@Freyna_STEM

PhD student at @classenlab

 Freiburg im Breisgau, Deutschl
Joined September 2021
  • Tweets19
  • Following143
  • Followers36
Our lab day out was a blast🥳! Ice skating, bowling, and the delicious food left us buzzing with joy❤️. Looking forward to more fun times ahead!#labdayout #teamfun – at Freiburg im Breisgau, Germany
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Have you ever wondered how our tissues stay healthy, and how they are able to identify and remove abnormal cells? Click authors.elsevier.com/sd/arti… @CurrentBiology for the whole story. 1/9 #devbio #cellbio #tumor #axonguidance #cellcompetition #SFB850 #Ras #Drosophila #JNK #teneurin
The image shows a zoomed in part of a wing imaginal disc with ectopic Robo2 expressing cells in cyan, JNK signaling activity in magenta, actomyosin (phalloidin staining) in grey and cleaved Dcp-1 (apoptosis) in yellow.

ALT The image shows a zoomed in part of a wing imaginal disc with ectopic Robo2 expressing cells in cyan, JNK signaling activity in magenta, actomyosin (phalloidin staining) in grey and cleaved Dcp-1 (apoptosis) in yellow.

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Our PhD student @Freyna_STEM did a stellar job presenting @fischericke amazing work on Interface Surveillance at #EDRC2023. Please check out the preprint biorxiv.org/content/10.1101/… Kudos to Friedericke, Anna & team! 👏 – at Lyon, France
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Still buzzing from the vibrant energy at #EDRC2023 in Lyon! Engaging presentations, insightful discussions, and meeting brilliant minds - an enriching experience. Huge thanks to the organizers! Looking forward to #EDRC2025 🔬 – at Lyon, France
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#TissueDamage induces spatially distinct patterns of #senescent & #proliferative cell behaviors; this allocates distinct cellular tasks required for tissue repair, driven by mutual repression between JNK/AP-1 & JAK/STAT signaling @classenlab #PLOSBiology plos.io/43dDU1z
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Unveiling Paracrine Organizers in action! Discover how chronic wounds and tumors balance senescent & proliferative responses by avoiding coexistence of JNK/AP-1 & JAK/STAT signaling in Drosophila. Read our latest work for insights into spatial organization.doi.org/10.1371/journal.pbio…
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Bertie Göttgens, hematologist & stem cell researcher at @Cambridge_Uni, joins our Lecture Series: From early blood development to quantitative tissue models 📅Thursday, May 25th, 2023, 1pm 🚩@mpi_ie Lecture Hall Thanks to @MCRomeroMulero, IMPRS-IEM & @RTG_MeInBio for organizing.
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Thank you @yosoyden and Vincent Mirouse for highlighting our manuscript in @Dev_journal 🪰
Development@Dev_journal25 Apr 2023
In preprints: get to know your neighbours – cell interface surveillance through a molecular zip code @yosoyden & Vincent Mirouse highlight a #preprint identifying signalling receptors involved in sensing aberrant cells in the developing Drosophila wing: tinyurl.com/mwe7u89d
In preprints: a new preprint curation initiative from Development

ALT In preprints: a new preprint curation initiative from Development

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Vincent Mirouse @GReD_Clermont and I wrote about an awesome preprint by @classenlab: In preprints: get to know your neighbours – cell interface surveillance through a molecular zip code This perspective also contributed to the Forest of Biologists!🌳 forest.biologists.com/landsc…
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Have you also been wondering how epithelial cells are able to detect a ‘suspicious’ cell in their midst? Follow the link to the whole story and the thread for a summary and a simplified version. 1/13 biorxiv.org/content/10.1101/… #devbio #tumor #axonguidance #cellcompetition #SFB850

A cell surface code mediates tissue-intrinsic defense against aberrant cells in epithelia

Tissue-intrinsic error-correction mechanisms allow epithelial cells to detect aberrant neighboring cells and cause their removal from the tissue. The molecular mechanisms which grant cells the...

biorxiv.org
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And in case you missed it: Before Christmas we published that different signalling signatures can drive S-phase acceleration during regeneration. #regeneration #drosophila #stresssignalling #cellcycle #sphase @BUnifr @UniFreiburg @CIBSS_UniFR doi.org/10.1371/journal.pgen…
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Excited to share our latest paper on "Interface Surveillance", a tissue intrinsic defense system against aberrant cells. elifesciences.org/articles/8… #drosophila #epithelia #tumor #mutations #cellfate #cellcompetition #SFB850 @CIBSS_UniFR @BUnifr @UniFreiburg
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Eya controls bilateral affinity at the germline-soma interface to generate self-organizing inter-lineage units that ensure oocyte maturation. @VanessaWeisste @classenlab nature.com/articles/s41467-0…

Eya-controlled affinity between cell lineages drives tissue self-organization during Drosophila...

Nature Communications - Oogenesis depends on close interaction between germ cells and the surrounding somatic niche. Here the authors demonstrate that Eya controls bilateral affinity at the...

nature.com
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Excited to share that our study on how cell-cell affinity between two cell lineages locally controls cell shapes and globally drives self-organization of an entire tissue is out now in @NatureComms. #selforganization #morphogenesis #oogenesis #Drosophila nature.com/articles/s41467-0…
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Check out our new preprint, where we demonstrate that differential affinity between cell lineages is sufficient to drive the complex assembly of inter-lineage functional units and underlies tissue self-organization in Drosophila oogenesis. doi.org/10.1101/2022.07.28.5…
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We were asked to produce a short video of our lab for the faculty day. This is it and this is us: the Classenlab! 😀 @UniFreiburg @BUnifr – at Freiburg im Breisgau, Germany
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1/6 Interested in how abnormal cells are eliminated from tissues? Check out our new preprint on how JNK signalling at interfaces between two cell populations drives elimination, and how this surveillance system is evaded by oncogenic RasV12 clones: biorxiv.org/cgi/content/shor…
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Hey FlyFriends🙂 Happy to join #Dros22. If you are interested in spatial signaling during regeneration check out poster Nr 405V by @JanV_Jaiswal. And come see talk Nr 173 by @VanessaWeisste on how germline and soma control their interaction with each other to drive oogenesis.
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Scientists for Future! Classenlab goes climate strike along with 12000 other protestors in Freiburg! #Scientists4Future @F4F_Freiburg #FridayForFuture #AllesfuersKlima #Klimastreik #ClimateStrike
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