Dignite Fabrice NGANGO (@DigniteN) profile picture

Dignite Fabrice NGANGO

@DigniteN
Joined January 2018
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Dignite Fabrice NGANGO retweeted
Communications Biology (@CommsBio) profile picture
Communications Biology@CommsBioMay 14
Reduced catalytic activity of KPC β-lactamase can increase ceftazidime resistance: Communications Biology, Published online: 07 April 2026; doi:10.1038/s42003-026-09969-1KPC β-lactamase variants with mutations D179Y, T243M, and H274Y evolve increased… dlvr.it/TSXbBp
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Dignite Fabrice NGANGO retweeted
Tim Palzkill Lab (@PalzkillLabBCM) profile picture
Tim Palzkill Lab@PalzkillLabBCMFeb 4
We rarely question buffers — maybe we should. In a recent study from our lab, we show that phosphate inhibits KPC-2, underestimating enzyme activity and inhibitor potency. Great work @DigniteN 👏 Go check it out 👇 journals.asm.org/doi/10.1128… @ASMicrobiology
Phosphate sensitivity of KPC-2: a hidden variable in β-lactamase kinetics | Antimicrobial Agents...

Phosphate sensitivity of KPC-2: a hidden variable in β-lactamase kinetics | Antimicrobial Agents...

Antibiotic resistance remains one of the most pressing global public health challenges, contributing to approximately 10 million deaths annually (1). A major mechanism of resistance is the bacterial...

journals.asm.org
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