@HalbergLab

Using flies and beetles to study interorgan communication and neuropeptide signalling in maintaining internal homeostasis

 Copenhagen, Denmark
www1.bio.ku.dk/cnb/research/the-neuroendocrinology-and-physiology-group/
Joined September 2013
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  • Following78
  • Followers195
4Media
What can insects teach us about hormones and physiology? In our new @APSPhysiology review, we highlight how insect models continue to unlock fundamental insights into endocrine signaling and interorgan communication. Thx to my co-authors & @LabRewitz! journals.physiology.org/doi/…
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🪰🆕@physiol_journal! This review highlights key insights into hormonal control of growth, behavior, and metabolism, revealing fundamental mechanisms of animal adaptation. Takashi Koyama, et al. ➡️ ow.ly/MBfy50Vlm3Z @HalbergLab #hormones #physiology #insertmodels
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🪰Monday must read! This review highlights key insights into hormonal control of growth, behavior, and metabolism, revealing fundamental mechanisms of animal adaptation. Takashi Koyama, et al. ➡️ ow.ly/uqib50VllYo @HalbergLab #hormones #physiology #insertmodels
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This week, we are also highlighting Vincent Wigglesworth as an extraordinary biologist. Vincent was the fourth Editor-in-Chief of @J_Exp_Biol and also published in @Dev_journal and @J_Cell_Sci #100biologists
The Company of Biologists 100 logo to the left and QR code to the right. Portrait of Vincent Wigglesworth to the left, text to the right 100 extraordinary biologists Vincent Wigglesworth Sir Vincent Wigglesworth was the fourth JEB Editor-in-Chief. Wigglesworth indulged his passion for insect physiology by studying disease-bearing species while a lecturer at LSHTM. After joining the University of Cambridge, Wigglesworth studied the physiology of insects, including Rhodnius prolixus. #100biologists #biologists100

ALT The Company of Biologists 100 logo to the left and QR code to the right. Portrait of Vincent Wigglesworth to the left, text to the right 100 extraordinary biologists Vincent Wigglesworth Sir Vincent Wigglesworth was the fourth JEB Editor-in-Chief. Wigglesworth indulged his passion for insect physiology by studying disease-bearing species while a lecturer at LSHTM. After joining the University of Cambridge, Wigglesworth studied the physiology of insects, including Rhodnius prolixus. #100biologists #biologists100

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PhD position in @DenholmLab ' Exploring form & function in one of nature’s most powerful water-conservation systems' working on insect renal system development, physiology and evolution. findaphd.com/phds/project/ea… apply by 17th January 2025. Please repost

EASTBIO Exploring form & function in one of nature’s most powerful water-conservation systems at...

PhD Project - EASTBIO Exploring form & function in one of nature’s most powerful water-conservation systems at University of Edinburgh, listed on FindAPhD.com

findaphd.com
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HalbergLab retweeted
RewitzLab@LabRewitz26 Sep 2024
We are thrilled to share that @eLife has now published our "reviewed preprint" on how signaling from the gut to glia connects intestinal inflammation to sleep in #Drosophila! elifesciences.org/reviewed-p… @HalbergLab @Colombani_lab @lundbeckfonden @novonordiskfond @Carlsbergfondet
RewitzLab@LabRewitz10 Jul 2024
We are excited to share our recent work on gut-to-glia communication linking intestinal inflammation with sleep in #Drosophila! Many thanks to @HalbergLab and Andersen and @Colombani_lab! @lundbeckfonden @novonordiskfond @Carlsbergfondet @UCPH_Research biorxiv.org/content/10.1101/…
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HalbergLab retweeted
RewitzLab@LabRewitz22 Jul 2024
Thrilled to share our work! Thanks to @NovoNordiskFond and @DFF_raad, we unveil how LGR signaling mediates crosstalk between muscle, neuronal, and adipose tissues, protecting against #insulinresistance and offering insights into #Diabetes and #Obesity. nature.com/articles/s41467-0…

LGR signaling mediates muscle-adipose tissue crosstalk and protects against diet-induced insulin...

Nature Communications - Obesity induces insulin resistance and impairs insulin signaling, causing diabetes. Here, the authors show that BMP and LGR signaling mediate communication between muscle,...

nature.com
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HalbergLab retweeted
RewitzLab@LabRewitz10 Jul 2024
We are excited to share our recent work on gut-to-glia communication linking intestinal inflammation with sleep in #Drosophila! Many thanks to @HalbergLab and Andersen and @Colombani_lab! @lundbeckfonden @novonordiskfond @Carlsbergfondet @UCPH_Research biorxiv.org/content/10.1101/…
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Happy to share our latest paper from the lab: “BeetleAtlas: An Ontogenetic and Tissue-specific Transcriptomic Atlas of the Red Flour Beetle Tribolium castaneum” out now in @JmolBiol. Thx for generous funding by @VILLUMFONDEN @DFF_raad sciencedirect.com/science/ar…
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In this paper we document the utility of this new transcriptomic resource, BeetleAtlas.org, which we belive has the potential to be transformative to both the Tribolium and general insect communities. Try it out and let us know your feedback!
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The latest on the beetle cryptonephridial complex from our collaboration between @DenholmLab and @HalbergLab doi.org/10.1101/2024.03.01.5…
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New paper 🚨 from the lab in collaboration with @JPPaluzzi lab. Postdoc @gera_jayati's first project from the lab on the discovery of the receptor for the fly anti-diuretic hormone, ITP. Check out the 🧵for more info (1/n) biorxiv.org/content/10.1101/…

Anti-diuretic hormone ITP signals via a guanylate cyclase receptor to modulate systemic homeostasis...

Insects have evolved a variety of neurohormones that enable them to maintain their nutrient and osmotic homeostasis. While the identities and functions of various insect metabolic and diuretic...

biorxiv.org
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Latest from the lab: What are the mechanism by which insects maintain systemic ion and water balance as they interact with their environment? Another great collaboration with @DenholmLab!annualreviews.org/eprint/FXM…
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Replying to @anthony_dornan
@anthony_dornan @HalbergLab @tubuleguy and colleagues find that age-dependent decline in renal function is associated with compromised barrier integrity, which is phenocopied by acute loss of Snakeskin. Highlight: journals.biologists.com/jcs/… Article: journals.biologists.com/jcs/…
Images showing that Ssk depletion promotes failure of the junctional complex, resulting in loss of cellular cytoarchitecture and apicobasal polarity.

ALT Images showing that Ssk depletion promotes failure of the junctional complex, resulting in loss of cellular cytoarchitecture and apicobasal polarity.

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Our paper with JCS cover out now! - In Drosophila age-related decreased kidney function, due to loss of epithelial barrier integrity and failure of fluid homeostasis, phenocopied by cell-specific knockdown of the essential junctional protein Snakeskin. journals.biologists.com/jcs/…
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The paper is featured in JCS 'Research Highlights' as, embarrassingly, I am in the First Person 'Interview'. journals.biologists.com/jcs/…. It's been a struggle to get this work out but - Paper/Cover/Highlights - I can't be prouder. @HalbergLab @tubuleguy
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Really excited to share the lab's first Drosophila paper and it's a big one. Check out our preprint shorturl.at/gqrvO where we present the complete neural connectome of an animal circadian clock. 🧵 (1/12)
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HalbergLab retweeted
RewitzLab@LabRewitz17 Aug 2023
Our preprint on #Obesity-driven #InsulinResistance reveals a muscle-neuronal-fat axis adapting to high-sugar-induced obesity conditions by influencing insulin secretion & sensitivity in #Drosophila. @Halberglab biorxiv.org/content/10.1101/…

A neuronal relay mediates muscle-adipose communication that drives systemic metabolic adaptation to...

Obesity leads to impaired insulin signaling and tissue sensitivity, which drive the onset of type 2 diabetes. Insulin resistance leads to a reduction in cellular glucose uptake, resulting in elevated...

biorxiv.org
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Our last review: Drosophila TNF/TNFRs: At the crossroad between metabolism, immunity, and tissue homeostasis J. Colombani & D.S. Andersen - FEBS Letters - Wiley Online Library febs.onlinelibrary.wiley.com…

FEBS Press

In this review, we summarize the recent advances in our understanding of how local and systemic sources of TNF contribute to its antitumor and tumor-promoting properties. The recent annotation of...

febs.onlinelibrary.wiley.com
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Curious about how some beetles have evolved to drink, not with their mouths, but with their rectum? Check out our latest Quick Guide in the current issue of @CurrentBiology. In collaboration with @RobinBeaven @DenholmLab sciencedirect.com/science/ar…
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