
Associate Professor @Penn • Dept Psychiatry + Dept Neuroscience + Dept Anesthesiology | Pain • Placebo • Poppies • Psychedelics
Philadelphia, PA
Joined March 2016
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🧠⚡️💊New @Nature publication !
Mimicking opioid analgesia in cortical pain circuits
We built a brain-behavior framework to decode spontaneous chronic pain in mice—and to biologically mimic morphine with a synthetic opioid gene therapy
nature.com/articles/s41586-0…
@PennMedicine
Researchers identify the neurons involved in the emotional distress associated with pain
go.nature.com/3NkL1SB
⚡️GREG_CORDER⚡️ retweeted
U.S. national primate research centers face an uncertain future. The U.S. has been disinvesting in primate research, which is indispensable for translating brain and mental health discoveries into treatments for people. Mouse neurology is great for discovery using an amazing methodological quiver, but it's hard to scale the insights, technologies, and treatments to humans. Unfortunately, we face stiff competition from other countries. “China’s already been eating our lunch; they’re going to eat our dinner, too,” says Michael Platt, university professor of psychology at the University of Pennsylvania. China’s investment could lead to new vaccines and treatments and cures for brain disorders—but “it’s not clear that you get to share in the fruits of those discoveries.” The U.S. must step up and fund this vital national resource. thetransmitter.org/what-if-n…
⚡️GREG_CORDER⚡️ retweeted
Excited to share my lab’s latest preprint led by postdoc @YukiHaba_ and grad student Ryan Schwark. We surprisingly find that spontaneous behavior in isolation predicts a naked mole-rat’s identity, its colony membership, and even rank within its colony.
biorxiv.org/content/10.64898…
⚡️GREG_CORDER⚡️ retweeted
Take away the wanting-it-to-stop and see what's left of the pain. Dennett says: nothing.
The Partially Examined Life · Ep. 400: Dennett Rejects Qualia (Part Two)
⚡️GREG_CORDER⚡️ retweeted
PRF Webinar Pain in Women youtu.be/fjXukpoKQhU?si=cDD1… via @YouTube
⚡️GREG_CORDER⚡️ retweeted
Illusionism is a terrible name for it. Nobody is saying your experience isn't happening — they're saying it isn't what it advertises itself as.
The Partially Examined Life · Ep. 399: Dan Dennett’s Model of Mind (Part Two)
🚨🧠📄 @biorxivpreprint: L5 ACC engages dlPAG to facilitate affective pain
First, map opioid+ pain ACC neurons: nature.com/articles/s41586-0…
Next, ID endogenous opioid control across the PAG: pmc.ncbi.nlm.nih.gov/article…
Now, we link the ACC→dlPAG circuit: biorxiv.org/content/10.64898…
7/8 ACC activity also tracked spontaneous pain-directed behaviors as they unfolded
That brings us closer to the ongoing affective-motivational experience of chronic pain
8/8 🌎 The bigger goal: precision pain control in nociceptive x mu-opioid circuits
Via our gene therapy to mimic opioid analgesia in the circuits where it works, or harness placebo to recruit endogenous opioids:
cell.com/neuron/fulltext/S08…
Launching scienceofplacebo.org: a living bibliography of placebo and nocebo research. New papers screened & tagged daily by design, population, outcome and findings, with a searchable database (currently about 5,000 papers), an interactive researcher map, events, news and discussion.
⚡️GREG_CORDER⚡️ retweeted
Excited to share spatial NT-seq, now out @NatureNeuro! By distinguishing newly synthesized from pre-existing RNA, this method turns static snapshots of total RNA into spatially resolved views of RNA life cycles. @PennGenetics @PennEpiInst @PennMedCSO
nature.com/articles/s41593-0…
⚡️GREG_CORDER⚡️ retweeted
Incredibly proud to share our newest work where we developed a multiscale spatial transcriptomic atlas of the human amygdala using three complementary technologies! 1/12 🧵 biorxiv.org/content/10.64898…
⚡️GREG_CORDER⚡️ retweeted
The Ehrlich Lab is now online! 🎉
I’m excited to share the new website for my laboratory at VCU’s SLSS. Learn more about our research on GPCR signaling, receptor trafficking, and neuromodulation and find information about opportunities to join the lab.
sites.google.com/view/ehrlic…
Cover!
Check out the paper here: cell.com/neuron/fulltext/S08…
New issue of Neuron online! The cover features work from Matthew Banghart, Lin Tian, and colleagues, who cleverly "trick" mice into producing a placebo-like anesthesia effect. They show placebo anesthesia uses similar circuits and molecules as morphine.
cell.com/neuron/current
⚡️GREG_CORDER⚡️ retweeted
New issue of Neuron online! The cover features work from Matthew Banghart, Lin Tian, and colleagues, who cleverly "trick" mice into producing a placebo-like anesthesia effect. They show placebo anesthesia uses similar circuits and molecules as morphine.
cell.com/neuron/current
















