Bioinformatics & Computational Biology @ University College London @ISMBInstitute @ucl
London, England
Joined March 2018
- Tweets129
- Following66
- Followers176
- Likes28
Fraternali Lab retweeted
Another preprint @FraternaliLab: We explored how the antibody framework (i.e. parts of variable region away from Ab-Ag interface) can be exploited to fine-tune antibody effector functions. V enjoyable in vitro/in silico collab @ffrancafrat @SophiaKaragiann biorxiv.org/content/10.1101/…
Fraternali Lab retweeted
Happy to share new work @FraternaliLab led by @Dongjun_Guo - exploring how antibody heavy and light chains form specific pairs. We fine-tuned an antibody language model to predict pairing, and asked how pairing propensities change during B cell maturation and in diseases.
Fraternali Lab retweeted
Congratulations to Guillem for winning a prize for his poster on double negative/atypical memory B cells in SARS-CoV-2 mRNA vaccination at the @iit_ucl symposium 2024 🎉👏
Fraternali Lab retweeted
We present VCAb, a new web interface for performing different structure-based explorations towards aspects of antibody engineering: 🧵(1/7)
📄biorxiv.org/content/10.1101/…
🌐fraternalilab.cs.ucl.ac.uk/V…
Fraternali Lab retweeted
Postdoc available in our lab. B cells, antibodies and class switching. Part of a wider BBSRC sLoLa with @FraternaliLab @Mauri_group jobs.surrey.ac.uk/Vacancy.as…
Fraternali Lab retweeted
Well done to Izzy for winning a prize for her presentation on the single cell analysis of B cells in lung cancer!!👏🫁🧬#WIRM – at Davos, Switzerland
Fraternali Lab retweeted
Very proud to finally see this recent work from my lab out in Nature Methods!
Thanks to a fantastic collaborator like @JosefNg1 and an enthusiastic group of Immunologists!
nature.com/articles/s41592-0…
Fraternali Lab retweeted
Very happy that sciCSR - our new method in analysing B cell Class-Switch Recombination (CSR) in #scrnaseq data - is out @naturemethods - Tweetorial below 🧵
sciCSR developed by @FraternaliLab, @JosefNg1 and colleagues is a computational workflow that uses scRNA-seq data to predict class switch recombination events and B cell dynamics.
nature.com/articles/s41592-0…
Fraternali Lab retweeted
sciCSR developed by @FraternaliLab, @JosefNg1 and colleagues is a computational workflow that uses scRNA-seq data to predict class switch recombination events and B cell dynamics.
nature.com/articles/s41592-0…
Fraternali Lab retweeted
CCPBioSim Biomolecular Simulation at this week's workshop
Thanks to all the trainers that helped in making this a success!
on #structuralbioinformatics resources and tools for #moleculardynamics simulations.
The course is run in association with CoSeC UKRI and STFC.
Fraternali Lab retweeted
Recharged after a long weekend in Yorkshire and excited to travel down to #BSI22. Hopefully quiet train journey now to prepare my talk at the Next-generational tools section tmr on analysing #ClassSwitching in #scRNAseq data! – at Hebden Bridge, England
ALT Nice view of the Rochdale canel at Hebden Bridge
Fraternali Lab retweeted
Happy to share this editorial on the issue in Current Opinions in Structural Biology : Modern and Future Methods for Studying Macromolecular Assemblies in Action coordinated by Alan Brown and myself.
sciencedirect.com/science/ar…
Fraternali Lab retweeted
How does #climate impact biomedical science?
Our response to the climate crisis has implications for allergy & asthma, cardiovascular diseases & cancer biology - all interests of our Randall Centre.
Read part 1 of our #COP26 series by @InSilicoVitro ⤵️
bit.ly/3weu27Z
Fraternali Lab retweeted
COVID-19 patients have ⏫IgG1, but it is underdeveloped. Commonalities across infections. Ebola disease survivors have broad⏫CSR. ⏫ IGHV1 in RSV. With @drmelbailey @ffrancafrat and the Surrey COVID-19 Consortium. biorxiv.org/content/10.1101/…
Fraternali Lab retweeted
Today with @emblebi, we're launching the #AlphaFold Protein Structure Database, which offers the most complete and accurate picture of the human proteome, doubling humanity’s accumulated knowledge of high-accuracy human protein structures - for free: dpmd.ai/alphafolddb 1/
Fraternali Lab retweeted
Is this genetic variant harmful or harmless? @FraternaliLab exploit the interplay between protein structure, proteomic measurements & functional pathways to better discriminate between variants in health & disease @JosefNg1 @ffrancafrat &co #PLOSBiology plos.io/3sXDObb
Fraternali Lab retweeted
Happy that this is now published!
This github contains some functions that add on top of velocyto output to quantify the strength of transitions between clusters: github.com/Fraternalilab/scR…
Distinct B cell development pathways and a reference single cell dataset for B cells in the blood. Our paper our today with @ffrancafrat @JosefNg1 tinyurl.com/yh8dz2ga
Fraternali Lab retweeted
Distinct B cell development pathways and a reference single cell dataset for B cells in the blood. Our paper our today with @ffrancafrat @JosefNg1 tinyurl.com/yh8dz2ga
Fraternali Lab retweeted
The 4th Multiscale Conference will be held online
🗓️29-31 March 2021
➡️ccpbiosim.ac.uk/multiscale20…
Registration is required (no cost) and the deadline is 23 March 2021
@CCP5UK @cecamEvents
#CompChem #CompBio #MultiscaleModelling