Mechanics of cell division across length scales. We shoot cells with lasers. | Physics Department @ NCSU.
Raleigh, NC
Joined July 2016
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Sad to say goodbye to @MBLScience (and the @pco_imaging camera) this morning! Here’s one more superfast contraction as we hit the road - this time vorticella. Thanks to @viboud for sharing the pond water!
Having so much fun using a @pco_imaging camera to watch Spirostomum contraction on a @zeiss_micro rig at the @MBLPhys course. This thing is mindblowingly fast!
Excited to be at the dynamic kinetochore meeting @DKW2022 in Oslo! Will do my best to focus on the talks despite this distracting view
Had a blast learning how to pull needles and try out micro injection this morning @MBLScience after an amazing virtual demo from Adair @sutter_instrmnt before we got here. Thanks again to @MBLPhys for letting us share some equipment and to @leicamicro for the scope!
Excited to me visiting some collaborators at @MBLScience this summer! Got to play with the @LUMICKS_nl trapping system today - amazed to see how streamlined this is compared to the home built system I used in grad school.
Excited to be at #bps2022. No better spot than SF to go from early morning grantwriting to amazing conversation with science friends
By pharmacological inhibition, we found that Kif15 helps crosslink k-fibers together, but that its motor activity is *not* required for this function, leading us to a model that looks something like this.
15/17
In fact, Marc found that, when a k-fiber does splay after ablation, it usually seems to be because a motor called dynein is pulling on it and prying it apart. When we inhibit the recruitment of dynein through depletion of its binding partner NuMA, we see less splaying.
13/17
He found that each of those things - splaying and holding together - happens about half the time. Now, this is interesting, because it suggests that the k-fiber is strong enough to support itself, but not TOO strong.
11/17
