Professor/Chair of the Dept of Biochemistry and Molecular Pharmacology at BCM. Using structural and molecular biology to answer the big questions since 1991.
Houston, TX
Joined January 2022
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We rarely question buffers — maybe we should.
In a recent study from our lab, we show that phosphate inhibits KPC-2, underestimating enzyme activity and inhibitor potency.
Great work @DigniteN 👏 Go check it out 👇
journals.asm.org/doi/10.1128…
@ASMicrobiology
Long overdue shoutout to
@paoriverat, a second-year graduate student in Dr. Palzkill Lab, for earning a competitive Molecular Basis of Infectious Diseases (MBID) training grant.
Congratulations to Michael A. Lopez, a second-year graduate student in the Palzkill Lab, for being awarded the Training Interdisciplinary Pharmacology Scientists Program (TIPS) predoctoral fellowship! Your hard work and dedication are truly commendable.
🎓🌟 Big shout out to Dr. @postdoctorallie , Dr. Lynn Su, and Dr. Jane Park, former lab graduates, who rocked the stage at the recent hooding ceremony, donning their well-deserved hooding hats! 🎩👏 Keep shining bright, champs! 💫 #Graduation #BCM
Congratulations to Jiayi Fan for winning first place for Poster Presentations in the BCM GSBS Symposium, great work!
Check out our latest publication in PNAS about using large-scale deep mutational scanning to study epistatic interactions in an enzyme active site.
Great work done by @itsDrAllie.
doi.org/10.1073/pnas.2313513…
Tim Palzkill Lab retweeted
50,000+ enzyme variants tested. A new catalytic mechanism. A highly interconnected, substrate-dependent network of amino acid interactions discovered. Blood, sweat, tears (mine). This story has it all, folks: pnas.org/doi/10.1073/pnas.23…
@PNASNews @PalzkillLabBCM
A happy gathering of our lab group at the Biochemistry and Molecular Pharmacology Holiday Luncheon. 🎄
Tim Palzkill Lab retweeted
Some work by my labmates @PalzkillLabBCM that I helped with during my PhD went live over the holidays! We used DNA-encoded libraries to find highly potent inhibitors of two prominent carbapenemases, NDM-1 and OXA-48.
pubs.acs.org/doi/abs/10.1021…
Check out our latest publication in the Journal of Medicinal Chemistry about the use of DNA encoded libraries to discover novel beta-lactamase inhibitors.
doi.org/10.1021/acs.jmedchem…
@JiayiFan217 @tgpalzkill
Check out our recently published work on the proposed mechanism of how KPC-44 acquires ceftazidime-avibactam resistance:
doi.org/10.1016/j.jbc.2023.1…
We have one more defense to finish out the month! Allie Judge will defend her dissertation Thursday at noon.
On another (totally unrelated…) note, the BCM graduate school application opens September 1st for those interested in continuing the legacy of these three newly-minted PhDs!
bcm.edu/education/graduate-s…
We have a second dissertation this week! Lynn Su will defend her dissertation tomorrow at 2 PM, and you can listen in person or via Zoom.
Tim Palzkill Lab retweeted
So happy to share this story and that I was able to play a small part in it! We discovered and validated highly potent small molecule inhibitors of the SARS-CoV-2 main protease, including variants that show resistance to current antiviral treatments.
A new type of SARS-CoV-2 Mpro inhibitor is discovered by DNA-encoded chemical library screening, reported by @bcmhouston & @DamianYoung29 & @Srini_Chamakuri & @PalzkillLabBCM nature.com/articles/s42004-0…
Tim Palzkill Lab retweeted
A new type of SARS-CoV-2 Mpro inhibitor is discovered by DNA-encoded chemical library screening, reported by @bcmhouston & @DamianYoung29 & @Srini_Chamakuri & @PalzkillLabBCM nature.com/articles/s42004-0…
Dr. Cristina Materon recently published a review on polymyxin resistance mediated by MCR-1 sciencedirect.com/science/ar…
Check out our recently published work from graduate student Lynn Su on Norovirus epitopes for potential vaccine targets: nature.com/articles/s41541-0…