Obesogenic High-Fat Diet and MYC Cooperate to Promote Lactate Accumulation and Tumor Microenvironment Remodeling in Prostate Cancer out on @CR_AACR aacrjournals.org/cancerres/a… Study explores how systemic metabolism, particularly through a high-fat diet (HFD) rich in saturated fats, accelerates c-MYC-driven #ProstateCancer progression by rewiring tumor metabolism. In a mouse model🐭the combination of c-MYC🧬 activation and an obesogenic HFD led to increased glycolysis and lactate accumulation in tumors, which promoted immune changes, including higher infiltration of tumor-associated macrophages and regulatory T cells. These alterations contributed to tumor growth, therapy resistance, and angiogenesis, which were reduced by lactate dehydrogenase inhibition. Clinical data🥼 revealed similar tumor metabolic shifts in prostate cancer patients with high saturated fat intake, suggesting lactate's potential as a biomarker and target for dietary and therapeutic interventions in advanced prostate cancer. @RIMUHC1 @BoufNadia @Carole_Luthold @eddieimada of @WCMCPathology @Davicioni @DrSpratticus Lisa M. Butler of @UniofAdelaide Massimo Loda of @WeillCornell @DavidP_Labbe @ZadraGiorgia