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Joined June 2018
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Center for Resuscitation Science at BIDMC retweeted
CRRT vs intermittent renal replacement trial stopped early for concern of signal of worse mortality in intermittent group. You might need to read the conclusion a couple times though "intermittent hemodialysis was not noninferior to CRRT"
Presented at #LIVES2026:
An open-label, randomized, noninferiority trial showed that intermittent hemodialysis was not noninferior to continuous renal-replacement therapy in critically ill adults with acute kidney injury. Full ICRAKI trial results: nej.md/472QMel
Editorial: Continuous or Intermittent Renal-Replacement Therapy — What is the Question? nej.md/4egLaB1
ALT A graph from the Original Article "Intermittent or Continuous Renal-Replacement Therapy in Acute Kidney Injury." The trial name, ICRAKI, is in parentheses after the title. The graph shows the cumulative probability of death from randomization through day 90, as estimated with the Kaplan–Meier method. The trial results are being presented at the European Society of Intensive Care Medicine. The logo of the New England Journal of Medicine is at the bottom.
Center for Resuscitation Science at BIDMC retweeted
Reviewed three recent randomized trials for long Covid.
Two are positive -- exciting news! -- and one is difficult to talk about. Free-to-read link in replies. @NEJM @NEJMClinician
Center for Resuscitation Science at BIDMC retweeted
Thinking of you guys (Chris Slattery and Rob McLaughlin) today and all who were killed on 9/11. Never Forget 🇺🇸 🇺🇸
Center for Resuscitation Science at BIDMC retweeted
Important case - I caught a couple of these over the years labeled as sepsis or actively septic but then had some exposure - always makes me wonder if there are others that are missed.
Center for Resuscitation Science at BIDMC retweeted
Long COVID RCT results (n=126) as presented @ISLCPAIS in abstract form: PSRT had statistically significant & clinically meaningful improvement of primary endpt (somatic symptoms, SSS-8) & secondary endpts of fatigue, physical function, cognitive function, pain, & shortness of breath compared to two different control groups (usual care & mindfulness-based stress reduction [MBSR]). 1/2
Center for Resuscitation Science at BIDMC retweeted
Just arrived in Amsterdam and looking forward to sharing the results of our randomized trial (n=126) of PSRT for Long COVID at the @ISLCPAIS conference!
Center for Resuscitation Science at BIDMC retweeted
Applications are open for the 2027-28 Zimetbaum Fellowship! Pls share with your network. Open to med students & residents interested in building a foundation in outcomes & policy research @SmithBIDMC. Apply by Oct 1: bit.ly/4m3qYnY
Center for Resuscitation Science at BIDMC retweeted
Odd: High-dose flu vs. flu vax RCT in NEJM where primary endpoint NOT analyzed (stated reason of event rate too low) yet the conclusions are "appeared to be fewer" hospitalizations. I've never seen this in a major clinical trial before - am I missing something? Any precedence?
In adults 65 to 79 years of age, there appeared to be fewer hospitalizations for influenza or pneumonia with high-dose influenza vaccine than with the standard dose, with a similar incidence of serious adverse events. Full GALFLU trial results and Research Summary: nej.md/46712T2
ALT The New England Journal of Medicine High-Dose Influenza Vaccine to Reduce Hospitalizations A Research Summary based on Pardo-Seco J et al. | 10.1056/NEJMoa2509834 | Published on August 30, 2025 Visual representations of the patients in the trial and the treatments they were assigned. Read the full Research Summary at NEJM.org.
Center for Resuscitation Science at BIDMC retweeted
Original Article: A Pragmatic Trial of Glucocorticoids for Community-Acquired Pneumonia (SONIA trial) nej.md/47glh02
Editorial: Glucocorticoids for Pneumonia in Africa — Old Therapy, New Context nej.md/4qgjdxH
#Pulmonology #CriticalCare
ALT A graph of the cumulative risk of death from any cause.
Center for Resuscitation Science at BIDMC retweeted
Original Article: Ketamine or Etomidate for Tracheal Intubation of Critically Ill Adults nej.md/44EOlxB
@CritCareReviews
ALT A figure showing in-hospital death, according to trial group.
Hi All, Let's give Ari Moskowitz @Moskowcrit a follow as his account was hacked and this is new account @Moskowcrit Crit Care at Monte in NY and longtime CRS member and collaborator! @NickJohnsonMD
For my EM and critical care followers, Ari Moskowitz's @Moskowcrit X account was hacked and he had to get a new account going from 1K+ followers to 20s. His new account is: @Moskowcrit
Center for Resuscitation Science at BIDMC retweeted
CONTROVERSIAL TAKE: In 2005, ACLS guidelines made a dramatic change to solve a specific problem. But, the change was made without much data and should this be reconsidered 20 years later? 1/
Center for Resuscitation Science at BIDMC retweeted
KETAMINE VS. ETOMIDATE RCT (n=2,365). NO difference in 28-day mortality..But, ketamine worse secondary endpt of "cardiovascular collapse" 22% v. 17% though seemingly driven by hypotension as opposed to cardiac arrest (combined endpoint of SBP<65, new/incr vasopressor, CA).
Presented at CCR Down Under 2025:
In a randomized trial involving critically ill patients undergoing intubation in EDs or ICUs, the use of ketamine for the induction of anesthesia did not lead to significantly lower in-hospital mortality than etomidate. Full trial results: nej.md/44EOlxB
@CritCareReviews
ALT CCR Down Under 2025 Original Article | Dec. 9, 2025 | NEJM.org Ketamine or Etomidate for Tracheal Intubation of Critically Ill Adults Figure 1. In-Hospital Death, According to Trial Group. The NEJM identity sits at the bottom.
Great job @MuhammadMu10165 on presenting his work on CoQ10 and Lipoid acid in cardiac arrest! Increasea oxygen consumption in-vitro but can we translate this to in-vivo and then someday to outcomes? More work to come!
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Center for Resuscitation Science at BIDMC retweeted
⭐ We are delighted to share that the International Liaison Committee on Resuscitation (ILCOR) general assembly has appointed Katherine M. Berg, MD as Co-Chair.
Read the full news here 👉 bit.ly/48TOL6y
#ILCOR #resuscitation #ResuscitationScience
Center for Resuscitation Science at BIDMC retweeted
NEW arterial line study which is portrayed as "arterial line" versus 'no arterial line" comparison for those who would typically get an a-line. But, this might NOT be the case and may not really be reflective of the study design! 🧵🧵
nejm.org/doi/full/10.1056/NE…
Center for Resuscitation Science at BIDMC retweeted
JAMA - large RCT of Bicarbonate infusion versus no infusion for metabolic acidosis in setting of acute kidney injury - no difference in 90-day mortality. Plan to look in more detail but bunch of interesting studies from ESICM this year.
For #criticallyill patients who had both severe metabolic acidemia and moderate to severe acute kidney injury, sodium bicarbonate therapy did not significantly decrease day 90 all-cause mortality.
#LIVES2025 @ESICM
ja.ma/4nsi8jE
Center for Resuscitation Science at BIDMC retweeted
SOFA 2.0 just published in JAMA. Will take a deeper dive but interesting to see this out and need consider implications for our currently enrolling RCTs (ie., steroids in pancreatitis).
jamanetwork.com/journals/jam…
Center for Resuscitation Science at BIDMC retweeted
I'll be doing the "con" of a debate at the AHA ReSS meeting in New Orleans on the broad topic of the new 2025 BLS/ACLS guidelines (link below). I have an idea of where I will go with this but want to hear yours - what controversies would you discuss? ahajournals.org/toc/circ/152…
