Reimagining what personalized rehab can produce. Teaching people why they hurt, then rebuilding from there.
Columbus, Ohio
Joined July 2022
- Tweets1.2K
- Following3.6K
- Followers378
- Likes6.7K
Jacob Coffman retweeted
5 years of this at full production would mean SpaceX produces as much electricity in orbit as the entire US electrical grid.
We have signed a major supply contract with SINGULUS to create a durable option for advanced solar cell manufacturing to support more than 100 GW of equipment as we accelerate the production of our Starmind satellites in Bastrop, Texas ā singulus.com/2026/11/10/spacā¦
Jacob Coffman retweeted
No other traveler has ever journeyed so far from home.
Voyager 1 is about to become the first human-made object to reach a distance of one light-day from Earth, or about 16 billion miles. Ā½
Jacob Coffman retweeted
I have stage 4 cancer. I thought I'd fight it alone.
I was wrong.
Since mid October, ~20 strangers on X have stepped up to help me. All for free so far:
- An NYU Langone lab offered to run my tumor data through their system to sharpen my vaccine targets
- A U Michigan lab offered to test drugs on my actual tumor cells
- A biotech ran AI analysis on my tumor RNA
- A vaccine company offered to design a second vaccine to check the first one
Scientists. Engineers. People I've never met.
Cancer has been picking us off one at a time for all of human history. It counts on us fighting it alone, scared and quiet.
Not anymore.
We have AI. We have the internet. We have each other.
Cancer, we're coming for you, bitch. Buckle up!
Jacob Coffman retweeted
I think the data center backlash is the best thing to happen to AI. For years, cheap capital let builders ignore the communities and their neighbors. Now they must design for them. Quieter cooling, their own power, a share of the tax base. Show average-day Americans WHY they should trust this technology being built. This is a time of OPPORTUNITY.
Jacob Coffman retweeted
Memphis Mayor Paul Young confirming @elonmuskās statement that Memphis is booming because of the data centers:
āThis year was $54 million in taxes generated. Last year about $25 million ā it was the second-largest taxpaying property in Shelby County.ā
Jacob Coffman retweeted
It was a record nesting season for sea turtles on Boca Chica Beach!
@SeaTurtleInc protected 58 nests on Boca Chica from April to August, its biggest season ever there. Last year saw 16 nests all season. This year, 16 were found on June 7 alone.
This season's highlights:
54 Kemp's ridley, 3 green and 1 loggerhead nests
5,296 eggs protected
2,435 hatchlings released
64 sea turtle patients saved
8,735 miles patrolled over 669 hours
Thank you to their team for protecting these nests all season, to @SpaceX for supporting their work, and to everyone who helped keep nesting turtles and hatchlings safe on our beach. š¢
Jacob Coffman retweeted
āWe studied 1,600 data centers ... and we find that they create non-construction jobs.ā
An Ohio economics professor says data centers generate an estimated 1,000ā1,300 additional jobs within 3ā5 years of opening.
That's ON TOP of the jobs needed to build them.
Jacob Coffman retweeted
10 DAYS UNTIL VOYAGER 1 IS A FULL LIGHT-DAY AWAY FROM EARTH!!!
ALT An artistās impression of Voyager 1
Jacob Coffman retweeted
Across our projects @GoogleDeepMind, we are witnessing a genuine phase transition in the pace of scientific discovery. You will see a glimpse of this in our releases in the next few weeks.
Jacob Coffman retweeted
If they pull this off, it will change spaceflight forever. I expect them to pull it off.
Starship is preparing for catch
Flight 15 is targeting to launch as early as Friday, November 13, pending regulatory approval ā spacex.com/launches/starshipā¦
Jacob Coffman retweeted
Yesterday I posted about working with an AI scientist to find new ways to fight my cancer.
A chemistry professor at the University of Michigan saw it and emailed me. Matt Soellner @mbsoellner works on the exact kind of lung cancer I have. He offered to synthesize compounds and test them in cells and animals.
A lightbulb š” goes off above my head. Obviously...I MUST introduce Matt to Jan.
Andddd by this morning, they're talking about how to take an AI-designed molecule off a computer screen, make it in a lab, and find out whether it can fight my cancer.
EXCUSE ME!? Less than 24 hours after my post.
We haven't made a drug. We don't know whether any of this will work. Making and testing compounds will take months.
But Matt saw a patient trying to find a way forward and chose to help. He brought the ability to make and test things that might otherwise never leave a computer screen.
I'm sharing this as it happens because this is what gets me excited about AI. I can put my story out there, connect people with different skills, and help move an idea toward an actual experiment against cancer.
I deal with the every day bullshit from cancer as a patient but have realized there's an army of incredible people out there working hard behind the scenes on treatments and cures for people like me and millions of others.
It's an honor and a privilege to bring their efforts out for the world to see. AI is accelerating what these scientists can do. I'm just the human meat proxy making introductions and sharing the story.
But if that helps get a promising idea off a screen and into a lab faster, I'll take it! š„©
So get this...a stranger DM'd me on X and offered to help design my backup cancer drug. For free!
His name is Jan Domanski @jandom_random. He runs science at @open_fold, an open-source AI model that predicts how proteins and drugs physically fit together.
My cancer is driven by one broken protein called ALK. Lorlatinib (the daily pill I take) jams itself into it and shuts it down. It's working. But resistance isn't an if, it's a when. The tumor mutates the pocket and the drug stops fitting.
So Jan started modeling it on his own time, burning his own tokens. He ran AI models against ALK and lorlatinib, mapping where the known escape mutations land.
And what did he find? Most of them hit right in the drug's pocket, swapping small pieces for bigger ones that physically block the drug. That's the good kind of bad news. A pocket problem is something you can design around.
But the normal route to a new drug is ~2 years and ~$4-5M just to be ready for human testing. Jan's dream is getting a medicine to one patient in ~1 month.
I'm not taking a homemade molecule while lorlatinib works. But if it ever fails....shit...I've got a guy!
I started posting actively on X just a few weeks ago and it has brought me together with the most amazing, generous people!
Jacob Coffman retweeted
Today Physical Superintelligence PBC is announcing a proof of the Aaronson-Ambainis conjecture, one of the central open problems in quantum complexity, with major implications for quantum computing speedup.
psi.inc/research/aaronson-amā¦
Thread š
Jacob Coffman retweeted
This is a bigger deal than people might think! 100% process waste water recycling means ZERO liquid discharge.
Our waste water treatment facility is not just advanced but unique in automotive industry!
This is a key sustainability commitment to the region we are operating in!
Jacob Coffman retweeted
Greg Brockman:
"I think that youāre gonna see real delivery and real significant strides and impacts on biology, health, and curing of diseases over the next 12 months, 18 months."
I would take this timeline very seriously. Greg is quite clearly extrapolating from the capabilities of OpenAI's internal model.
"Navier-Stokes for drug discovery" is coming soon.
OpenAIās Greg Brockman says "death becoming a choice" is possible, and predicts AI will make real strides on curing diseases in the next 12 to 18 months
āI think that you look at something like biology, and thatās not something thatās unique to just humans. I think that we all suffer, that the question of even just thinking about death becoming a choice. All of this is possible.ā
āHaving cures for diseases is something thatās become also a trope in this field, but I think that youāre gonna see real delivery and real significant strides and impacts on biology, health, and curing of diseases over the next 12 months, 18 months.ā
āI think itās gonna take time to really deliver on the full impacts, just by the nature of this field. But I think itās all possible and doable, and itās exactly the kind of thing we have these models that are solving these unsolved problems. Clearly, we need to apply it to biology and life sciences.ā
Jacob Coffman retweeted
alright, hereās the AI bull case after the elections (i believe this will play out):
- compute (data centers) will not get cancelled, theyāll be taxed more and thatāll result in an abundance of wealth for blue, red states. AI is a bipartisan issue.
- no ai bubble burst because data center buildout slows. canāt overbuild if you canātā¦ build.
- every ai lab, hyperscaler and neocloud agrees to every state leaders requests to remove subsidies, increase taxes blah blah (they make so much money they donāt care)
- stock market recovers dramatically because *checks notes* the long term outlook of AIās impact on the economy is still massively undersized.
goodnight.
man people really don't like AI. expect this to slow down a lot of momentum in the near-term (6-9 months):
around $400-750 billion worth of data center projects are now at risk of being shut down or paused next year.
25% of this is in texas where hyperscalers and labs have invested $100Bs to build data centers.
76% of people don't want them built in their community
don't think we've ever seen a topic so galvanizing as AI data centers, if you're pro-AI the perception of models, futures and outcomes need to be radically changed to be pro-human
the doomerism has won.
Jacob Coffman retweeted
Winning data center platform:
1/ no subsidies, no tax breaks
2/ make your own electricity, waterlessly
3/ equipment should be essentially inaudible at the fenceline
Jacob Coffman retweeted
Build more than ordinary life requires, because eventually life will require more than ordinary.
Fitness is mostly unused capacity...
My thoughts in the first reply.
Jacob Coffman retweeted
Underrated life advice: Your best years don't have to be behind you. You can be in the best shape of your life at 50. Start the company at 60. Fall in love at 70. Reinvent yourself at 80. Change doesnāt have an expiration date. Your best years are yours to create. So just start.