Ph.D. Student @JanMasekLab, at @CharlesUniPRG, @Prague
Prague
Joined October 2021
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Fabio Turetti retweeted
🧬 If you’re at #NotchMeetingXIII, don’t miss Poster #36 by our talented PhD student @FTuretti from the @JanMasekLab
He’s presenting “CK1α-Dependent Phosphorylation of NOTCH1 Is Required for Transcriptional Activity of N1ICD.”
Come by, say hi, and chat Notch signaling! 🔬✨
Fabio Turetti retweeted
Just published in our NOTCH signaling community!
Contrary to expectations, the study by Timothy Vanderleest and the team found pericytes don't reduce connections when Notch3 signaling is disrupted—they form deeper "peg-and-socket" junctions instead!
Fabio Turetti retweeted
Genetic disorder #ALGS affects newborns' livers. @JanMasekLab and colleagues uncovered how immature #hepatocytes & #Tregs contribute to pericellular #fibrosis in ALGS.
Read more in @EmboMolMed!
🔗embopress.org/doi/full/10.10…
(TŽ)
ALT Description: Figure explaining the mechanisms of atypical liver syndrome in ALGS Source: The original study
Fabio Turetti retweeted
Happy to share that our article "Cell type and regulatory analysis in amphioxus illuminates evolutionary origin of the vertebrate head" has just been published in Nature Communications rdcu.be/dWVEN
We show #neuralcrest-like and prechordal plate-like cells in amphioxus!
Fabio Turetti retweeted
🧵1/8 Excited to share our latest research published in EMBO Molecular Medicine! We explored the specific, pericellular fibrosis in Alagille syndrome (ALGS). #Fibrosis #ALGS #LiverDisease #EMBO
doi.org/10.1038/s44321-024-0…
Fabio Turetti retweeted
Direct interaction of enigmatic Notch1-intracellular domain and subsequent signalling revealed by @FTuretti from @JanMasekLab.
Fabio Turetti retweeted
This Third Thumb is *so cool*. I am unbelievably jealous of the folks who got to try it out! That story and more of the best in @ScienceMagazine and science in this edition of #ScienceAdviser: science.org/content/article/…
Video credit: Dani Clode Design and the Plasticity Lab
Fabio Turetti retweeted
The DevCellBiol PhD event our students at @PrirodovedciCZ organized was a blast! Big thanks Misa Liegertova for a great talk on AI in research l1nq.com/nnCpR and @imgprague for hosting the event! Congrats to best poster winners! @EHudacova @FTuretti and @irinaribeirobas
Fabio Turetti retweeted
Please check the open phd positions at our faculty! There are great projects in there!
📢 Enhance your research journey with our STARS PhD positions in Biology!
📆 Applications are due by March 13, 2024!
stars-natur.cz/phd-positions…
Fabio Turetti retweeted
Fresh from the publishing oven, our new review on how Jagged1-Notch signaling mediates development, and JAGGED1-driven Alagille syndrome. Big thanks to @EmmaRAndersson, our editor @DavidSprinzak, and the reviewers for insightful comments! shorturl.at/bsA56
#devbiol #liver
Fabio Turetti retweeted
Beyond happy from succeeding in securing GACR funding for the Wnt x Notch crosstalk research project we devised with @Jakub_Harnos! Won't be there without our lab members @FTuretti and Hana Hajsmanova! Big thanks to the agency for supporting us!
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Fabio Turetti retweeted
And that’s a wrap!
#devcellbiophd
Huge thanks to the speakers @Fruitflyfriend @DeriveryLab, sponsors @DianaBiotech @NF_IOCBTech @science_charles Baria, and participating students 🙌🏽
Until next year!
@FTuretti @tomasova42 @JanMasekLab @anna_frontino94 @ReiForna @CharlesUniPRG
Fabio Turetti retweeted
"ColabDock: inverting AlphaFold structure prediction model for protein-protein docking with experimental restraints"
Use experimental restraints as losses & back-propagating to input sequences. Wonder how many sequence changes are introduced to fit data?
biorxiv.org/content/10.1101/…
Fabio Turetti retweeted
So the adventure begins. Huge thanks to @DavidSprinzak for the opportunity to experience Israeli science environment in his laboratory! Big thank you goes to all the members of my @JanMasekLab, and certainly to @cenaneuron for making this experience come true. I'm beyond excited!
Studentka @UniKarlova @ETrampotova míří na letní stáž @TelAvivUni, kde se v rámci programu Neuron & IOCB Tech Internships in Israel zaměří na řešení příčin Alagillova syndromu nebo biliární atrézie.
Společně s @NF_IOCBTech přejeme šťastnou cestu a inspirativní pobyt!
Fabio Turetti retweeted
Our 2nd exciting joint project with the power duo @chrmosimann & @aburger2009 is now at biorxiv.org/content/10.1101/…
Last time @KozmikLab made transgenic #amphioxus for nature.com/articles/s41467-0…, this time we made a triple enhancer KO in mice. That’s what I call lab flexibility.
Fabio Turetti retweeted
when you're waiting for the centrifuge and you randomly start questioning the entire project
Fabio Turetti retweeted
Come to @BIOCEV_science and find out what can your future look like after PhD!
Our next #SharingCzexpats workshop is co-organized with the @IBT_CAS and is suitable for PhD students, postdocs, but also for motivated Master's students who are considering applying for PhD.
Do you study a PhD program or are you considering to join one? Still unsure, what the degree will be useful for and how your career may look like if academia is not your cup of tea?
Find answers at our next #SharingCzexpats workshop👇
sharing.czexpats.org/2023-no…
Fabio Turetti retweeted
I am happy to finally share my main PhD first-author paper from Helena Karlström lab ( (twitterless), where we show that active immunization with a small mutated NOTCH3 peptide led to the reduction of NOTCH3 aggregation surrounding the brain capillaries!
Online today! Active immunotherapy reduces #NOTCH3 deposition in brain capillaries in a #CADASIL mouse model
By U Lendahl, H Karlström & colleagues @karolinskainst
🗞️doi.org/10.15252/emmm.202216…
Fabio Turetti retweeted
Why do children with the liver disease Alagille syndrome (ALGS) bleed spontaneously?
What exacerbates bleeding risk?
Can blood vessel anomalies be detected in patients non-invasively?
Our work addressing these questions is out now:
doi.org/10.15252/emmm.202215…
