Gerone Gonzales retweeted
We've been studying mechanisms of resilience that protect lysosomes from damage and wrote a review on the topic. We consider lysosomal stress and damage on a spectrum; hopefully a useful concept😀. Snapshot below and Open Access here: embopress.org/doi/full/10.10…
Gerone Gonzales retweeted
Research from Dr. Jonathan Canton and his team sheds light on how specialized immune cells act as sentinels, providing a critical defense against infections. ucalgary.ca/news/ucalgary-re…
#Immunology #PublicHealth
@UCalgary @UCalgaryMed @ucalgaryvetmed @CantonJohnathan @GeroneGon
Gerone Gonzales retweeted
A new Science #Immunology study describes how #APOL7C recruitment to phagosome membranes in conventional #DendriticCells promotes antigen release to the cytosol and cross-presentation. @ucalgaryvetmed @UCalgary
bit.ly/3CjeKWp
Gerone Gonzales retweeted
New research in Science #Immunology identifies the pore-forming protein #APOL7C as a driver of phagosomal rupture and antigen cross-presentation in activated dendritic cells. @CantonJohnathan @GeroneGon @Liam_Wilki @_Cassie_Wood
bit.ly/3CjeKWp
Very happy to share the latest work from the @CantonJohnathan lab at @UCalgary , out in @SciImmunology investigating how APOL7C leads to antigen escape in the phagosome-to-cytosol pathway of cross presentation in cDCs! (1/11)
science.org/doi/10.1126/scie…
Our results show that APOL7C operates in the endocytic pathway of cDCs. Its NADPH oxidase-dependent recruitment to phagosomes results in phagosomal rupture and antigen leakage to the cytosol, leading to cross-presentation. (10/11)
We thank all the @CantonJohnathan lab members @Liam_Wilki, @_Cassie_Wood @CedEymi, our collaborators, editor @ClaireOlingy and funders!!
Find the paper here:
science.org/doi/10.1126/scie…
(11/11)
Gerone Gonzales retweeted
Excited to share that our story on apolipoprotein control of cross-presentation is now published in @SciImmunology and can be found here
science.org/doi/10.1126/scii…
Congrats first authors @GeroneGon , @Liam_Wilki and Song Huang, as well as @_Cassie_Wood and xless authors too. 😊
