Investigating the cell biology of proteostasis and misfolded proteins in neurological disorders. Associate Prof. at Tel Aviv University.
Tel Aviv University
Joined May 2019
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Avraham Ashkenazi retweeted
ONLINE NOW: Deubiquitinases at organelle quality control bottlenecks in neurodegeneration dlvr.it/TStKxH
Avraham Ashkenazi retweeted
New online! Extracellular matrix remodelling in neurological diseases dlvr.it/TS9YvF
Avraham Ashkenazi retweeted
Why do pathogenic variants in the same gene lead to different neurodevelopmental outcomes?
Check out the new Shifman / Meshorer labs collaborative review in TiG @TrendsGenetics , lead by our amazing joint student, Elad Dvir๐๐๐
sciencedirect.com/science/arโฆ
Avraham Ashkenazi retweeted
Mitochondrial dynamics in neurodevelopment and neurodevelopmental disorders โ a Review by Carissa L. Sirois, Jiyoun Lee, Audrey L. Chambers & Xinyu Zhao
nature.com/articles/s41583-0โฆ
Avraham Ashkenazi retweeted
The most sensitive green and red #norepinephrine #sensors engineered to date are out in @naturemethods! Deeply grateful to all our funders and contributors who made this work possible. A true team effort. @ERC_Research @snsf_ch @UZH_en @UZH_IPT doi.org/10.1038/s41592-026-0โฆ
Avraham Ashkenazi retweeted
PROTAC-Mediated Degradation of mHTT Aggregates Attenuates Neurotoxicity in Cellular and R6/2 Mouse Models of Huntingtonโs Disease | Journal of the American Chemical Society pubs.acs.org/doi/10.1021/jacโฆ
Avraham Ashkenazi retweeted
We are excited to announce that the Parkinsonโs Foundation and @ACSMNews, the worldโs largest sports medicine and exercise science organization, have announced updated recommendations to provide safe and effective guidance on exercise for people with Parkinsonโs disease.
The updated exercise recommendations were published following extensive review from subject matter experts, as well as members of the PD community who actively use the recommendations. Read more: Parkinson.org/about-us/news/โฆ
Avraham Ashkenazi retweeted
New online! Towards biomarker-based diagnosis of Parkinson disease dlvr.it/TQxnwd
Avraham Ashkenazi retweeted
Protective ApoE variants support neuronal function by effluxing oxidized phospholipids: Neuron cell.com/neuron/fulltext/S08โฆ
Avraham Ashkenazi retweeted
Articles in our latest collection focus on the roles of ATG9 and LC3 interacting regions, plus mechanisms of selective #autophagy involving Rab GTPases, #mitophagy, and #pexophagy. ๐ hubs.la/Q040Nfh60
Avraham Ashkenazi retweeted
Mecca et al. investigate the role of muscle stem cells in SMA and show that their depletion disrupts neuromuscular junctions and leads to motor neuron loss in the spinal cord. They conclude that muscle stem cells represent potential therapeutic targets. shorturl.at/vIwEU
Avraham Ashkenazi retweeted
Cell-type resolved protein atlas of brain lysosomes identifies SLC45A1-associated disease as a lysosomal disorder: Cell cell.com/cell/fulltext/S0092โฆ
Avraham Ashkenazi retweeted
๐ฃOur February issue is live! See below for #TIBS50 content, great Review articles, and more!
Find the issue ๐ cell.com/trends/biochemical-โฆ
Avraham Ashkenazi retweeted
A new advance in Huntingtonโs disease research
New findings from Tel Aviv University reveal cellular mechanisms that may influence disease progression, opening new directions for future therapies. Featured in Doctors Only.
Avraham Ashkenazi retweeted
Ishtayeh et al. identify the deubiquitinating enzyme UCHL3 as a potential therapeutic target in Huntingtonโs disease. Genetic and pharmacological inhibition of UCHL3 in mouse and patient-derived neurons reduced mutant huntingtin aggregation and toxicity. shorturl.at/UT0EN
Avraham Ashkenazi retweeted
Thrilled to share that my postdoc reserach about #TDP-43 local synthesis in #ALS is now published in @NatureNeuro!
Muscle-derived miR-126 regulates TDP-43 axonal local synthesis and NMJ integrity in ALS models | Nature Neuroscience
@LabPerlson
More details in thread.
Avraham Ashkenazi retweeted
Korsten et al employ live cell imaging and expansion microscopy to show that nuclear polyQ aggregates associated w/ #HuntingtonDisease induce nuclear envelope (NE) blebbing & cause NE ruptures. hubs.la/Q03JBmvx0
๐ Intermediate Filaments collection: hubs.la/Q03JBhNP0
Avraham Ashkenazi retweeted
We had the honor of welcoming our dear friends to our campus today for an inauguration that made history!
Read more about it: english.tau.ac.il/news/gray_โฆ
I was proud to join @TelAvivUni in honoring the Gray Foundationโs extraordinary giftโled by the formidable Mindy and Jon Grayโto the Faculty of Medical and Health Sciences. This remarkable act of generosity will power breakthrough research and train future medical professionals, bringing together Jews and Arabs, students and researchers from all walks of Israeli society, working and learning together โ saving lives and amplifying Israelโs role as a global beacon of medical innovation, compassion, and hope.
Avraham Ashkenazi retweeted
Excited to share our preprint: "๐๐ซ๐ ๐๐ง๐๐ฅ๐ฅ๐จ๐ฆ๐ข๐๐ฌ: ๐๐-๐๐ซ๐ข๐ฏ๐๐ง ๐๐๐๐ฉ ๐จ๐ซ๐ ๐๐ง๐๐ฅ๐ฅ๐๐ซ ๐ฉ๐ก๐๐ง๐จ๐ญ๐ฒ๐ฉ๐ข๐ง๐ ๐ซ๐๐ฏ๐๐๐ฅ๐ฌ ๐ง๐จ๐ฏ๐๐ฅ ๐๐๐ ๐ฆ๐๐๐ก๐๐ง๐ข๐ฌ๐ฆ๐ฌ ๐ข๐ง ๐ก๐ฎ๐ฆ๐๐ง ๐ง๐๐ฎ๐ซ๐จ๐ง๐ฌ"
๐๐๐ข๐ฌ๐ข๐จ๐ง-๐ญ๐ซ๐๐ง๐ฌ๐๐จ๐ซ๐ฆ๐ฌ-๐๐๐ฌ๐๐ ๐จ๐ซ๐ ๐๐ง๐๐ฅ๐ฅ๐๐ซ ๐ฉ๐ก๐๐ง๐จ๐ญ๐ฒ๐ฉ๐ข๐ง๐ ๐ฎ๐ง๐ฏ๐๐ข๐ฅ๐ฌ ๐ก๐ข๐๐๐๐ง ๐๐๐ ๐ฆ๐๐๐ก๐๐ง๐ข๐ฌ๐ฆ๐ฌ!
๐งต Thread on ๐๐๐๐ (๐๐ฆ๐ถ๐ณ๐ฐ๐ฏ๐ข๐ญ ๐๐ณ๐จ๐ข๐ฏ๐ฆ๐ญ๐ญ๐ฐ๐ฎ๐ช๐ค๐ด ๐๐ช๐ด๐ช๐ฐ๐ฏ ๐๐ต๐ญ๐ข๐ด)๐๏ธ our deep-learning model trained with ~3M images of human-derived neurons, and newly discovered insights into ALS disease. We used AI to map cellular dysfunction at un unprecedented resolution, comprehensively studying all sub-cellular organelles.
Preprint: "๐๐ซ๐ ๐๐ง๐๐ฅ๐ฅ๐จ๐ฆ๐ข๐๐ฌ: ๐๐-๐๐ซ๐ข๐ฏ๐๐ง ๐๐๐๐ฉ ๐จ๐ซ๐ ๐๐ง๐๐ฅ๐ฅ๐๐ซ ๐ฉ๐ก๐๐ง๐จ๐ญ๐ฒ๐ฉ๐ข๐ง๐ ๐ซ๐๐ฏ๐๐๐ฅ๐ฌ ๐ง๐จ๐ฏ๐๐ฅ ๐๐๐ ๐ฆ๐๐๐ก๐๐ง๐ข๐ฌ๐ฆ๐ฌ ๐ข๐ง ๐ก๐ฎ๐ฆ๐๐ง ๐ง๐๐ฎ๐ซ๐จ๐ง๐ฌ"
biorxiv.org/content/10.1101/โฆ
Check out our code and data: github.com/Sagykri/NOVA
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