@Cannabatopia

Assistant Prof, Biochem @UMmedschool / membrane protein structure & dynamics; cryoEM fixated

 Baltimore, MD
Joined February 2016
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Excited to share our latest work! My lab in collaboration with Dr. Jacobson's lab has decoded how the P2Y14 receptor binds uracil and glucose. This purinergic GPCR continues to reveal its secrets. ❄️🔬nature.com/articles/s42003-0…

UDP-glucose and MRS2905 agonist-bound states of the purinergic P2Y14 receptor

Communications Biology - The authors cracked P2Y14’s “sweet tooth”: structures bound to UDP-glucose and MRS2905 decode hexose and uracil nucleotide selectivity. A bipartite...

nature.com
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In collaboration with Dr. Farrens and Yao. Ever wonder how you see green, even when the sun be blastin? We’ve been digging deep into the greenest receptor around. 👀 Excited to share our latest publication: pnas.org/doi/10.1073/pnas.25…

Structure of human green cone opsin yields insights into mechanisms underlying the rapid decay of...

Cone opsins enable daylight vision and color discrimination. Like their dim-light cousin rhodopsin (Rho) found in rod cells, they use a covalently ...

pnas.org
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I am excited to share our latest work in @Neuron exploring the pharmacology of psychedelics. I am deeply grateful to my PI, Prof. Bryan Roth, @zenbrainest, for his exceptional guidance, and to all my co-authors for their valuable collaborations.
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It's finally out! Our "somewhat" thorough study on psychedelic polypharmacology. Congrats to @jainmk6 @zenbrainest and everyone else involved! sciencedirect.com/science/ar… #psychedelics
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Happy to share that this work on the structural biology of #psychedelics is finally out! Big shout out to all involved, especially @zenbrainest for all of the support! The structural diversity of psychedelic drug actions revealed | Nature Communications nature.com/articles/s41467-0…

The structural diversity of psychedelic drug actions revealed

Nature Communications - The authors present 7 cryo-EM structures of hallucinogenic and non-hallucinogenic compounds across multiple chemotypes bound to the 5-HT2A receptor, shedding light onto...

nature.com
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Jon Fay retweeted
Tao@TaoChelab14 Mar 2025
Glad to share a great teamwork with @sushmajumdarlab @sevakat1, Jay McLaughlin lab, and @AmynahPradhan @Cannabatopia. This bitopic approach pioneered by Drs. Majumdar and Katritch works pretty well in GPCRs. Thanks to the support from @NIDAnews and WashU nature.com/articles/s41467-0…
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Yuuge paper on #psychedelics The structural diversity of psychedelic drug actions revealed nature.com/articles/s41467-0…
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Happy to share a pre-print of some recent work. This is our first time using bioRxiv. I suspect we will be using it more moving forward.
biorxiv_biochem@biorxiv_biochem26 Jul 2024
Human P2X4 receptor gating is modulated by a stable cytoplasmic cap and a unique allosteric pocket biorxiv.org/cgi/content/shor… #biorxiv_biochem
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Lessons from a Toad Psychedelic about the Role of different Serotonin Receptors in Psychedelic Physiology: nature.com/articles/s41586-0… Congrats to Audrey and @LankriDavidIL in this collab with @SamesLab and @ScottRusso published in @Nature
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Why do phosphate-containing medications cause itch? MRGPRX4! Latest @RothLabUNC @Cannabatopia and Dong Lab (HHMI/Hopkins) collaboration: doi.org/10.1126/scitranslmed…

MRGPRX4 mediates phospho-drug–associated pruritus in a humanized mouse model

Phosphate modification of medications triggers pruritus through the sensory neuron receptor MRGPRX4.

science.org
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Excited to have published our collaborative research on the secretory trafficking of the SARS-CoV-2 spike! #SARSCoV2 #spike #NMR @NIGMS @NatureComms @UMmedschool @UMBaltimore @UMD_IBBR @UMDCBMG @ChemBiochemUMD @LoyolaMiim @debajtdey @pierce_lab nature.com/articles/s41467-0… – at Maryland, USA
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exciting!
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This was a sad day in the lab, however these columns can be fixed! Cytiva will tell you otherwise but here is how you do it.
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Replying to @IsraelF96135088
Remember that you can't install SerialEM or Leginon on a Thundra because the TEM scripting tools are locked. That's a no go for me personally.
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Dinner with the two heroes of our recent @NIGMS R01 grant: Debajit (@debajtdey) and Suruchi. – at Frederick, MD
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Expanding the mol bio station…
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Happy to share the final version of this! We summarize recent structural work that can help understand the intricate pharmacology of drugs of abuse. Many thanks to everyone involved @NeuroStructure @WackerLab @john_mccorvy jbc.org/article/S0021-9258(2…

Molecular insights into GPCR mechanisms for drugs of abuse

Substance abuse is on the rise, and while many people may use illicit drugs mainly due to their rewarding effects, their societal impact can range from severe, as is the case for opioids, to promis...

jbc.org
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After discussion with Richard Henderson at #IMC20, I updated the format of X-ray/cryo-EM ratio. With this format, we can plot even in the middle of year.
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Foundations of #CryoEM: This page (cryoem101.org/chapter-3/) on cryoem101.org gives beginners an idea of what to look for in their micrographs. They also raise a good point–that sometimes the best way to eval quality is to collect and process a small dataset.
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A special labs get together
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