EMBO/Sandler PBBR/BARI postdoc at @UCSF. Stem cell biologist interested in early development/heterochrony/longevity using eusocial super agers (naked mole-rats)
San Francisco, CA
Joined September 2023
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New groundbreaking longevity research on naked mole-rats is out — excited to have contributed some piece to it. More to come!! 🧬🧫🔬🔥
biorxiv.org/content/10.64898…
Jonathan Bayerl retweeted
The reference map generated from this study in Cell Systems enables the benchmarking of #blastoids that may guide the optimization of the protocol for the generation of high-fidelity blastoid models that faithfully recapitulate the natural human #blastocyst.
Congratulations to first authors Siqu Long and Hani Jieun Kim of @syd_health, and their colleagues!
#OpenAccess: bit.ly/47Siivn
Jonathan Bayerl retweeted
A study published in @Nature reports that naked mole-rat queens produce a unique scent molecule called isopropyl myristate (IPM) which suppresses reproduction in other females, preventing power struggles and controlling social hierarchy. go.nature.com/4z8JfHA
Jonathan Bayerl retweeted
Efficient base editing and development in human embryos without chromosomal alterations biorxiv.org/content/10.64898…
Jonathan Bayerl retweeted
Excited to share our preprint, reviving @kristyredhorse's interest in the placenta from her PhD ~20 years ago! We find using 3D imaging that the mouse placenta is far more invasive than previously thought. Furthermore, we find a surprise from our favorite chemokine CXCL12...🧵:
3D imaging of the pregnant uterus reveals an extensively invasive mouse placenta requiring CXCL12-CXCR4 signaling biorxiv.org/content/10.64898… #biorxiv_devbio
Jonathan Bayerl retweeted
After 20 years, 58 generations and more than 30,000 cloning attempts, a team of researchers has hit the limit on the number of times a single mouse can be serially re-cloned
go.nature.com/47hykPQ
Jonathan Bayerl retweeted
Tam, T.T.K.K., Xu, S., Li, Y. et al. Amniogenesis in embryos and stem cell models. Nat Cell Biol (2026). doi.org/10.1038/s41556-026-0…
Jonathan Bayerl retweeted
Modeling human embryo implantation in vitro: Cell cell.com/cell/fulltext/S0092…
Jonathan Bayerl retweeted
Now online! Modeling human embryo implantation in vitro dlvr.it/TPzkPm
Jonathan Bayerl retweeted
🚨 BIG NEWS: The era of in vitro human embryo implantation has arrived! 🧬
We have successfully modeled the earliest stages of pregnancy in the lab using a new 3D "organoid uterus" platform. Published today in @CellCellPress: doi.org/10.1016/j.cell.2025.…
Jonathan Bayerl retweeted
Leverage on our human blastoid model we now establish a 3D in vitro model for studying human implantation and implantation failure: Cell cell.com/cell/fulltext/S0092… Congrats to all co-authors and collaborators, especially Hongmei Wang @CAS! So proud of my former trainees Leqian Yu and Yulei Wei who have made this finally happen in their own labs! This project started shortly after we published the first human blastoid model based on naive human pluripotent stem cells and it took several years of trial and errors with different strategies. I am happy to see now it has been successfully applied to study mechanisms underlying human implantation and implantation failure. More importantly our model helps screen FDA approved compounds that hold the potential to overcome repeated implantation failure.
Jonathan Bayerl retweeted
Findings may move science closer to growing organs in other species: Newsroom - UT Southwestern, Dallas, Texas utsouthwestern.edu/newsroom/…
Jonathan Bayerl retweeted
RNA innate immunity constitutes a barrier for interspecies chimerism: Cell cell.com/cell/fulltext/S0092…
Jonathan Bayerl retweeted
Despite high cell numbers and long lifespans, large animals don’t have higher cancer rates: Peto’s paradox. Elephants carry extra copies of tumor suppressor genes, while whales enhance DNA repair mechanisms! Fascinating that nature found different solutions to the same problem
Nature research paper: Evidence for improved DNA repair in long-lived bowhead whale
go.nature.com/3Lzg1NH
Jonathan Bayerl retweeted
Nature research paper: Evidence for improved DNA repair in long-lived bowhead whale
go.nature.com/3Lzg1NH
I am honored to express my opinion on this new approach in fertility and reprogramming -exciting times ahead!
Funktionsfähige Eizellen aus menschlichen Hautzellen erzeugt: Portland – Ein Forschungsteam aus den USA hat in einer Proof-of-Concept-Studie erstmals gezeigt, dass sich aus menschlichen Hautzellen befruchtbare Eizellen erzeugen lassen. Die in Nature… dlvr.it/TNPN0R
Jonathan Bayerl retweeted
Finally .. incredible much awaited wok on deriving avian naive ESCs
“Derivation of embryonic stem cells across avian species”
nature.com/articles/s41587-0…
Jonathan Bayerl retweeted
Scholarship, abstract and early registration deadlines:
1. Scholarship/Short Talk Abstract Deadline: October 21, 2025 (11:59pm MST)
2. Early Registration: December 18, 2025 (Save $200 – 11:59pm MST)
3. Poster Abstract Deadline: January 27, 2026 (11:59 MST)
Jonathan Bayerl retweeted
Scientists have for the first time ever filmed a crucial step that leads to new human life – cracking open a 'black box' of early development. @ojosnegros_sam @IBECBarcelona
sciencealert.com/world-first…
