Chief Medical Officer, Novo Nordisk; Professor of Endocrinology, University of Copenhagen. Views are my own.

Gentofte, Danmark
Joined September 2019
Filip K. Knop retweeted
🧠Meet Dr. Liva Krogh (@Metabolcenter), co-investigator & grant recipient of the #EFSD/ @novonordisk A/S Programme for #Diabetes Research in 🇪🇺. Their project investigated how the incretin hormones GIP & GLP-1 act on tissues outside the pancreas. More 👉 europeandiabetesfoundation.o…
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Today, @HannahVigh et al. unleash a freely available and searchable database of the human intestinal transcriptome - an atlas of the expression of 19,739 genes from 16 sites along the intestinal tract. Check out the landscape of your favourite gene here: rnaseq.gubra.dk
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🌍 For Half of Humanity: Why we need action on obesity Obesity is one of the defining global health and equity challenges of our time. Today, over 1 billion people live with obesity, and without bold action, 4 billion - half of the world’s population - will be affected by overweight or obesity by 2035. This campaign is our urgent call to action in the lead-up to the 2025 UN High-Level Meeting on Non-Communicable Diseases (HLM on NCDs). Our goal is clear: to secure global recognition of obesity as a chronic disease, drive equitable access to care, and catalyse multisectoral solutions. Obesity doesn’t just impact individuals - it fuels a wider crisis of non-communicable diseases including diabetes, heart disease and cancer. And it’s not just a high-income country issue - 88% of future obesity cases will occur in low- and middle-income countries. But we have the tools to act: proven public health policies, emerging treatments, and growing political momentum. The HLM must our moment to demand action. Join us in demanding: ✅ Obesity recognised as a disease in the HLM Political Declaration ✅ Commitment to WHO recommendations & Acceleration Plan ✅ People with lived experience at the heart of global solutions 🌐 Visit our website to explore campaign materials, take action, and learn why this moment matters. We have #4BillionReasons to act. 🔗 worldobesity.org/HLM4 #4BillionReasons #HalfOfHumanity
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And you thought #metformin lowered glucose via the liver? Here loss-of-function and gain-of-function studies suggest that VMH Rap1 is indispensable for the antidiabetic effects of metformin in mice #diabetes science.org/doi/10.1126/scia…
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A new comprehensive review of the proglucagon-derived peptides #disbetes #obesity #shortbowelsyndrome journals.physiology.org/doi/…
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Adult & Pediatric Populations in a Cohort of At-Risk Relatives in The T1D TrialNet Pathway to Prevention Study ➡️Still more to learn on trajectories of single antibody positivity… however stage 2 T1D and progression more defined in adults or children diabetesjournals.org/care/ar…
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Roles for VAMP-8 in GLP-1R recycling in beta cells diabetesjournals.org/diabete…
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Filip K. Knop retweeted
#PRESS: At #ADA2025, Novo Nordisk is sharing the full phase 3 study results in people with overweigh or obesity, and overweight or obesity and type 2 diabetes respectively. Both studies simultaneously published in The New England Journal of Medicine. Read the full press release

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The Banting Award for scientific achievement to Professor Steven Kahn. A stellar career with scientific leadership across multiple domains #diabetes A poignant celebration unfolds #ADA2025 @AmDiabetesAssn
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GDF15 is still a mystery hormone: Trends in Endocrinology & Metabolism Now finally out in print! cell.com/trends/endocrinolog…
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Go with the flow-endogenous GIP and splanchnic blood flow in humans diabetesjournals.org/diabete…
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MARCH2, an E3 ubiquitin ligase, safeguards against metabolic dysfunction-associated #fattyliver disease. By promoting FASN degradation, MARCH2 reduces #hepatic #lipogenesis and steatosis, highlighting a potential therapeutic avenue for #MAFLD. 🔗sciencedirect.com/science/ar…
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Filip K. Knop retweeted
Increased risk of 13 different cancers with an elevated BMI @NEJM #obesity
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