John R. Ussher (@JussherLab) profile picture

John R. Ussher

@JussherLab

Proud father, loving husband, enthusiastic scientist, Detroit Red Wings & Lions diehard, trekkie/space lover, casual Madden player and Game of Thrones Fanatic

Joined March 2015
  • Tweets2.4K
  • Following1.1K
  • Followers883
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Photo by John R. Ussher (@JussherLab)Photo by John R. Ussher (@JussherLab)Photo by John R. Ussher (@JussherLab)Photo by John R. Ussher (@JussherLab)Photo by John R. Ussher (@JussherLab)Photo by John R. Ussher (@JussherLab)Photo by John R. Ussher (@JussherLab)Photo by John R. Ussher (@JussherLab)Photo by John R. Ussher (@JussherLab)Photo by John R. Ussher (@JussherLab)
Our LinkedIn page is now live! Give us a follow to stay up to date with all things SHVM 2025 and beyond #longlivemetabolism #SHVM 👇 linkedin.com/company/shvm
Society for Heart and Vascular Metabolism (SHVM) | LinkedIn

Society for Heart and Vascular Metabolism (SHVM) | LinkedIn

Society for Heart and Vascular Metabolism (SHVM) | 275 followers on LinkedIn. 23rd Annual Scientific Sessions: Aging as a gateway to cardiovascular-metabolic research | 26-29 October 2026 Osaka, Japan

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Stay tuned for further updates as we near the 22nd Annual SHVM meeting: Shedding Light on Emerging Metabolic Targets in Cardiovascular Diseases 🫀 Abstract submission 17 March 2025 Early bird registration 18 April 2025 Registration and payment deadline 15 May 2025
Image from Society for Heart and Vascular Metabolism (@Soc_HrtVasMetab)
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I'm looking to hire a fully funded PhD student this year. If you are interested in investigating mitochondrial bioenergetics in diverse tissues please reach out.
Image from Graham P Holloway (@HollowayMitoLab)
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Excited to share my work with @DanielJDrucker on the role for GIPR agonism alone and with GLP-1R agonism (@tirzepatide_ ) in the regulation of gut inflammation, and providing new insights on the localization of the GIP receptor in the gut. See paper here: insight.jci.org/articles/vie…
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Finally the latest baby of the Quebec PAH and vascular biology research group is out 😎. Congrats Dr Grobs @Grobs4 @3CPRCouncil @PVRI @ATS_PC @PullamsettiL @Savai_Lab @facmedUL science.org/doi/10.1126/scit…
ATP citrate lyase drives vascular remodeling in systemic and pulmonary vascular diseases through...

ATP citrate lyase drives vascular remodeling in systemic and pulmonary vascular diseases through...

ATP-citrate lyase is a target for therapeutic interventions in pulmonary hypertension and coronary artery disease.

science.org
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Using multiple techniques the authors affirm that Gfral expression is overwhelmingly restricted to the brainstem in healthy mice @MolMetab @cusm_muhc @seeleyrj sciencedirect.com/science/ar…
Image from Daniel J Drucker (@DanielJDrucker)
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Check our last review in the special issue of Essays in Biochemistry on AMPK and AMPK-related kinase👉AMPK and O-GlcNAcylation: interplay in cardiac pathologies and heart failure portlandpress.com/essaysbioc… @ISHR_ES @escardio @GRRC_SFCardio

AMPK and O-GlcNAcylation: interplay in cardiac pathologies and heart failure

Abstract. Heart failure (HF) represents a multifaceted clinical syndrome characterized by the heart’s inability to pump blood efficiently to meet the body’s metabolic demands. Despite advances in...

portlandpress.com
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The SUMMIT trial Tirzepatide for #HeartFailure with Preserved Ejection Fraction in PPL with #Obesity A lower risk of a composite of death from cardiovascular causes or worsening heart failure nejm.org/doi/full/10.1056/NE…
Tirzepatide for Heart Failure with Preserved Ejection Fraction and Obesity | NEJM

Tirzepatide for Heart Failure with Preserved Ejection Fraction and Obesity | NEJM

Obesity increases the risk of heart failure with preserved ejection fraction. Tirzepatide, a long-acting agonist of glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1 receptor...

nejm.org
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On #WorldDiabetesDay2024 congratulations to Professor Erin Mulvihill @HeartInstitute @OttawaU @uOttawaBMI @CIHR_IRSC this years receipient of the early career investigator award from @DiabetesCanada Felicitations! #diabetes
Image from Daniel J Drucker (@DanielJDrucker)
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John R. Ussher retweeted
Jason Dyck (@JasonRBDyck) profile picture
Jason Dyck@JasonRBDyck16 Oct 2024
Semaglutide Reduces Cardiomyocyte Size and Cardiac Mass in Lean and Ob... sciencedirect.com/science/ar…
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The Arany lab (@AranyLab) profile picture
The Arany lab@AranyLab15 Oct 2024
Reporting with pride: (1) our star Jessie Axsom is now Dr.! (2) her paper is out @Cell_Metabolism: unbelievably comprehensive quantification of fuel fluxes in #exercise mice - lots of surprises. #MoTrPAC: take note. w/Rabinowitz lab. Free link 50days: authors.elsevier.com/a/1jxL7…
Image from The Arany lab (@AranyLab)
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See our new review on #AMPK and O-GlcNAcylation: interplay in cardiac pathologies and heart failure portlandpress.com/essaysbioc… #heartfailure #Essays @ISHR_ES @GRRC_SFCardio @escardio
Image from Luc Bertrand (@BertrandLuc_ky)
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🚨New Paper Alert🚨 Our new #microbiome research, co-led with @LiatShenhav, published today in @CellCellPress! We show that #breastfeeding "paces" gut & nasal microbiome development to prevent #asthma in the @CHILDSTUDY. #Tweetorial 🧵 cell.com/cell/fulltext/S0092…
Image from Prof. Meghan Azad, PhD (@MeghanAzad)
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New data from the Shulman lab provide insights into the mechanisms by which inhibition of ceramide synthesis, by either myriocin or Des1 ASO treatment, protects rodents from lipid-induced hepatic #insulin resistance cell.com/cell-reports/fullte… @CellReports

Ceramide synthesis inhibitors prevent lipid-induced insulin resistance through the DAG-PKCε-insulin...

Here, Xu et al. show that inhibition of de novo ceramide synthesis by either myriocin treatment or DES1 knockdown protects against lipid-induced hepatic insulin resistance independently of C16...

cell.com
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John R. Ussher retweeted
XX (@bcellorg) profile picture
XX@bcellorg18 Sep 2024
An exhaustive review from @mferdaoussi on insulin secretion. “Metabolic and Molecular Amplification of Insulin Secretion” pubmed.ncbi.nlm.nih.gov/3928…
Image from XX (@bcellorg)
Image from XX (@bcellorg)
Image from XX (@bcellorg)
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Thank you from the organizers and board members for a great meeting. See you next year in Bordeaux! 👏
Image from Society for Heart and Vascular Metabolism (@Soc_HrtVasMetab)
Image from Society for Heart and Vascular Metabolism (@Soc_HrtVasMetab)
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Hot off the press: Muscle Matters: the Impact of Medically Induced Weight Loss on Skeletal Muscle. thelancet.com/journals/landi… @TheLancetEndo Pérdida de masa muscular con medicamentos para la pérdida de peso. Perda da massa muscular com medicamentos para perda de peso. “Regulatory agencies should provide more comprehensive guidelines for monitoring and evaluating body composition changes, mandate well-designed body composition studies, and enhance post-market surveillance." "GLP-1 receptor agonists have revolutionized obesity treatment and demonstrated substantial benefits... However, the potential impact of muscle mass loss as now observed remains a concern. These highly effective medications should be used strategically, in a multimodal approach to improve the quality of weight loss by optimizing body composition." Thanks to my dear colleagues/friends: @mackinprof @Kryz5559 and Steven Heymsfield for their partnership! @UofAALES @AlbertaDiabetes @UofAResearch Figure: Dual role of muscle as both a structural and metabolic organ.
Muscle matters: the effects of medically induced weight loss on skeletal muscle

Muscle matters: the effects of medically induced weight loss on skeletal muscle

The importance of skeletal muscle mass is increasingly being recognised in the medical field.1 The crucial roles of skeletal muscle have come to the forefront of public attention due to data on the...

thelancet.com
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Some thoughts on: Intermittent fasting immunity and metabolism cell.com/trends/endocrinolog…
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Online now! Mitochondrial transplants to treat mitochondrial dysfunction dlvr.it/TCjPm9
Image from Nature Metabolism (@NatMetabolism)
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Ian Scott (@iscotthsc) profile picture
Ian Scott@iscotthsc30 Aug 2024
Two great opportunities in Toronto! apply.interfolio.com/152420
Image from Ian Scott (@iscotthsc)
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