A human-AI collaboration to map the fly brain. Explore the connectome in Codex: https://teapawt.net/t.co/Ea0fpOXjxF
Princeton University
Joined August 2019
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FlyWire retweeted
Modelling the whole fly brain from just the connectome and thinking that reveals something about fly behaviour, is a bit like modelling traffic flow out of Google maps and thinking you understand the world economy. Not unrelated, but not that close.
FlyWire retweeted
Meyve sineği beynini TCMB’ye bağladım ve faiz kararını belirlemesini istedim. Sinek, insana göre genelde daha düşük faiz kararı belirledi ve enflasyon oranı benzer çıktı.
FlyWire retweeted
But can it run DOOM?!
Well...actually, yes.
For the first time, scientists have mapped the complete brain and central nervous system of an adult male fruit fly — a key model organism in science. 🪰
Working alongside HHMI Janelia Research Campus and the scientific community, @GoogleResearch scientists and researchers used AI to combine millions of 2D images into 3D neural shapes, reconstructing a record-breaking 166,000+ neurons. This foundational map of the adult male fruit fly brain can help accelerate our understanding of the brain, and is a major milestone in neuroscience.
ALT Vibrant 3D digital reconstruction of a fruit fly brain against a white background, displaying a dense, intricate network of multicolored neural fibers and cell bodies in shades of blue, cyan, orange, and purple.
ALT A complex 3D visualization of a fruit fly brain, featuring a dense, symmetrical network of thousands of tiny, multicolored neurons and fine, interconnected fibers in shades of blue, magenta, orange, and green against a solid white background.
FlyWire retweeted
Step inside a fly and follow sight, walking, steering & grooming circuits! Powered by @FlyWireNews BANC, a wiring map of a fly’s brain and central nervous system published in @Nature this June. Yesterday brought MaleCNS in @CellCellPress from @hhmi_science @GoogleResearch, an invaluable male counterpart. Now for comparative connectomics!
FlyWire retweeted
Just published yesterday, the #BANC! A full central nervous system (CNS) connectome of a limbed animal enables us to trace sensory-motor arcs and understand how the CNS controls the body. rdcu.be/fncjS #neuroscience @Nature, Video by @quorumetrix, sound on! 1/18
FlyWire retweeted
We've uploaded a fruit fly. We took the @FlyWireNews connectome of the fruit fly brain, applied a simple neuron model (@Philip_Shiu Nature 2024) and used it to control a MuJoCo physics-simulated body, closing the loop from neural activation to action.
A few things I want to say about what this means and where we're going at @eonsys. 🧵
FlyWire retweeted
Mala and I will be delighted to accept this award on behalf of the FlyWire Consortium of 75 laboratories and citizen scientists around the world!
Congratulations to FlyWire founders @SebastianSeung and @MurthyLab, who alongside John White and Gerald Rubin have been recognized with the Wiley Prize for their work pioneering connectome reconstruction & interpretation!
FlyWire retweeted
The Institute for Advanced Study (@the_IAS), the fabled home of Einstein and Gödel, announces a 2026-27 program on Modeling Fly Vision, intended to refound theor/comp neuro on the bedrock of 21st century brain maps. Apply for membership! ias.edu/sns/csb#special-year
FlyWire retweeted
Our Method of the Year 2025 is...drumroll please...EM-based connectomics!!
Our Editorial introduces our choice and highlights six Comments and other related content in this special issue. Please join us in celebrating EM-based connectomics! 🎉🧠🔬
nature.com/articles/s41592-0…
FlyWire retweeted
Method of the Year 2025: A Comment from @MurthyLab showcases how complete connectomes can yield hypotheses about circuit function and generate predictions that can be tested with genetic tools, as illustrated with examples from the Drosophila community.
nature.com/articles/s41592-0…
FlyWire retweeted
Method of the Year 2025: A Comment from @martamcosta2 discusses challenges and prospects of comparative connectomics, which provides insights into variability between individuals, changes during development, differences between sexes and evolutionary changes between species.
FlyWire retweeted
Method of the Year 2025: In his Comment, @janfunkey discusses current challenges in connectomics, which is time-consuming and labor-intensive. He focuses on proofreading and discusses how automated models might be further developed to embrace uncertainty.
nature.com/articles/s41592-0…
FlyWire retweeted
Method of the Year 2025: In their Comment, Wei-Chung Allen Lee @darbly and Ramin Khajeh discuss alternatives to the well-established approaches used in connectomics.
nature.com/articles/s41592-0…
FlyWire retweeted
Over a year ago, the surprising complex brain of the humble fruit fly was mapped after a decade of work. 🪰✅
The ~300 person team was led by @princeton and incl. #ElectronMicroscopy experts from @AllenInstitute.
🔗 princeton.edu/news/2024/10/0…
Video: @quorumetrix @flywirenews
FlyWire retweeted
Last year we published the neuronal wiring diagram of a fruit fly brain. This was a huge advance, but something important was missing: the ventral nerve cord (VNC). The VNC is the brain-body interface, analogous to our spinal cord. teapawt.net/FlyWireNews/status/184…
Big news! The fly connectome is featured on the cover of a special edition of Nature.
This is all possible thanks to the collaboration of 292 members of The FlyWire Consortium!
nature.com/immersive/d42859-…
Check out the thread for an overview of the 9 #flywire papers published today
FlyWire retweeted
#FlatironCCM researchers Daniel Lee and Lawrence Saul recently won @FlyWireNews' Ventral Nerve Cord Matching Challenge! The challenge asked participants to construct a method for aligning the neural networks of a male and female fruit fly. simonsfoundation.org/2025/03… #math #science #AI
FlyWire retweeted
🧠 ¿Qué tienen en común las moscas de la fruta y la inteligencia artificial? Todo.
En nuestro último episodio para la noche de reyes, exploramos el conectoma completo de la mosca y su impacto en la neurociencia y la tecnología. 🧵👇 #Conectómica @FlyWireNews
FlyWire retweeted
We are pleased to report publication of the Drosophila circadian clock connectome in @NatureComms . Check out the final version for additional analyses not present in the preprint. @unrcabnr @unrbmb nature.com/articles/s41467-0…
FlyWire retweeted
The @FlyWireNews project — mapping the entirety of a fruit fly brain, led by #PrincetonU scientists — has been named as part of @NatGeo's top 2024 science moments "that will shape the future." on.natgeo.com/4giqDdZ
FlyWire retweeted
I've combined some of these together into a new #neuro #visualization "In the eye of a fly":
Using the @FlyWireNews visual system wiring diagram, #Brian2 spiking #neuron simulator, and #blender. Information flow through the chiasms, across a topographic map.