Age ≥75 years predicts poorer survival but not higher complication rates after curative gallbladder cancer resection ➡️doi.org/10.1093/bjsopen/zrag… The prognostic influence of age on outcomes after gallbladder cancer (GBC) resection has been poorly characterised relative to other hepatopancreatobiliary malignancies. This international, multicentre retrospective cohort study analysed 3676 patients undergoing curative GBC resection across 133 centres in 41 countries (2010–2020), comparing outcomes in patients aged ≥75 years versus younger patients using propensity score matching. Older adults underwent less extensive surgery and lymphadenectomy and received adjuvant chemotherapy less frequently, and age ≥75 years was independently associated with poorer overall survival in both unmatched (HR 1.34) and matched (HR 1.31) cohorts, while recurrence-free survival and postoperative complication rates did not differ significantly by age group. The authors conclude that fitness rather than chronological age alone should guide eligibility for curative treatment, including major resection and adjuvant chemotherapy. 👏👏👏@HPBCambridge, Petros Barmpounakis, Nikolaos Demiris, Bodil Andersson, Alejandro Brañes, Xavier de Aretxabala, Paul Gibbs, Simon J F Harper, Emmanuel L Huguet, Asif Jah, Vasilis Kosmoliaptsis, Javier Lendoire, Siong S Liau, Shishir K Maithel, Jack L Martin, Colin Noel, Raaj K Praseedom, Alejandro Serrablo, Volkan Adsay, on behalf of the OMEGA Study Investigators #SoMe4Surgery #MedTwitter #SurgEd #Surgery @BJSAcademy @BJSurgery #HPBSurgery #SurgicalOncology #GeriatricSurgery #CancerSurgery

The OMEGA Study website is now live! Our international collaborative spans 133 centres across 41 countries , building the evidence base for gallbladder cancer surgery. Explore our research, online risk calculators and collaborator list: omegagallbladdercancerstudy.… #GallbladderCancer

Post-hepatectomy liver failure ➡️ doi.org/10.1093/bjs/znag004 🫀 PHLF remains the Achilles’ heel of liver surgery, with high mortality once severe liver failure develops 📊 Risk depends on functional liver remnant, liver quality, extent of resection, and postoperative complications 🔍 No reliable treatment exists, making preoperative assessment and prevention essential 📈 Volumetry, functional testing, and liver augmentation strategies are key before high-risk major hepatectomy Work by @ksoreide, Anita Balakrishnan , Helena Taflin #SoMe4Surgery #MedTwitter #SurgEd #Surgery @RCPSGTrainees @aecirujanos @SEIQuirurgica @iss_sic #MedicalTechniques @BJSAcademy @young_bjs @BJSOpen @evanscolorectal @robhinchliffe1 @bplwijn @MalinASund @nfmkok @TejedorPat @paulo_sutt @PVaughanShaw @JJEarnshaw @juliomayol #some4hpb #some4tpl @DPCG_official @pancreatitis_nl @PancreasClub #PancreasClub2023 #PancreaticCancer #Pancreatitis #HCC @PanCAN #PanCANawareness @EurPancClub @P_C_E_ @dice_europe #PancreaticCancer #cholangiocarcinoma #HPBSurgery #GallbladderCancer #Oncology #LiverSurgery