Deczkowska (@ADeczk) Lab for Brain-Immune Communication at Institut Pasteur. Untangling how body instructs the brain (choroid plexus FTW).

Joined May 2020
Brain-Immune Communication Lab retweeted
A massive global review just confirmed it. Clinical trials + real-world data from 132 million people across the globe. The HPV vaccine doesn’t just reduce cervical cancer. It almost eliminates it. Yes, you read that right. Girls vaccinated before 16 have an 80% lower risk of cervical cancer. Not a small reduction. Not “maybe.” Eighty percent. The protection isn’t only for the cervix. HPV causes cancers of the anus, penis, vagina, vulva, mouth, throat - the vaccine blocks the virus before the damage ever starts. This isn’t one study. It’s Cochrane, the gold standard of independent science. They analyzed clinical trials + real-world data from 132 million people across the globe. Not pharma PR. Not a lab press release. Global. Independent. Verified. The #1 fear? Side effects. Here’s what the data says: Arm soreness? Sure. Serious complications? No evidence. Rare side effects? Same rate as unvaccinated people. Translation: social media invented the danger. Cochrane couldn’t find it. Lawsuits against HPV vaccines? Courts dismissed claims as “speculative inferences.” Translation: conspiracy theories don’t hold up under evidence. Meanwhile, cervical cancer kills 350,000 women every year. Mostly young women. Mostly preventable. We don’t need more fear. We need more vaccination. And yes - boys should get the vaccine too. HPV doesn’t only cause cancer in women. Vaccinating boys protects everyone. Some countries are on track to eliminate HPV cancers entirely. Others are falling behind because misinformation spreads faster than vaccines. That shouldn’t be our legacy. We already have the tool to end cervical cancer. Not reduce it. End it. The only thing standing in the way is fear. Science isn’t asking for blind trust. It’s showing its receipts. Stop sharing rumors. Start preventing cancer.
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Brain-Immune Communication Lab retweeted
Australia just recorded zero cervical cancer cases in women under 25 - for the first time since records began in 1982. This is what happens when a country commits to HPV vaccination and screening. We protect our girls and save lives.
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Brain-Immune Communication Lab retweeted
Stress-induced sympathetic hyperactivation drives hair follicle necrosis to trigger autoimmunity: @CellCellPress cell.com/cell/fulltext/S0092…
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Brain-Immune Communication Lab retweeted
It’s no secret that we do our best work when it's less like work and more like a joy. That’s what we have in mind for Woodstock Night Science. The idea is to have the most fun conference possible so that good ideas flow and we all get inspired. That's needed now more than ever!
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Brain-Immune Communication Lab retweeted
Pyrolysis gas chromatography-mass spectrometry reveals the presence of micro- and nanoplastics in human kidney, liver, and brain tissue samples from 2016 and 2024, with higher proportions found in the brain nature.com/articles/s41591-0…
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Brain-Immune Communication Lab retweeted
#WeekendRead! #LipidPower! Hugues &co show @NatureComms that lymphatic endothelial cells modify cholesterol into oxysterols, blocking PPARg in intratumor macrophages & monocytes, making them more inflammatory thus potentiating anti-tumor T cell responses!! nature.com/articles/s41467-0…
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Brain-Immune Communication Lab retweeted
Our latest paper on neuronal resilience. The apoptotic pathway is activated as a transient pulse in neurons even with continuous apoptotic stimulus. Neurons prepare for survival even when they activate apoptotic signaling. Congrats Keeley and others!! nature.com/articles/s41418-0…
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Brain-Immune Communication Lab retweeted
❇️ Ce 22 octobre, l’Institut illumine ses bâtiments en vert pour soutenir le syndrome Phelan-McDermid (PMS), un trouble génétique associé à un retard du développement et à l’autisme. Les recherches sur SHANK3 ouvrent la voie à des essais cliniques prometteurs. 💚 #ShineGreen
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Brain-Immune Communication Lab retweeted
Corning now offers sterile tips that come in a paper container, thus generating less plastic waste!
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Brain-Immune Communication Lab retweeted
Neuropeptide signalling orchestrates T cell differentiation @Nature nature.com/articles/s41586-0…
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Brain-Immune Communication Lab retweeted
These findings are from a study in @NatureNeuro which identified common genetic variants that affect rates of brain growth or atrophy in the first genome-wide association meta-analysis of changes in brain morphology across the lifespan. nature.com/articles/s41593-0… 2/9
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Brain-Immune Communication Lab retweeted
An important study by F. Eun-Hyung Lee's team shows that long lived plasma cells (the source of long-term circulating antibodies) fail to establish after mRNA vaccination (even combined with SARS-CoV-2 infection). 🧵 (1/) nature.com/articles/s41591-0…
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Brain-Immune Communication Lab retweeted
Does the brain change during pregnancy? You bet it does. How about doing 26 MRI scans on a single person pre-conception to 2 years post-partum. WOW! Laura Pritschet and colleagues nailed it with their new paper in @NatureNeuro. Key Points: - The authors point out that pregnancy is a period of profound hormonal and physiological changes. - The authors did something incredible by mapping neuroanatomical changes in an individual from preconception through two years postpartum. - Boom! There were pronounced decreases in gray matter volume and cortical thickness. - There were increases in white matter microstructural integrity, ventricle volume and cerebrospinal fluid. - There were few regions untouched by the 'transition to motherhood.' My take: This study shows us how a single brain in a single person can be a powerful resource when scanned serially over time. This method is hard to pull off, however what it has the potential to teach us about neuroscience is mind-blowing. Though this paper is only a single subject, the data provides a comprehensive map of the human brain across gestation. It will be interesting to add to the dataset, so we can understand changes across multiple persons and multiple conditions. The convergence of evidence is revealing that pregnancy as associated with dramatic neuroplasticity. How about a shout out to this 38-year-old woman who underwent 26 MRI scans along with blood draws from 3 weeks preconception through 2 years postpartum! nature.com/articles/s41593-0… #pregnancy #brain @ndosenbach @andreashorn_ @EMiddlebrooksMD
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Brain-Immune Communication Lab retweeted
For nearly 2 decades, Alzheimer’s disease (AD) “genome-wide” association studies only covered the autosomes. Today we unveil the X chromosome and prioritize SLC9A7, a.k.a. NHE7, as an AD risk gene. Article: jamanetwork.com/journals/jam… Editorial: jamanetwork.com/journals/jam…
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Brain-Immune Communication Lab retweeted
Inhibition of colorectal cancer in Alzheimer’s disease is mediated by gut microbiota via induction of inflammatory tolerance pnas.org/doi/10.1073/pnas.23…
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Brain-Immune Communication Lab retweeted
Calling all emerging scientists - it’s time to send us an application! 😉😎 Lead your own #MaxPlanck Research Group w/ €2.7M in funding over 6 yrs, full independence & resources to hire staff. State-of-the-art infrastructure awaits you!🌟 Apply today➡️mpg.de/career/max-planck-res…
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Brain-Immune Communication Lab retweeted
Boom! Cerebrospinal fluid (CSF) flow extends to peripheral nerves. Alexander Ligocki, Ed Scott and colleagues @UF @UFHealth blow our minds. New paper @ScienceAdvances. What will we call it now? Cerebro-spinal-nerve fluid (CSNF)? or maybe brain-spinal-nerve fluid (BSN)? Just when you think you have a few ground truths of the brain and nervous system, you are humbled again. Key Points: - The authors point out that dogma holds that cerebrospinal fluid is responsible for 'maintaining brain homeostasis through nutrient delivery and waste removal for only the central nervous system.' - They show extensive CSF flow throughout the peripheral nervous system. - They traced multimodal 1.9-nanometer gold nanoparticles. - These nanoparticles were roughly the size of CSF circulating proteins. - They squirted them into the lateral cerebral ventricle. -They showed incredibly that the particles transitioned from central to peripheral nervous systems at root attachments and transition zones. - They showed the particles could make it all the way to the axoplasm of distal peripheral nerves. - Bigger 15-nanometer gold particles were not able to make the journey. My take: We know that the nervous system does not contain the more traditional lymphatics and has a force field called the blood brain barrier. We know that CSF delivers nutrients and removes waste from the brain and central nervous system. Our previous ground truth was established by studies using dye tracers. Using small gold nanoparticles these authors 'tore down the dogma.' So the real question is whether it is time for a name change? Cerebrospinal fluid (CSF) or cerebro-spinal-nerve fluid (CSNF)? or maybe brain-spinal-nerve fluid (BSN)? Thoughts? Sartor resartus – the tailor re-tailored our view on this important aspect of neuroscience. BRAVO! science.org/doi/10.1126/scia… #parkinson #CSF #cerebrospinal #Alzheimers
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