Tuebingen, Germany
Joined June 2020
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1/4 Very happy to share the short history about how we discovered a natural #degron of #cereblon @BBRCME.
We show how #CRBN specifically recognizes C-terminal cyclic imides as protein damage markers.
Shout-out to Chris @NanoTemper & the Schwarzer group!
sciencedirect.com/science/ar…
Marcus Hartmann retweeted
Pleased to share our collaborative effort to develop anti-virulence agents. We unveiled a series of compounds targeting the transcriptional regulator HilD. Feedback is welcome!
Discovery of a synthetic small molecule targeting the central regulator of Salmonella pathogenicity biorxiv.org/cgi/content/shor… #biorxiv_micrbio
Marcus Hartmann retweeted
We just released the "protein design toolkit", integrating tools from Damietta, ProteinMPNN and OpenMM.
An interactive tutorial is available at the server damietta.de. Recommended usage is described in the paper: doi.org/10.1093/nar/gkae297 and feedback is most welcome!
Marcus Hartmann retweeted
😁🎉😄🌟#NobelPrize!🙃🙃🙃🙃🙃🙃🙃🙃🙃🙃🙃😊🏆😁#PhysicsNobelPrize2023 for Ferenc Krausz, Max Planck Institute of Quantum Optics! 🎊😃🥰😆🥳😁😃🎉🏅😊🎈😁🥳😄🎊😁🌟😃🥰🏆😁🎉🎇😊🥳😄🌟🎈😁😃🥰🎉🏆😁🎊😊😄🥳🌟🎇😁🥰😃🎉🎈😁🏆😊😄🎊🥳😁🌟😃🥰🎉🏅😁🎈😊🥳😄🎉😁😍😁🎉🎇😊🥳😄🌟🎈🏆
Sleeves up for infection research:
Our postdoc Joe Joiner researches anti-infectives to prevent #Salmonella infection. He’s not only appreciated as a talented researcher, but also as a great teacher by his students!
@PAW_Germany #PostDocAppreciationWeek @MPI_Bio
Marcus Hartmann retweeted
A press release about our recent paper in @PNASNews
pnas.org/doi/10.1073/pnas.22…
Cyanobacterial protein integrates the circadian clock information
growkudos.com/publications/1… via @growkudos @uni_tue_exstra @CoE_CMFI @MPI_Bio
Marcus Hartmann retweeted
Fun fact: At 1.06 Å, this is the first-ever structure of any histone protein determined at atomic resolution - for what it's worth! 🤣
doi.org/10.1101/2023.02.26.5…
Marcus Hartmann retweeted
Congrats, truly seminal work! Since our initial discovery of bacterial histones, we too worked on the very same histone protein & now present its crystal structure & DNA-binding properties. Great work by Yimin, Birte & collaborators @HartmannLab @MPI_Bio
doi.org/10.1101/2023.02.26.5…
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Marcus Hartmann retweeted
An excellent perspective by authors from @AstraZeneca about fragment-based approaches to identify ligands for E3 ligases. Of especially high relevance for the field of targeted protein degradation (#TPD). @ACSBioMed pubs.acs.org/doi/10.1021/acs…
Check out our work on regulating #Salmonella virulence @biorxivpreprint!
Great job by Joe, Wieland, Thales, @BangeBalcony, @atposo & @samuwag:
HilE represses the activity of HilD via a mechanism distinct from that of intestinal long-chain fatty acids. biorxiv.org/content/10.1101/…
Marcus Hartmann retweeted
After long time in oven, happy to share w/ @HartmannLab @PNASNews
our work #Cyanobacteria #Carbon #Sensor SbtB possesses atypical #Redox regulated #Apyrase (hydrolysing ATP/ADP) to control HCO3 transport
Generous fund by @uni_tue_exstra @CoE_CMFI @MPI_Bio
pnas.org/doi/10.1073/pnas.22…
Marcus Hartmann retweeted
Synthesis of novel glutarimide ligands for the E3 ligase substrate receptor Cereblon (CRBN): Investigation of their binding mode and antiproliferative effects against myeloma cell lines sciencedirect.com/science/ar…
🥳🥳 Congrats, great job! 🥳🥳
Fantastic PhD defense by Joe this week, showcasing great results from your collaborative salmonella anti-virulence project with @samuwag @atposo @BronstrupLab!
#Salmonella, beware of Joe! @phd_reps_MPI_DB
We couldn't agree more - this is a fascinating topic and we are more than happy to provide the structural basis for the recognition of the C-terminal cyclic imide #degron in our new communication @BBRCME:
sciencedirect.com/science/ar…
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3/4 Strinkingly, the aspartimide degron recognition mode is exactly the same as the one we previously identified for aspartimide based #CELMoDs / #IMiDs @ACSBioMed:
pubs.acs.org/doi/10.1021/acs…
4/4 We are more than happy to finally reveal the structural basis 2 years after Chris defended his thesis & finally want to congratulate @drcmwoo, her team & collaborators for their fantastic & very thorough chemical biology work on the same topic @Nature!
#PROTACs #Thalidomide
Marcus Hartmann retweeted
Speechless! HAPPY! Pinching ourselves! #NobelPrize2022 in Physiology or Medicine😁🥳😃🙃🤗😊🤗🙃🥳😃😁😀 🥳😃😁😀🙃🤗😊😆🤣😆Svante Pääbo @MPI_EVA_Leipzig 😆😊🤗@maxplanckpress 🙃😀😁😃🥳😃😀🙃🤗😊🤣😆🤣😊😊🤗🤗🙃🥳😀😆🤗😊🙃🥳😃😀😆😊🤗🙃🙂😄😲😀😁😃🥳🙃🤗😊🤗🙃🥳😃😁😀😲🥳😊 🥳