@AvrahamLab

Investigating the cell biology of proteostasis and misfolded proteins in neurological disorders. Associate Prof. at Tel Aviv University.

 Tel Aviv University
ashkenazilab.com/
Joined May 2019
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  • Followers461
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Our paper published online in @Brain1878. We identify a cancer-associated #ubiquitin enzyme as a potential therapeutic target in #Huntington's disease. @TAUMedFaculty @of_sagol academic.oup.com/brain/artic…

Targeting UCHL3 attenuates pathological markers in neuronal models of Huntington’s disease

Ishtayeh et al. identify the cancer-associated deubiquitinating enzyme UCHL3 as a potential therapeutic target in Huntington’s disease. Genetic and pharmac

academic.oup.com
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🎉Our review ia out in press #Autonomic nervous system dysfunction in #development: Dissecting PHOX2B-Dependent Mechanisms in CCHS Across Experimental Models. @of_sagol @TAUMedFaculty @GVatine academic.oup.com/ajrcmb/arti…

Dissecting PHOX2B-Dependent Mechanisms in CCHS Across Experimental Models

Abstract. Congenital central hypoventilation syndrome (CCHS) is a rare autonomic nervous system disorder characterized by defective autonomic control of br

academic.oup.com
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ONLINE NOW: Deubiquitinases at organelle quality control bottlenecks in neurodegeneration dlvr.it/TStKxH
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Our new review is online🙂: Deubiquitinases at organelle quality control bottlenecks in #neurodegeneration: @TrendsMolecMed @of_sagol cell.com/trends/molecular-me…
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Read the full paper here (free access): authors.elsevier.com/a/1nDJ1…
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Together with Lisa Ellerby (Buck Institute), we discuss our recent Brain paper (academic.oup.com/brain/artic…) in a broader context.

Targeting UCHL3 attenuates pathological markers in neuronal models of Huntington’s disease

Ishtayeh et al. identify the cancer-associated deubiquitinating enzyme UCHL3 as a potential therapeutic target in Huntington’s disease. Genetic and pharmac

academic.oup.com
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Avraham Ashkenazi retweeted
Nat Rev Neurology@NatRevNeurolApr 22
New online! Extracellular matrix remodelling in neurological diseases dlvr.it/TS9YvF
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Eran Meshorer@meshorer1Apr 15
Why do pathogenic variants in the same gene lead to different neurodevelopmental outcomes? Check out the new Shifman / Meshorer labs collaborative review in TiG @TrendsGenetics , lead by our amazing joint student, Elad Dvir👇👇👇 sciencedirect.com/science/ar…
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Elegant study on that fit the unconventional secretion mode of TMEM16F: Lipid scrambling via TMEM16F mediates the formation and release of extracellular vesicles | Molecular Biology of the Cell molbiolcell.org/doi/10.1091/…

Lipid scrambling via TMEM16F mediates the formation and release of extracellular vesicles |...

The ubiquitous and highly conserved programmed cell death pathways that are essential for tissue development and homeostasis are accompanied by distinct morphological alterations. Apoptotic cells...

molbiolcell.org
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Avraham Ashkenazi retweeted
Nature Rev Neurosci@NatRevNeurosciMar 4
Mitochondrial dynamics in neurodevelopment and neurodevelopmental disorders — a Review by Carissa L. Sirois, Jiyoun Lee, Audrey L. Chambers & Xinyu Zhao nature.com/articles/s41583-0…

Mitochondrial dynamics in neurodevelopment and neurodevelopmental disorders

Nature Reviews Neuroscience - Mitochondria make essential contributions to neural development. Zhao and colleagues provide an overview of the mechanisms that regulate mitochondrial biogenesis,...

nature.com
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Avraham Ashkenazi retweeted
tommaso patriarchi@tpatriarchiFeb 26
The most sensitive green and red #norepinephrine #sensors engineered to date are out in @naturemethods! Deeply grateful to all our funders and contributors who made this work possible. A true team effort. @ERC_Research @snsf_ch @UZH_en @UZH_IPT doi.org/10.1038/s41592-026-0…

Next-generation multicolor indicators for in vivo imaging of norepinephrine

Nature Methods - Improved red and green indicators for norepinephrine and their characterization are reported. These indicators allow detection of norepinephrine release in awake behaving mice in...

nature.com
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Stochastic misfolding drives the emergence of distinct α-synuclein strains: Neuron cell.com/neuron/fulltext/S08…
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Elegant work. Congratulations to Julie and team. #Parkinson's disease #alpha-synuclein secretion
Julie Jacquemyn@JacquemynJulieFeb 14
So excited to share our work on Glucosylceramide-induced ectosomes propagate pathogenic alpha-synuclein in Parkinson’s disease, now out @ Nature Cell Biology! @NaturePortfolio nature.com/articles/s41556-0…
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Check our new work @NatRevMCB . It was fun working with Gali Prag on this piece. Stay tuned for more research on this exciting topic from our lab. Thanks 🙏 to referee and editor for the feedback @of_sagol @TelAvivUni
Nature Reviews Molecular Cell Biology@NatRevMCBFeb 20
New Online! The emerging importance of UBA6 in ubiquitylation and proteostasis dlvr.it/TR4B8m

The emerging importance of UBA6 in ubiquitylation and proteostasis

Nature Reviews Molecular Cell Biology - Ubiquitination is traditionally viewed as a one-E1 system based on UBA1, but accumulating evidence positions the related UBA6 as a distinct...

nature.com
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Avraham Ashkenazi retweeted
Guillaume Laconde@Glaconde34Feb 20
PROTAC-Mediated Degradation of mHTT Aggregates Attenuates Neurotoxicity in Cellular and R6/2 Mouse Models of Huntington’s Disease | Journal of the American Chemical Society pubs.acs.org/doi/10.1021/jac…

PROTAC-Mediated Degradation of mHTT Aggregates Attenuates Neurotoxicity in Cellular and R6/2 Mouse...

Abstract. Huntington’s disease (HD) is a fatal neurodegenerative disorder caused by an expanded CAG repeat in the HTT gene, producing mutant huntingtin (mH

pubs.acs.org
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Our article commentary is out in @NatRevMCB. 🎉 Together with Gali Prag, we discuss the emerging functions of the #ubiquitin enzyme UBA6 in health and disease. @of_sagol @taumed nature.com/articles/s41580-0…
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Free access link to the paper: rdcu.be/e4U3Y
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Stay tuned for more research from our lab on this exciting topic!
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We are excited to announce that the Parkinson’s Foundation and @ACSMNews, the world’s largest sports medicine and exercise science organization, have announced updated recommendations to provide safe and effective guidance on exercise for people with Parkinson’s disease. The updated exercise recommendations were published following extensive review from subject matter experts, as well as members of the PD community who actively use the recommendations. Read more: Parkinson.org/about-us/news/…
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Congratulations Edward and team :beautiful work.
Avezov lab@AvezovLFeb 13
New from our lab: FidlTrack—structure-aware single-particle tracking benchmarks/boost SPT fidelity It resolves in organelles e.g. BACE1 amyloidogenic APP cleavage #Alzheimers, ER exit, map nanobody binding in realtime in ER/organelles 🔬🧠#SingleMolecule rdcu.be/e3Ris
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The consequences of this mechanism for prion-like aggregate spreading need to be explored. Congratulations! Nice.
Nature Chemical Biology@nchembioFeb 19
A new paper reveals that adhesion GPCRs promote extracellular vesicle (EV) formation and EVs spread GPCRs into neighboring cells to activate G-protein signaling, providing a novel mechanism for cell-cell communication nature.com/articles/s41589-0…
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