Isabel Werle (@Isabeus_) header
Isabel Werle (@Isabeus_) profile picture

Isabel Werle

@Isabeus_

Psychopharmacology PhD student at @bertogliolab :)

 Florianópolis
researchgate.net/profile/Isabel-Werle-3
Joined December 2012
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Photo by Isabel Werle (@Isabeus_)Photo by Isabel Werle (@Isabeus_)Photo by Isabel Werle (@Isabeus_)Photo by Isabel Werle (@Isabeus_)Photo by Isabel Werle (@Isabeus_)Photo by Isabel Werle (@Isabeus_)Photo by Isabel Werle (@Isabeus_)Photo by Isabel Werle (@Isabeus_)Photo by Isabel Werle (@Isabeus_)Photo by Isabel Werle (@Isabeus_)
🆕Excited to share our latest review on psychedelics and fear extinction @Isabeus_ @FarmacoUFSC @fapesc @UFSC journals.sagepub.com/doi/10.…
Where is the sweet spot for psychedelic-enhanced fear extinction? An integrative quantitative...

Where is the sweet spot for psychedelic-enhanced fear extinction? An integrative quantitative...

Background: Individuals with anxiety and stress-related disorders frequently demonstrate impaired threat extinction. Although psilocybin, lysergic acid diethyla...

journals.sagepub.com
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Replying to @PsyPost
@PsyPost We greatly appreciate the dissemination of our most recent work on ayahuasca (DMT) as a fear extinction facilitator @Isabeus_ @FarmacoUFSC psypost.org/scientists-ident…
Scientists identify key brain mechanism behind ayahuasca's ability to reduce PTSD symptoms

Scientists identify key brain mechanism behind ayahuasca's ability to reduce PTSD symptoms

A study in European Neuropsychopharmacology finds that ayahuasca helps rats learn that a previously dangerous environment is safe. This effect appears to rely on BDNF signaling within the infralimbic...

psypost.org
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Como a ayahuasca ajuda a extinguir memórias aversivas? Neste infográfico resumimos os resultados de nosso artigo científico mais recente. Abaixo, o link temporário para acesso gratuito ao PDF desse trabalho. @Isabeus_ @FarmacoUFSC @UFSC #psychedelics authors.elsevier.com/a/1mHwf…
Image from Bertoglio lab (FMC/UFSC) (@bertogliolab)
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Excited to contribute to this piece on CBD effects on anxiety and fear memory, together with @MarinaPort68942, @Isabeus_, @LucianeAlfaia, @mest_prof_fmc, @FarmacoUFSC, and Fernanda Guterres revistafitos.far.fiocruz.br/…
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📢Paper alert! Check out our perspective on #psychedelics and sports, exploring potential benefits, risks, and open questions. @scnpjournal, @MarinaPort68942, @Isabeus_ doi.org/10.1017/neu.2025.13
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Check out our new paper in which we review what is currently known on how psychedelics acutely and post-acutely modulate fear conditioning, extinction learning, episodic memory, and semantic memory and how such effects may speak to treatment of PTSD. link.springer.com/article/10… 1/8
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🌟Review Alert! Excited to share our latest article, where we explore the effects of serotonergic #psychedelics and related substances (e.g., MDMA) on extinguishing and reconsolidating aversive memories, expressing fear/anxiety, and locomotion in rodents. authors.elsevier.com/a/1jq5G…
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Congratulations to @Isabeus_ and Aymee for winning the Poster Presentation Awards at the @SBFTEnet Congress! @FarmacoUFSC and Bertoglio lab are proud of your outstanding contributions to research on fear extinction and psychedelics!
Image from Bertoglio lab (FMC/UFSC) (@bertogliolab)
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#CBD Thrilled to see our book chapter on cannabidiol's effects on fear processing & PTSD published online! Thanks @FrancescaLisboa, @CristinaStern, and @Lgazarini doi.org/10.1016/bs.irn.2024.…
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🥇Isabel Werle @Isabeus_ , doutoranda no @bertogliolab, conquistou o prêmio de melhor pôster no Congresso da IBNS@IBNSconnect na categoria pós-graduando. Parabéns por mais essa conquista, Isabel! Agradecimentos à @IBROorg, @farmacoufsc, @ufsc e @CNPq_Oficial pelo apoio!
Image from Bertoglio lab (FMC/UFSC) (@bertogliolab)
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We need robust behavioral assays for #psychedelic drug development. In this new study, @Sam_C_Woodburn systematically determined psilocybin’s effect on fear extinction as a function of dose, timing of administration, and serotonin receptors 🍄🐁 biorxiv.org/content/10.1101/…
Psilocybin facilitates fear extinction: importance of dose, context, and serotonin receptors

Psilocybin facilitates fear extinction: importance of dose, context, and serotonin receptors

A variety of classic psychedelics and MDMA have been shown to enhance fear extinction in rodent models. This has translational significance because a standard treatment for posttraumatic stress...

biorxiv.org
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Very pleased to see this work officially published! More results coming, isn't that right, @Isabeus_ 😉! bpspubs.onlinelibrary.wiley.…
BPS Publications

BPS Publications

Background and Purpose Ayahuasca (AYA) is a botanical psychedelic with promising results in observational and small clinical trials for depression, trauma and drug use disorders. Its psychoactive...

bpspubs.onlinelibrary.wiley.com
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Temos uma bolsa de iniciação científica PIBIC/CNPq (R$ 700/mês) pra trabalho remoto na análise dos dados da Iniciativa Brasileira de Reprodutibilidade. A vaga é aberta para alunos de graduação em qualquer lugar do país. Detalhes e inscrições até 26/1 em forms.gle/D8zess8XXZ1WTWfN9
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Discovery of a CB2 and 5-HT1A receptor dual agonist for the treatment of depression and anxiety sciencedirect.com/science/ar…
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Identification of 5-HT2A receptor signaling pathways associated with psychedelic potential nature.com/articles/s41467-0…
Identification of 5-HT2A receptor signaling pathways associated with psychedelic potential

Identification of 5-HT2A receptor signaling pathways associated with psychedelic potential

Nature Communications - Serotonin 5-HT2A receptor signaling mechanisms associated with predicting psychedelic potential remain elusive. Using 5-HT2A-selective β-arrestin-biased ligands, here...

nature.com
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Congrats to @Isabeus_ for poster honorable mention at SBFTE Congress
Image from Bertoglio lab (FMC/UFSC) (@bertogliolab)
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Isabel Werle retweeted
Sam Woolfe (@samwoolfe) profile picture
Sam Woolfe@samwoolfe7 Jun 2023
Here I explore bad trips caused by combining #psychedelics w/ #cannabis. One study found, however, that this combo has potential rewards: greater mystical & ego-dissolution effects. It also found that low doses of cannabis reduce the chances of a bad trip. chemical-collective.com/the-…
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nature.com/articles/s41583-0…

The plasticitome of cortical interneurons

Nature Reviews Neuroscience - Cortical inhibitory interneurons undergo diverse forms of long-term synaptic plasticity. In this Review, Sjöström and colleagues describe the diversity of...

nature.com
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Science ran a big experiment on itself for the last ~60 years. It didn't work out. experimentalhistory.substack…
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Isabel Werle retweeted
Dr Meming (@Dr_Meming) profile picture
Dr Meming@Dr_Meming28 Aug 2022
The amount of experiments I do vs the the results
Image from Dr Meming (@Dr_Meming)
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