Surveyors of the protein degradation landscape in the ER
Oxford, UK
Joined October 2013
- Tweets221
- Following180
- Followers596
- Likes569
Christianson Lab retweeted
It was a pleasure to be @UniofOxford for the DPhil viva of (twitterless) Ava Van Ess @VdangioE3lab. Many thanks to Ava and @ERADLab for the fun discussion and excellent hospitality #dressdownmondays
Christianson Lab retweeted
A subset of polytopic membrane proteins, such as subunits of the GABAA receptor, remains incompletely inserted when translation is terminated. We describe an essential post-translational step that completes insertion of such proteins. nature.com/articles/s41594-0…
Christianson Lab retweeted
Delighted that our paper on degraders and stabilisers of squalene synthase in @ChemicalScience has been highlighted as #chemscipicks! Fantastic work by @HoockJoseph with great support by Cecilia, Mesut, @ERADLab and @Laura_dta!
This week's #ChemSciPicks brings to you a strategy for squalene synthase degradation by @HoockJoseph with @laraialab from @ChemistryDtu.
Read it for free at doi.org/10.1039/D3SC04064J
Christianson Lab retweeted
New work from our group out today! Loss of Grp170 results in catastrophic disruption of endoplasmic reticulum functions biorxiv.org/content/10.1101/…
Christianson Lab retweeted
Protein degradation from the ER (not ERAD, but ERLAD!)
ER‐to‐lysosome‐associated degradation in a nutshell: mammalian, yeast, and plant ER‐phagy as induced by misfolded proteins - Rudinskiy - 2023 - FEBS Letters - Wiley Online Library febs.onlinelibrary.wiley.com…
Christianson Lab retweeted
PhD opening in my lab at the University of Dundee open to UK-based students. Details in link below - reach out if you have any questions!
findaphd.com/phds/project/ea…
Christianson Lab retweeted
Thanks to an amazing group of students for organizing such a fun and diverse symposium with @ERADLab @Amelie_HJ @anne_grapin @jwadeharperlab @LacefieldLab (almost pictured), Brenda (no twitter) et al.!
We are getting excited….a few more hours to go…tomorrow, Wed 10 May, at 09:00 the @IMPRS_LM student symposium, „Building Blocks of Life“, is starting. We are looking forward to welcoming a superb line-up of speakers!
Christianson Lab retweeted
Here is our teamwork with Keiji, Teru and Ken Anderson @DanaFarber, Ralph Mazitschek group @mazit, the Myeloma teams at BMS and Oxford University @DrSarahGooding @kritika_singh24 @AdamCribbs @ERADLab @UniofOxford @BotnarOxford
doi.org/10.1038/s41408-023-0…
nature.com/articles/s41408-0…
Christianson Lab retweeted
Postdoctoral and technician positions are opened in Carmine Settembre's Lab @Carmine21678!
Positions are funded by a ERC Grant (2023-2028)
More info at:
tigem.it/newsroom/career-opp…
Christianson Lab retweeted
Cellular compartmentation requires stringent sorting of thousands of proteins to their correct destination. Our new pre-print bit.ly/3FjWg7v describes a novel source of specificity that controls sorting of aggregation prone membrane proteins to the correct organelle. 1/8
Christianson Lab retweeted
In our final paper for 2022 Pei-Ling developed an elegant screening approach to close a major gap in our understanding of protein quality control: the identification of the machinery responsible for protein turnover in the mammalian nuclear envelope
doi.org/10.1016/j.celrep.202…
Christianson Lab retweeted
It’s intuitive that cells will fix aberrant proteins (if possible) before trashing them, but examples remain limited. Our new study by @MichaelMcKenn15 describes how corrective protein quality control by the P5A-ATPase ATP13A1 prevents wasteful ERAD.
authors.elsevier.com/a/1fzWJ…
Christianson Lab retweeted
The translocon component SEC62 has a fascinating second life as ER-phagy receptor (Fumagalli et al 2016, Loi et al 2019). In our last work, we show that SEC62 is at the intersection between ER-phagy and Nucleo-phagy.
biorxiv.org/content/10.1101/…
Christianson Lab retweeted
15th ER & Redox Club Meeting! Created 30 years ago by Ineke Braakman, Bob Sitia, Neil Bulleid. A meeting where stories are told by who did, or is doing the job, students and PostDocs. This means mostly unpublished stuff. Hosts: @Carmine21678 Settembre & Maurizio @MolinariLab
Christianson Lab retweeted
Delighted to share our latest work where we reveal how a gigantic ubiquitin ligase prevents cell death and is itself inhibited biorxiv.org/content/10.1101/…
Christianson Lab retweeted
Latest review from the Carvalho Lab is out in CSH Perspectives, showcasing the exquisite complexity and versatility of ERAD and the essential roles E3 ligase complexes play in this process. Get it while it's hot!
@LogesK @Dunn_School
cshperspectives.cshlp.org/cg…
Christianson Lab retweeted
ERAD/Ub and Ub like modifications/protein biogenesis and homeostasis; Ron Kopito @Stanford, Pedro Carvalho@Dunn_School, John Christianson @ERADLab, Ub regulation in inflammation; Paul Elliott @BiochemOxford,
Christianson Lab retweeted
A study in @NatureCancer implicates a targeted strategy for solid tumors, including breast, brain, pancreatic and ovarian, whereby small, orally bioavailable molecules targeting LIPA block protein folding, induce ER stress and result in tumor cell death. go.nature.com/3tf948y
