@ImmunoKevin

MD PhD student at UMass Chan MSTP, studying nucleic acid sensing and immunology, aspiring pediatrician and physician-scientist

 Worcester, MA
scholar.google.com/citations?hl=en&user=K8qbN4EAAAAJ
Joined September 2019
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You can read our new study, out now in @JCI_Insight! (tinyurl.com/4bjcraeu) We examine how expression of a STING gain-of-function (GOF) mutation in radioresistant host cells results in the development of lymphocyte autoimmunity. Some highlights from our study: (1/7)
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Ivan Zanoni
@Lo_Zanzi16 Oct 2024
#InterferonsFriendsOrFoes?! @labs_mann @NordmannThierry French Ji &co using single cell proteomics identify @Nature an IFN signature in macrophages & keratinocytes KCs in a fatal #skin disease showing that JAK inhibition prevents KC death, curing patients nature.com/articles/s41586-0…

Spatial proteomics identifies JAKi as treatment for a lethal skin disease

Nature - Cell-type-resolved spatial proteomics of the skin from patients with toxic epidermal necrolysis reveals that it is driven by JAK/STAT signaling, leading to successful treatment of this...

nature.com
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Mingqi Dong@Mingqi7up4 Oct 2024
nature.com/articles/s41590-0… I hope this is a helpful review! Appreciate the opportunity to co-write this review in @NatImmunol with my mentor @FitzgeraldKate. Thanks to all the reviewers' comments which significantly elevated our work and thanks to the unsung artists for their art!
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Casanova Lab@casanova_lab25 Sep 2024
1/ We are excited to share a simple yet powerful whole blood assay to detect human type I interferon (IFN) deficiency...
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bioRxiv Immunology@biorxiv_immuno14 Sep 2024
Longitudinal Multi-omic Immune Profiling Reveals Age-Related Immune Cell Dynamics in Healthy Adults biorxiv.org/cgi/content/shor… #biorxiv_immuno
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JCI insight
@JCI_insight5 Sep 2024
An autoinflammatory syndrome-associated STING mutation supports formation of germinal centers containing immunocompetent cells in the lungs of irradiated mice following BMT- insight.jci.org/articles/vie… Study from@ImmunoKevin and colleagues @kchianggg @FitzgeraldKate @UMassChanPII
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Waggoner Lab@LabWaggoner27 Aug 2024
Innate immune responses against mRNA vaccine promote cellular immunity through IFN-β at the injection site nature.com/articles/s41467-0…
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Cell Reports@CellReports27 Aug 2024
An evolutionary perspective to innate antiviral immunity in animals dlvr.it/TCRyJD
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Sandro Alessandrini@SandroAlessa1722 Aug 2024
Our paper introducing the concept of 'defensive tolerance' officially came out in @jclinicalinvest. I would like to thank all our collaborators, as well as Drs. Molinari and Cravedi for their wonderful accompanying commentary. #defensivetolerance jci.org/articles/view/179709
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I also want to acknowledge Dr. Kerstin Nundel, who not only contributed to this study but has also been a constant and amazing mentor throughout my PhD training. Thank you also to our collaborators, Dr. PJ Utz and Xihui Yin for their generous help and support.
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Lastly, thank you to my thesis advisors Drs. @FitzgeraldKate and Ann Rothstein. Ecstatic to see this piece of my thesis work finally published.
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