@DikicLab

Research group of @iDikic2 at @IBC2_GU. ubiquitination, autophagy, host-pathogen interactions

 Frankfurt, Germany
biochem2.com/research-group/molecular-signaling
Joined August 2020
  • Tweets141
  • Following79
  • Followers1.2K
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🎙️Honored to enjoy insightful presentations on “RNA-based therapeutics” & “New targets & therapeutic approaches” on day 2 of the 1st Symposium on Advances in Therapeutic Approaches.🙏Thanks to all speakers & participants for their valuable contributions. @BMBF_Bund @HMWK_Hessen
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SFB 1177@sfb117726 Nov 2024
Excited to announce the keynote speakers at #FCQC2025! Aaron Ciechanover from @TechnionLive and @dixitvishva from @genentech Stay tuned for more updates and don't forget to register!  fcqc.de/ #autophagy #ubiquitin #TPD #UPS #signaling
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How changes in kinetics of #splicing can lead to proteotoxic cell death & what is the role of #ubiquitination and ER-phagy in this process? Congrats to Cristian & all collaborators for this fascinating discovery 👏 More info: xitter.cf/IBC2_GU/status/1857149… science.org/doi/10.1126/scie…
Cristian Prieto-Garcia@CristianPG_mlg14 Nov 2024
It is finally out! My first @ScienceMagazine paper is online and it does not seem real😃. I am Incredibly happy! Really thanks to all my coauthors and special mention to my incredible supervisor @iDikic2 for all the support and trust ! 🫶. Science science.org/doi/10.1126/scie…

Pathogenic proteotoxicity of cryptic splicing is alleviated by ubiquitination and ER-phagy

RNA splicing enables the functional adaptation of cells to changing contexts. Impaired splicing has been associated with diseases, including retinitis pigmentosa, but the underlying molecular...

science.org
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I am very happy to have had the opportunity to present our latest results on targeting #legionella with #protacs. Especially in a session with such renowned scientists. Thanks to Antje Flieger and her team at @rki_de for organising this meeting.
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Really happy to take part of this amazing manuscript from @crypt_tales and @DiefenbacherL published in @oncogenejournal . USP10 promotes colorectal cancer and stemness. #ubiquitin #cancerResearch 🫶👏🏻
Michaela Reissland@crypt_tales4 Nov 2024
🥳I am beyond to finally share the story of my PhD out now: USP10 drives cancer stemness and enables super-competitor signalling in colorectal cancer nature.com/articles/s41388-0… Lets have a little look what we found: 🧵1/11

USP10 drives cancer stemness and enables super-competitor signalling in colorectal cancer

Oncogene - USP10 drives cancer stemness and enables super-competitor signalling in colorectal cancer

nature.com
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I’m thrilled to share that my latest research paper has been published in PNAS! 📄 pnas.org/doi/10.1073/pnas.24… A big thank you to all the co-authors 🙏 @RamBhaskara4 @KateLohachova @iDikic2 @HummerLab. Thanks to @IBC2_GU @BMLS @EnableFrankfurt @sfb1177 @dfg_public
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Really happy to contribute with mouse liver cancer models and human cancer data analyses to this amazing Cell paper from @iDikic2 and Herhaus lab. Huge congrats to Lina, Uxia, Ivan and other authors from @jwadeharperlab , @ManciasLab, @DikicLab, etc.👏🏻 sciencedirect.com/science/ar…
Cell@CellCellPress30 Oct 2024
Now online! IRGQ-mediated autophagy in MHC class I quality control promotes tumor immune evasion dlvr.it/TFvLRM

IRGQ-mediated autophagy in MHC class I quality control promotes tumor immune evasion

IRGQ acts in the quality control of MHC class I molecules through autophagy, mediating tumor immune evasion.

cell.com
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Dikic lab retweeted
Cell@CellCellPress30 Oct 2024
Now online! IRGQ-mediated autophagy in MHC class I quality control promotes tumor immune evasion dlvr.it/TFvLRM

IRGQ-mediated autophagy in MHC class I quality control promotes tumor immune evasion

IRGQ acts in the quality control of MHC class I molecules through autophagy, mediating tumor immune evasion.

cell.com
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An amazing day 1! Log on tomorrow !!
Women in Autophagy@WAutophagy28 Oct 2024
And we will be back tomorrow with much more beautiful science in #WIA2024meeting don't miss it!!
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Still open to registration...don't miss the event of the year!! ⬇️⬇️⬇️
Women in Autophagy@WAutophagy21 Oct 2024
#ProgramAlert have you seen our updated program?? This annual meeting will be fantastic!! Are you going to miss it? Register here: forms.office.com/r/vXS654upE… you @BiochemSoc and @Co_Biologists for your support! @patricia_boya @AIM_autophagy @autophagyuk @SEFAGIA_ @Autophagy_India
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Fantastic time in @CIPFciencia and #Valencia. Many thx to @RosaFarras for hospitality, great discussions, memorable dinner and perfect weather 😊😀 #Ubiquitination #Autophagy
CIPF@CIPFciencia17 Oct 2024
We enjoyed today at CIPF the #FBRLectureSeries conference “Ubiquitin and Autophagy networks in regulation of health and disease” conducted by Prof. Ivan Dikic from @goetheuni Frankfurt about molecular mechanisms of the ubiquitin-proteasome system (UPS) and autophagy. @iDikic2
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Webinar:  Autophagy's hidden drivers: Exploring the role of post-translational modifications | Science | AAAS science.org/content/webinar/…

Autophagy's hidden drivers: Exploring the role of post-translational modifications

science.org
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#Degradation resistant #tumors - grant funded by German-Israeli foundation for teams from @goetheuni, @HelmholtzMunich & @TechnionLive. We rented a cottage in the beautiful Swiss Alps for our retreat. Discussing science, walks, peaceful nights with stars, fondue and fun... 😊
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#ProgramAlert have you seen our updated program?? This annual meeting will be fantastic!! Are you going to miss it? Register here: forms.office.com/r/vXS654upE… Thank you @BiochemSoc for your support! @patricia_boya @AMCuervoLab @AIM_autophagy @autophagyuk @SEFAGIA_ @Autophagy_India
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Dikic lab retweeted
Ivan Đikić@iDikic27 Oct 2024
Starting #Frankfurt Competence Center for Emerging #Therapeutics (#FCET) as part of Go4Tec at @goetheuni to serve scientists. Huge thx to many in GU particularly from @IBC2_GU who helped turning this vision into reality... proud 🫶👍☺️ More info: linkedin.com/feed/update/urn…
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Emerging roles of #ubiquitin in regulating dynamic changes of membrane protein complexes have diverse biological functions including #organelle structures, selective #autophagy and others...Thx Anne @acjacomin for your fantastic contribution😊😀
Cell Chemical Biology@CellChemBiol20 Sep 2024
#OpenAccess #Featured #Review Membrane remodeling via ubiquitin-mediated pathways by @acjacomin and @iDikic2 at @goetheuni @IBC2_GU @MPIBP dlvr.it/TDTQ5L
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Feeding #cancer to death - a spotlight on interesting findings by Ciechanover's lab describing metabolic regulation of proteasome sequestration to the nucleus that promotes tumor #celldeath - reported in @cddpress 😀 nature.com/articles/s41418-0… nature.com/articles/s41418-0…
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Check our new: MEET OUR AUTOPHAGY EXPERTS womeninautophagy.com
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S🅰V🅴 the DATE: October 28th (10:00- 15:00 EST), October 29th (18:00-23:00 EST) 𝗗𝗿. 𝗬𝗼𝘀𝗵𝗶𝗻𝗼𝗿𝗶 𝗢𝗵𝘀𝘂𝗺𝗶 and 𝗗𝗿. 𝗣𝗮𝘁𝗿𝗶𝗰𝗶𝗮 𝗕𝗼𝘆𝗮! Register here: forms.office.com/r/vXS654upE… 📝Submit your abstract Deadline Sep, 13, 2024 forms.office.com/r/3LE3cL1Hc…
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First up is #Ubiq24 and we’re starting with none other than @iDikic2 presenting on UBIQUITIN & AUTOPHAGY NETWORKS IN REGULATION OF ER REMODELLING
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