@BursteinLab

Having fun with microbial genomic and machine learning @TelAvivUni

 Israel
burstein-lab.github.io/
Joined September 2022
  • Tweets230
  • Following360
  • Followers645
21Media
Burstein lab retweeted
Kenneth Loi
@kenjmloiOct 18
Viruses have parasites too. Our new preprint shows how phages use VIPR to silence parasitic satellites, and how the satellites fight back with its own decoy VIPR RNAs that redirect VIPR to DNA REP elements in the host genome!! biorxiv.org/content/10.64898…
4
33
4
137
9,078
Burstein lab retweeted
Tim Blower@BlowerLabOct 15
For all phage defence pholks - registration for the Symposium on the Immune Systems of Bacteria 2027 is now open! 20-22nd July, 2027, Churchill College, Cambridge, UK. See you there! sisb2027.info/

Symposium on the Immune System of Bacteria 2027

Visit the post for more.

sisb2027.info
14
26
799
Burstein lab retweeted
Dor Salomon@DrDorSalomonOct 15
Check out recent work: Artificial genetic augmentation of T6SS activity affects effector repertoire and host toxicity | Microbiology Spectrum journals.asm.org/doi/10.1128… In collaboration with @GerlicL

Artificial genetic augmentation of T6SS activity affects effector repertoire and host toxicity |...

The type VI secretion system (T6SS), a bacterial toxin-delivery apparatus, has recently been shown to mediate virulence in various marine Vibrio species. Each T6SS delivers a cocktail of toxins into...

journals.asm.org
1
5
20
685
Burstein lab retweeted
Sternberg Lab@SternbergLabOct 13
1/5 Telomerase has long been linked to chromosome maintenance in eukaryotes. Now, we show that telomerase-like activity is also present in bacteria, shedding new light on its ancient origins. Excited to share that our work on DRT10 is now out in @Nature! nature.com/articles/s41586-0…

Antiviral immunity via telomerase-like reverse transcription in bacteria

Nature - Antiviral immunity via telomerase-like reverse transcription in bacteria

nature.com
4
60
6
195
14,526
Burstein lab retweeted
Stanford University
@StanfordOct 5
The most important briefings of the day. Karl Deisseroth, professor of bioengineering and of psychiatry and behavioral sciences, shares the news of his Nobel Prize with his kids.
530
4,654
935
36,663
4,632,112
Burstein lab retweeted
Garyk Brixi
@garykbrixiSep 22
Genomes are full of dark matter of unknown functions. We present Minerva, a new method for discovery guided by genome language models. Minerva reveals the interactions hidden in non-coding DNA, pointing to hundreds of new putative RNAs and repetitive elements per bacterial genome. Minerva allows us to find and study elements invisible to traditional methods at orders of magnitude greater scale than before.
13
152
12
593
47,364
Burstein lab retweeted
David Li@_David_LiSep 22
Excited to share Minerva, our approach using genome language models for biological discovery! Using Minerva, we find that UG27 reverse transcriptase systems encode variable arrays of diverse ncRNAs with a shared structure, each templating a short DNA hairpin. With @garykbrixi.
20
114
28
479
124,972
Burstein lab retweeted
Martin Pacesa@MartinPacesaSep 21
ʙɪɴᴅᴄʀᴀꜰᴛ2 is out, and we're not waiting for the paper. The full code drops today, free for academic and industry use. We're releasing it early so you can start designing right now, and bring its full power to the current Adaptyv competition. github.com/PacesaLab/BindCra…
32
332
24
1,490
163,830
Burstein lab retweeted
Kenneth Loi
@kenjmloiSep 17
VIPR is now out in @ScienceMagazine! What started with a mysterious RNA led us to an unexpected way of recognizing DNA, as well as some clues to CRISPR’s origins. So happy to share these two papers with an incredible team. Links below; original discovery thread here ↓
Kenneth Loi
@kenjmloiApr 27
Excited to share our discovery of a new programmable RNA-guided DNA-targeting system hiding inside bacteriophages that predates CRISPR. We call it VIPR (Viral Interference Programmable Repeat), and it uses an entirely new logic to find its targets. Thread + link below.
1
32
1
123
11,018
Burstein lab retweeted
Artem Isaev@Artem_Isaev_Sep 11
Chromatin structure controls defense island expression! Why do some systems defend on plasmids but fail natively? H-NS is key. Removing it boosts defense and beats anti-defense proteins but raises toxicity. Lab strains still hide novel immunity modules! biorxiv.org/content/10.64898…

H-NS silences antiviral immunity through 3D chromatin compaction

Bacterial antiviral immunity systems can be toxic to their hosts and must be tightly regulated. Immunity genes are often encoded by AT-rich mobile genetic elements subjected to silencing by nucleoid...

biorxiv.org
1
21
41
3,260
Burstein lab retweeted
Sergey Ovchinnikov@sokryptonSep 17
Also a highly experimental port of these models into WebGPU, allowing direct prediction on your 💻: localfold.org WARNING: will drain battery🪫, overheat 🔥💻 & eat your data plan 📱 Started by Martin Steinegger as AF2 port to WebGPU martin-steinegger.github.io/… (3/3)
3
18
3
174
41,658
Burstein lab retweeted
Sergey Ovchinnikov@sokryptonSep 17
ColabFold 1.6.3 is out! 2.5x faster, pip-installable, ipSAE+pDockQ2 scores. Thanks Choonghwan Lee, Marielle Russo, Gyuri Kim, Martin Steinegger, Milot Mirdita 🐍 pip install colabfold[alphafold] (1/3)
1
112
4
508
21,904
Published now in @Nature - "Long-read sequencing reveals pre-meiotic gene conversion in sperm". We show an unexpected source of new genetic variation in human sperm, occuring earlier in development than previously thought. Check it out here: nature.com/articles/s41586-0… Thread: 1/

Long-read sequencing reveals pre-meiotic gene conversion in sperm

Nature - Single-molecule long-read sequencing of human sperm reveals variation in recombination across donors and that a substantial fraction of non-crossover gene conversions arises before...

nature.com
2
27
4
99
9,005
The leading region of many plasmids is adapted for translational efficiency doi.org/10.1093/nar/gkag810

The leading region of many plasmids is adapted for translational efficiency

Abstract. To successfully transfer, conjugative plasmids must overcome a recipient cell’s defence mechanisms. The leading region of many plasmids—the first

academic.oup.com
4
6
245
Burstein lab retweeted
Avigdor Eldar@AvigdorEldarAug 20
Toxin-Antitoxin systems are thought to induce death or dormancy under some stress conditions. Focusing on the well studied MazEF system, we now show that this is not always the case. biorxiv.org/content/10.64898…

Highly specific mRNA cleavage by the MazF endoribonuclease orchestrates stationary transcriptome...

Bacterial toxin-antitoxin (TA) systems are classically viewed as stress-activated toxic switches. Specifically, ribonucleolytic toxins are thought to indiscriminately cleave RNA to halt cellular...

biorxiv.org
1
4
19
885
Burstein lab retweeted
Frederik Schulz
@frederikschuAug 8
Riboseek encodes RNA and DNA sequences as overlapping di-mers and detects homologs more sensitively than BLASTN and nhmmer. It produces alignments 250-fold faster than nhmmer and 376-fold faster than rMSA. doi.org/10.64898/2026.07.31.…
1
8
41
3,481
Burstein lab retweeted
Sternberg Lab@SternbergLabAug 3
Out now! In collaboration with Hiroshi Nishimasu's lab, we uncover how a dual reverse transcriptase immune system builds double-stranded DNA from both RNA and protein templates. sciencedirect.com/science/ar… Previous thread for the preprint: xitter.cf/SternbergLab/status/20…
Sternberg Lab@SternbergLabMay 12
1/9 New preprint from the Sternberg Lab in collaboration with the Nishimasu Lab! We uncover how the DRT3 antiphage immune system pairs two reverse transcriptases, one RNA-templated and one protein-templated, to build a double-stranded DNA effector. doi.org/10.64898/2026.05.04.…
1
24
2
118
15,126
קטע מדהים מיומן ברלין של חסידת אומות העולם רות אנדריאס-פרידריך. בכלל המלצת מעקב חמה על מני אדלר שמביא כל יום קטעים נפלאים מספרי הסטוריה והופך את הפיד למרתק
Meni Adler@meniadlerJul 23
יום ו, 24 בפברואר 1939 כולם מדברים בברלין על 'ליפטים'. הכוונה איננה למעליות הנוסעים בבתי מלון מפוארים, אלא לארגזי העץ הגדולים שבהם אורזים את מטלטליהם המהגרים ששיחק להם מזלם לעזוב את גרמניה. מזה ששה שבועות מהווה 'הליפט' את הנושא המרכזי לכל שיחה בחוג מכרינו.
1
2
300
1/4 Every good defence needs a backup 🛡️⚔️ Out now in @NatureRevMicro our Comment on "𝗶𝗺𝗺𝘂𝗻𝗲 𝘀𝗮𝗳𝗲𝗴𝘂𝗮𝗿𝗱𝗶𝗻𝗴"! 🎉 🔗 nature.com/articles/s41579-0…

Immune safeguarding as a conserved principle of antiviral defence

Nature Reviews Microbiology - All organisms defend against viral infections through active immunity mechanisms that clear the virus or population-level mechanisms that cause regulated cell death....

nature.com
1
10
1
19
1,892
1/10 🚨Preprint! One RING to rule them all (phages)👑💍⚔️ Bacteria build giant DNA-scaffolded RNase rings (larger than the ribosome!) to shut down viral infection🧬🧵👇 🔗biorxiv.org/content/10.64898…
5
62
2
198
12,730
Load more