Director of Scientific & Strategic Operations Department of Structural Biology St. Jude Children's Research Hospital @StJudeStructBio Opinions my own.
Joined December 2020
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Congrats @DanielS20127197, Brenda and all coauthors!
Out @MolecularCell from Schulman group @StJudeResearch & @MPI_Biochem: E3 Ub ligase CRL2-KHLDC2 uses a kinetic mechanism and auto-inhibitory self-assembly to avoid targeting non-substrate proteins with degron-like sequence.
authors.elsevier.com/a/1gbyX…
Inês Chen retweeted
Work from @LabHalic with @StefanCanzar now @NAR_Open.
Using genome-wide approaches to dissect the pathways that lead to #heterochromatin silencing, they unveil a new mechanism — decreased transcription efficiency, in a pathway that requires CCR4–NOT.
academic.oup.com/nar/advance…
Congrats @TheCHLeeLab and all coauthors!
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Very excited to see everyone next week!
We look forward to welcoming our guest speakers in person at St. Jude next Monday for the Symposium!
#structuralbiology #crystallography #NMR #cryoEM #cryoET #MDSims #HybridMethods #MachineLearning #ComputationalStructuralBiology #IntegrativeStructuralBiology
Congrats to Maximiliane Wieland @ERundlet @MikaelScience and all coauthors!
Work from @TheBlanchardLab and @WilsonLab2 combines #smFRET and #cryoEM to reveal the mechanism of action of antimicrobial peptide argyrin: ArgB binds EF-G on ribosome and inhibits conformational changes required for translocation and EF-G dissociation.
pnas.org/doi/full/10.1073/pn…
Inês Chen retweeted
Our new manuscript on LRRK2 activation with @zhu_hanwen Francesca and Dario @ASAP @LRRK2_central. We reveal a novel LRRK2 kinase activation mechanism via spatial regulation and protein non-symmetric tetramerization (dimer of asymmetric dimers). See animation (credit @NormanLuo5)
Inês Chen retweeted
New work from @TheBlanchardLab and the Javitch group reveals new insights into beta-arrestin activation and interaction with GPCR, using the power of #smFRET, now out @CellCellPress, congratulations!
Check out the work here:
cell.com/cell/fulltext/S0092…
Congrats Anne, @BorcherdsWade and all coauthors!
Now out @NatureChemistry: work from @TanjaMittag lab in collaboration with @PappulabWashU deciphers the rules in the stickers-and-spacers model that govern phase separation by prion-like low-complexity domains.
nature.com/articles/s41557-0…
Congrats to @Kriwacki and @CMullighan labs!
Out in @CD_AACR: by integrating biophysics, cellular imaging and transcriptomics, Kriwacki, Mullighan & colleagues demonstrate the role of LLPS in leukemogenesis by NUP98 fusion oncoproteins and identify the specific molecular interactions involved.
cancerdiscovery.aacrjournals…
pretty cool story, using MAS ssNMR and MD sims!
Hi-res ssNMR illuminates structures of antifungal AmB “sponges” consisting of asymmetric head-to-tail homodimers staggered in a clathrate-like lattice with large void volumes similar to the size of sterols. @TarasPogorelov @nmrfam @Illinois_Alma @UWMadison nature.com/articles/s41594-0…
Whoa, the entire Uniprot...
🤯
Today with @emblebi we’re expanding the #AlphaFold Protein Structure Database to cover UniProtKB/Swiss-Prot (of @uniprot). This includes key proteins of interest that have been manually curated by experts & will more than double the database size to >800k! dpmd.ai/alphafolddb
More sodium-solute symporters @Nature, now from Lei Chen @PKU1898: #cryoEM structure of human SGLT2 in complex with auxiliary membrane protein MAP17 and inhibitor empagliflozin (used to treat type 2 diabetes).
nature.com/articles/s41586-0…
From Feng lab @StanfordMed and @LabSkiniotis:
#cryoEM of 2 human Na+/solute symporters —
SGLT1 (Na+/glucose, apo) and SMCT1 (Na+/monocarboxylates, with substrate) —
provide a trove of functional insights on these important transporters. Out in @nature
nature.com/articles/s41586-0…
Amazing work, congrats!!
Worth highlighting: the structure of the TDP-43 filament core is very different from those of filaments formed in vitro.
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Inês Chen retweeted
Looking back at an exciting year: In this month’s editorial, we highlight some of our favorite research of 2021, including Covid-19 treatments, Nobel prizes, AlphaFold and more. Check it out here: nature.com/articles/s41594-0…
Nature is looking for an editor with expertise in biochemistry, molecular biology and/or structural biology. Check it out, it closes on Dec 15!
nature.com/naturecareers/job…
Inês Chen retweeted
An Analysis presents the results of a community evaluation of existing software for large-scale mass spectrometry-based glycopeptide data analysis.
@KawaharaSRebeca @mtandersen_lab @hupo_org #glycotime
OA paper: nature.com/articles/s41592-0…
👏 congrats!
We used #cryoEM to identify the proteins that form mammalian doublet microtubules in bovine respiratory cilia and contribute to the motility of cilia @miao_gui @jacobranderso @JosephineBotsch sciencedirect.com/science/ar…
Inês Chen retweeted
Join us! St. Jude is recruiting multiple research faculty at the full, associate, and assistant levels in a major expansion of our basic and translational research programs. #cancerresearch #facultyjobs @stjuderesearch stjude.org/cancer-center-fac…
