Physician-Scientist, investigating innate immunity in cardiovascular disease @uniklinik_hd
Heidelberg, Germany
Joined August 2020
- Tweets39
- Following333
- Followers180
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Florian Sicklinger retweeted
No longer the forgotten valve.
Check out our latest preprint on how tricuspid regurgitation accelerates heart failure.
doi.org/10.64898/2026.07.07.…
Florian Sicklinger retweeted
cool paper alert
👇
biorxiv.org/content/10.64898…
Using the first mouse model of tricuspid valve regurgitation, we identify a cardio-intestinal innate immune circuit in which chronic venous congestion reprograms monocytes into IL-6-producing drivers of heart failure.
doi.org/10.64898/2026.07.07.…
Florian Sicklinger retweeted
Do we study the right biology after myocardial infarction (MI)?
• Surgery in standard mouse model masks MI-specific immune responses
• Minimally invasive model better reflects patient immune responses & reveals immature neutrophils worsen heart function
tinyurl.com/MImodels
Florian Sicklinger retweeted
#SpatialOmics #MyocardialInfarction
#MolecularCartography 100-gene + #SeqIF 12-marker + #DeepVisualProteomics
4/24/49/96 h postMI🐭
Endocardial vWF mediates Mɸ infiltr
Anti-vWF i.v. reduces Mɸ at endocardial, but not epicardial, core or border, zone, but causes infarct wall thinning + worsened cardiac adaptation by 2 wk
Cellpose 2 human-in-a-loop for CardioMyocyte segmentation
Ankrd1 pixel cluster to demarcate stressed/dying CM
Custom analysis pipeline
github.com/SchapiroLabor/mi_…
@flowuenne @FloSicklinger @DenisSchapiro @NatureCVR 2025
nature.com/articles/s44161-0…
Florian Sicklinger retweeted
von Willebrand factor is upregulated after myocardial infarction and facilitates recruitment of Ccr2+ monocytes that worsen cardiac function
@flowuenne @FloSicklinger @DenisSchapiro
nature.com/articles/s44161-0… @NatureCVR @HeidelbergU @uniklinik_hd 🇩🇪
Florian Sicklinger retweeted
Please join us for our 2nd Immuno-Cardiology Symposium in beautiful Bar Harbor, Maine, Sept. 18-19! @jacksonlab @MDIBL explore how dysregulated immune system function contributes to inflammation and fibrosis in disease and related disorders in the kidney, lung and liver
Florian Sicklinger retweeted
Sicklinger & colleagues developed a new #ultrasound-guided method to induce #HeartAttacks in mice, allowing precise control & real-time monitoring without the need for invasive surgery. Learn more at ahajrnls.org/42R7ZGs
@volkersmirko @junedh_amrute @rkramann
Florian Sicklinger retweeted
Check out the latest issue of @CircRes with our Echo-Guided IR Method on the cover ♥️ 🥢
@CircRes May 9th Issue is Out! ahajrnls.org/3wPOBJJ
Cover: Representative IF staining of endothelial cells (magenta), inflammation (yellow), & WGA (green) in a 4-chamber view of a heart 7 days after Echocardiography-Guided Induction of I/R;nuclei-blue.
In @Circres we describe a novel Echocardiography-Guided Method for Induction of Myocardial Ischemia/Reperfusion.
Check out the full study here: doi.org/10.1161/CIRCRESAHA.1…
Great collaborative effort with @leuschnerlab, @lavinelab, @jacksonlab @rkramann @dzhk_germany @ImmunoFibHF
Florian Sicklinger retweeted
In @Nature we use single cell multiomics, fibroblast fate tracing, and in vivo models to characterize immune fibroblast crosstalk in heart failure with @LavineLab @washumedicine, @Amgen , and @ImmunoFibHF nature.com/articles/s41586-0…
Florian Sicklinger retweeted
Check out our paper just published in Circulation
➡️ Translation controls inflammation after myocardial infarction
doi.org/10.1161/CIRCULATIONA…
This work was a huge collaborative effort over many years.
@dzhk_germany @DGK_org @VolkersMirko
Key findings + paper summary below 🧵⬇️⬇️⬇️
Florian Sicklinger retweeted
Very happy that our manuscript is now online @CircAHA. Transient inhibition of translation protects against #reperfusion injury. Kudos to first author @ChrlsHofmann and to all Co-authors for a great team effort. @CRC1550 @dzhk_germany @uniklinik_hd ahajournals.org/doi/abs/10.1…
Thanks to @BronwynBerkeley for highlighting our method in @NatRevCardiol
Read my Tools of the Trade article, published in @NatRevCardiol, highlighting my experience with and the method of ultrasound guided induction of myocardial infarction:
rdcu.be/dLgU3
Thanks to @FloSicklinger & F. Leuschner for developing such an innovative method.
Florian Sicklinger retweeted
A shortcut to the infarcted heart
Excited to share our collaborative effort with @DenisSchapiro lab led by @FloSicklinger and @FloWuenne. Using spatial omics technologies, we found a new way how monocytes sneak into the infarcted heart.
biorxiv.org/content/10.1101/…
Florian Sicklinger retweeted
I am very excited to share our lab's first preprint @uniklinik_hd together with the @LeuschnerLab. This study was led by @FloWuenne and @FloSicklinger. biorxiv.org/cgi/content/shor…
Florian Sicklinger retweeted
🩵💙🩵💙great symposium - great people - great location!! 🩵💙🩵💙#ImmunoCardiology @jacksonlab #leducq #immunofibHF
Florian Sicklinger retweeted
Florian Leuschner Kicking off the first US immunocardiology conference at @jacksonlab. @ImmunoFibHF
Very excited about what’s in store the next three days! #CardioTwitter #cardioimmunology
