@ExistWell

Associate Professor at @HopkinsMedicine; PhD; Science of psychedelics and other altered states of consciousness @TheYadenLab @JHPsychedelics @psychedelethics

 Johns Hopkins University
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Joined February 2009
  • Tweets10.2K
  • Following798
  • Followers7.3K
525Media
Is the psychedelic hype bubble about to burst? Might that be best for the field? In a new @JAMAPsych article w/ me, @jpotash1, & R. Griffiths, we argue for moving beyond overly negative AND positive extremes to embrace the actual evidence @JHPsychedelics jamanetwork.com/journals/jam…
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Sean Goldy@SeanPGoldyOct 21
📣 Check out these results and more in our new Psychopharmacology article: link.springer.com/article/10…
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Sean Goldy@SeanPGoldyOct 21
We asked how helpful these strategies were for coping. Among antidepressants, escitalopram (3.7 out of 5, n=7), citalopram (3.7, n=3), and fluoxetine (3.4, n=9) scored highest. The most-used supplements, NAC and acetyl-L-carnitine, averaged 2.7 and 2.6.
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Important work by Dr. @SeanPGoldy et al. to understand the side effects of MDMA doi.org/10.1007/s00213-026-0…
Sean Goldy@SeanPGoldyOct 21
‼️ New paper! MDMA "blue Mondays" & "suicide Tuesdays" are familiar phrases in recreational MDMA culture, describing low points in the days post-use. But do these aftereffects actually exist? Current research shows conflicting results. Thread👇
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Sean Goldy@SeanPGoldyOct 21
• Coping strategies: 30% had tried supplements (mostly NAC, acetyl-L-carnitine, magnesium), and interestingly 5% used antidepressants specifically to cope, hinting at preclinical findings on SSRIs mitigating MDMA-induced depletion of serotonin
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Sean Goldy@SeanPGoldyOct 21
🔬 As MDMA-assisted therapy keeps moving toward the clinic, understanding what happens post-treatment matters. So, we (@kelcy_audra, @ExistWell, & @sdpnayak) surveyed 497 US adults with MDMA experience to better understand the phenomenon. Some takeaways:
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As psychedelic treatments approach potential FDA approval, psychiatrists need to be ready for patients’ questions. To help prepare them, Johns Hopkins, Yale, NYU, and Columbia developed a standardized psychedelic medicine curriculum for psychiatry trainees. The first multi-site evaluation of the course was just published in Academic Psychiatry. After the course: 💡 Confidence counseling patients about clinical research and legal care nearly doubled 🔬 Understanding of the limitations of current evidence rose sharply 📈 Knowledge quiz scores improved ⚖️ Trainees gained a more balanced, critically informed view of the evidence, without inflated enthusiasm for the field We’re continuing to develop educational and training programs for professionals across a range of fields, so stay tuned! doi.org/10.1007/s40596-026-0…
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New paper 🚨The Need to Clarify Regulation of Mental Health Artificial Intelligence | JAMA Psychiatry. Led by Will Smith
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William Choi@willjwchoiOct 16
doi.org/10.1007/s12152-026-0… Beyond excited to announce this piece just published in @NeuroethicsJ! During my research year at @JHPsychedelics, I had the privilege to co-facilitate prep, dosing and integration sessions for a number of participants in one of the psilocybin trials

Clarifying “Psychotherapy” and “Psychological Support” in Psychedelic Clinical Trials: The What,...

Neuroethics - A growing debate in psychedelic clinical research concerns whether facilitators (1) do administer psychotherapy (PT) or merely psychological support (PS) to trial participants, and...

link.springer.com
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Are psychedelics anti-inflammatory!? I am beyond excited to present the first systematic review and meta-analysis of the immunomodulatory effects of serotonergic psychedelics! sciencedirect.com/science/ar…
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New paper in JME Practical Bioethics: Katherine Cheung @Katherine_Chg, Edward Jacobs @eddietalksdrugs, and David Yaden @ExistWell review the ethics of psychedelic clinical trials and flag key concerns to resolve as psychedelics move toward real-world care. jmepb.bmj.com/content/2/4/e0…
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Daniël Lakens@lakensOct 9
The Paul Meehl Graduate School Symposium is kicking off with a keynote by the Best Thesis Award winner Charlotte Rulkens on the role of replications in the Humanities, studying the repetition of art attribution.
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BryanRoth
@zenbrainestOct 9
This is huge!! @NIMHDirector will allocate $$$ to fund, essentially, clinical trial networks for #psychedelics and other rapidly-acting psychoactives (#ketamine #mdma ) grants.nih.gov/grants/guide/…
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A comprehensive review of bioethical progress and need for further work on psychedelic research and potential clinical applications across screening, informed consent, dosing, follow-up, & more. Work led by @Katherine_Chg w/ @eddietalksdrugs and me. Check out the thread and link:
Katherine Cheung@Katherine_ChgOct 9
A growing body of bioethical work has examined ethical issues related to the use of psychedelics in clinical research. With @eddietalksdrugs and @ExistWell, we try to take stock in our state-of-the-field review, published in JME Practical Bioethics.
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Katherine Cheung@Katherine_ChgOct 9
We organize the literature here by trial stage (e.g. screening, informed consent, dosing, follow-up), in addition to identifying cross-cutting concerns.
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Katherine Cheung@Katherine_ChgOct 9
A growing body of bioethical work has examined ethical issues related to the use of psychedelics in clinical research. With @eddietalksdrugs and @ExistWell, we try to take stock in our state-of-the-field review, published in JME Practical Bioethics.
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Psychedelics are such a common subject of discussion in medical and clinical contexts, that an understanding of the state of science is useful for any clinician. Here is a way to learn about psychedelic science and medicine:
Johns Hopkins Psychedelic Research Center
@JHPsychedelicsOct 2
What should clinicians know about psychedelic-assisted treatments? Learn from our experts and earn 6.5 CME/CE credits! 🔗 ⬇️ Fri, Oct. 9th | Online | 8:45am-4:30pm ET hopkinscme.cloud-cme.com/cou…
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Sure! Not either/or here
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Psychedelics are a common subject in medical and clinical contexts these days. This CME course provides an overview of the scientific state of the evidence. It is led by clinicians and scientists at @JHPsychedelics and one of the most efficient ways to get a sense for the field:
Johns Hopkins Psychedelic Research Center
@JHPsychedelicsOct 6
Just 2 days away from our online CME/CE course on psychedelic-assisted treatments, taught by our clinicians and expert scientists! Join us on Friday, Oct 9th from 8:45am-4:30pm ET. More info and registration link below! hopkinscme.cloud-cme.com/cou…
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Just 2 days away from our online CME/CE course on psychedelic-assisted treatments, taught by our clinicians and expert scientists! Join us on Friday, Oct 9th from 8:45am-4:30pm ET. More info and registration link below! hopkinscme.cloud-cme.com/cou…
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David B. Yaden retweeted
Vidita Vaidya@ViditaVaidyaOct 5
This one has been a long time coming - along with optogenetics, chemogenetics and the development of powerful sensors have been game changers for neuroscience.
The Nobel Prize
@NobelPrizeOct 5
BREAKING NEWS The 2026 #NobelPrize in Physiology or Medicine has been awarded to Karl Deisseroth, Peter Hegemann and Georg Nagel “for their discoveries concerning light-gated ion channels and optogenetics.”
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