Chan Young Shin. Congrats @gogogaeun0624 and all authors!
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Happy to share this latest work, with @Kurt_Fraser and @TriciaJanak 🧵 jneurosci.org/content/43/21/…

From Prediction to Action: Dissociable Roles of Ventral Tegmental Area and Substantia Nigra...

Reward seeking requires the coordination of motor programs to achieve goals. Midbrain dopamine neurons are critical for reinforcement, and their activation is sufficient for learning about cues,...

jneurosci.org
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✨Exciting news! Our research on parallel decision computations is just out in @NatureNeuro ! nature.com/articles/s41593-0… With it, here goes my first attempt at a #tweetprint ! 🧵
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Neurogliaform cells dynamically decouple neuronal synchrony between brain areas science.org/doi/10.1126/scie…

Neurogliaform cells dynamically decouple neuronal synchrony between brain areas

Input selection in brain neuronal networks involves a local inhibitory cell that can decouple neuronal synchrony selectively and temporarily.

science.org
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Alan Park retweeted
David@dav1dcg3 Nov 2022
Dual-polarity voltage imaging of the concurrent dynamics of multiple neuron types Article: science.org/doi/10.1126/scie… Awesome!
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trent@Sheffield_Lab4 Nov 2022
1/18 Our paper on reward expectation, spatial encoding, and dopamine inputs to CA1 is finally out! Huge shout out to co-first authors twitterless postdoc Seetha Krishnan and grad student Chad Heer and our former lab tech Chery Cherian. nature.com/articles/s41467-0…
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We have a study out today on a new circuit that encodes information about reward that I am very excited to share from Twitterless lead author Wenliang Zhou. Time for a Tweet walk science.org/doi/10.1126/scia… 1/20
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Very happy to announce the publication of my first first-author paper in @CellReports! We find that ramping and phasic dopamine neuron activity reflect reward prediction error, improving goal-directed navigation. Thread (1/8) 👇 cell.com/cell-reports/fullte…

Midbrain dopamine neurons signal phasic and ramping reward prediction error during goal-directed...

Dopamine neurons signal reward prediction error in their phasic activity, but reports of ramping activity and its potential function remain controversial. Using experimental and computational...

cell.com
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Our preprint examining hippocampal dynamics during learning is up biorxiv.org/content/10.1101/… Interested in learning? Information processing by neural ensembles? Division of function across subnetworks? The hippocampus? Come along for a quick look at some highlights… 1/n

Population dynamics underlying associative learning in the dorsal and ventral hippocampus

Animals associate cues with outcomes and continually update these associations as new information is presented. The hippocampus is crucial for this, yet how neurons track changes in cue-outcome...

biorxiv.org
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Proud to be a part of a group that just published in @Nature a role for CCR5 in closing the temporal window for linking memories by modulating excitability and memory ensemble overlap. Also, CCR5 increases account for age-related loss in memory linking! tinyurl.com/bvv835wh
CCR5 modulates memory ensemble overlap

ALT CCR5 modulates memory ensemble overlap

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(1/8) Delighted to announce our new results on medial frontal cortex’s role in performance monitoring and cognitive control! Neurons formed domain-general representations of errors, conflict, and conflict probability, while preserving task-specific info. science.org/doi/10.1126/scie…
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Alan Park retweeted
Neuralynx@Neuralynx22 Mar 2022
Decoding the Performance of a #Memory Task Using Single-trial Intracranial EEG. doi.org/10.1109/BCI53720.202…
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Finally happy to unveil my postdoctoral paper on its final form, done under the guidance of @kaymtye and in colab with @BatraKanha @Cewu_Lu A few highlights: -A new dominance assay for mice -A new tool, AlphaTracker, to track multiple animals 1/n
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🚨Happy to announce that recordings of all parts of our recent Miniscope Workshop are now available here, sites.google.com/metacell.us…. This included updated talks on Miniscope assembly, use, & analysis along w/ outsiding talks by external speakers! Thanks to @MetaCell for hosting!

2021 Virtual Miniscope Workshop

sites.google.com
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