Lab of Adaptive Immunity at the Institute of Molecular Genetics of the ASCR.
Prague, Czech Republic
Joined August 2018
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I am honored to be interviewed by @J_Cell_Sci.
tinyurl.com/mpwcc43x
Ondrej Stepanek - Lab of Adaptive Immunity retweeted
Poslali jsme @RobertPlaga otevřený dopis, ve kterém ho vyzýváme k vyjádření ohledně budoucí podpory programu ERC CZ. Tento program je asi to nejlepší, co pro vědce v českém VaVaI existuje a pomáhá i při získávání evropských peněz v následných ERC callech.
vedazije.cz/clanek/clanek-fv…
Ondrej Stepanek - Lab of Adaptive Immunity retweeted
Saturday Spotlight💫: Presenting the first mouse model of #AddisonsDisease: doi.org/10.1172/jci.insight.…
Arina Andreyeva @AndreyevaAri, @ondrejStepanek, @AdaptiveImmuni2, et al., explore how immune cells destroy the adrenal glands in Addison's disease, identifying IFNG as a promising target for future therapies.🧵
Our latest study and second cover in our lab history.
Presenting the first mouse model of #AddisonsDisease: doi.org/10.1172/jci.insight.…
This issue’s Cover features work from Arina Andreyeva @AndreyevaAri, @ondrejStepanek, @AdaptiveImmuni2, et al., reporting on how immune cells destroy the adrenal glands in Addison's disease and identifying IFNG as a promising target for future therapies.
The cover image shows an adrenal section from a mouse with experimental autoimmune adrenalitis five months after immunization with CYP11A1-derived peptides. Granulomatous lesions appear as green due to intrinsic autofluorescence. Nuclei (DAPI, blue); steroidogenic adrenocortical cells (CYP11A1, red).
Ondrej Stepanek - Lab of Adaptive Immunity retweeted
Presenting the first mouse model of #AddisonsDisease: doi.org/10.1172/jci.insight.…
This issue’s Cover features work from Arina Andreyeva @AndreyevaAri, @ondrejStepanek, @AdaptiveImmuni2, et al., reporting on how immune cells destroy the adrenal glands in Addison's disease and identifying IFNG as a promising target for future therapies.
The cover image shows an adrenal section from a mouse with experimental autoimmune adrenalitis five months after immunization with CYP11A1-derived peptides. Granulomatous lesions appear as green due to intrinsic autofluorescence. Nuclei (DAPI, blue); steroidogenic adrenocortical cells (CYP11A1, red).
Our latest study is out! We developed and characterized the first defined mouse model of autoimmune Addison's disease and found that the pathology depends on IFNgamma.
insight.jci.org/articles/vie…
Ondrej Stepanek - Lab of Adaptive Immunity retweeted
@biorxivpreprint Distinct activation programs in naive and memory CD8 T cells govern progeny stemness and effector persistence @AdaptiveImmuni2
biorxiv.org/content/10.64898… 🇨🇿
Ondrej Stepanek - Lab of Adaptive Immunity retweeted
IFNG-producing self-reactive CD4+ T cells induce autoimmune adrenalitis in a mouse model of Addison’s disease @JCI_insight
insight.jci.org/articles/vie…
Ondrej Stepanek - Lab of Adaptive Immunity retweeted
@biorxivpreprint T cells restrain inflammation driven by TNF-induced cell death
biorxiv.org/content/10.64898… @PeterDraberLab @DIB_UNIL 🇨🇿🇨🇭
An immunocompromised man with neuroinvasive West Nile virus received donor derived virus specific T cells.
West Nile targeted T cells appeared in blood and MRI lesions improved, suggesting immune therapy may help fight persistent infection.
thelancet.com/journals/laneu…
Our beloved Cytek Aurora cytometer (*2019) is dead—electronics burned out. Does anyone have an unused/broken Aurora that could be a donor for the electronic guts transplantation? Please retweet.
We are happy that we could contribute a little bit to this story. The collaboration goes on and is funded by Czech Science Foundation #GACR.
NKG2A inhibition promotes NK cell-CD8+ T cell interactions to improve anticancer immunity in ovarian carcinoma @NatureComms @JitkaFucikova @SOTIO 🇨🇿
nature.com/articles/s41467-0…
There was some progress in the Czech science in the last decade(s), but still a lot of work needs to be done to make it on par with scientifically developed countries. Still many Czech science generals have no clue about what good science means.
The ERC's new white paper examines the gap in participation and success rates between Europe’s strongest research systems and a group of countries performing less well. It also calls for coordinated efforts at national and European level.
Read more: erc.europa.eu/news-events/ne…
Final week to register.
I would like invite you to @EFIS_Immunology - sponsored 14th Tatra Immunology conference, this time in Mikulov, Czechia in June. A great line up of speakers. The registration including food and accommodation only 600 EUR with a possibility of fellowships.
tatra.img.cas.cz/
Looking forward to welcome Martin at @imgprague soon.
🥁 New Latinx in Dev Bio interview!
From Argentina to the world 🌎 Martín Estermann shares his journey, research & next step: launching his own lab at the Czech Academy of Sciences. @EstermannMartin
Read more: sites.google.com/view/latinx…
#LatinxInSTEM #DevBio #NewPI
Ondrej Stepanek - Lab of Adaptive Immunity retweeted
The same western blot image used 23 times in 14 different papers by one Japanese team. The image has been labelled as representing a range of experiments and proteins. This is the most I have ever seen. Perhaps it is a record?
14th EFIS-EJI Tatra Immunology Conference
Since there are still a few spots left, we extended the registration deadline to March 15. Don't miss this reboot of the legendary conference series that formed generations of immunologists in (central) Europe.
tatra.img.cas.cz/program/
Ondrej Stepanek - Lab of Adaptive Immunity retweeted
AI is cool and all... but a new paper in @ScienceMagazine kind of figured out the origin of life?
The paper reports the discovery of a simple 45-nucleotide RNA molecule that can perfectly copy itself.
Ondrej Stepanek - Lab of Adaptive Immunity retweeted
Nominations now open for the 2026/2027 Vaccine Young Investigator Program (YIP)
sciencedirect.com/journal/va…
Ondrej Stepanek - Lab of Adaptive Immunity retweeted
🚀Open PhD position!
Ever wondered how cells polarize during early development?
This PhD project dives into how mechanochemically-driven cell polarization evolves.
🧪 Genomics
🔬Biophysics
📊Fitness analysis
Hooked?
🧡APPLY NOW img.cas.cz/phd
With @TeijeMiddelkoop
Ondrej Stepanek - Lab of Adaptive Immunity retweeted
Thanks to Lotte Pedersen and Esben Lorentzen for having great time, cilialicious discussions, and opportunity to present our research on #BardetBiedlSyndrome @imgprague in Copenhagen @UCPH_Research
