@KapahiLab

Kapahi laboratory at @BuckInstitute. Studying #aging #diet #metabolism #diabetes #AGEs #glycation #neurodegeneration @gly_low

 Novato, CA
buckinstitute.org/lab/kapahi-lab/
Joined May 2022
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  • Following31
  • Followers106
9Media
authors.elsevier.com/a/1nZNE… Delighted to share that our Perspective, “Why Studying Females Reveals More About Aging: The Reproductive Resilience Hypothesis for the evolution of Sex-Specific Aging,” was published in @CellCellPress. 1/n
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Hot off Buck Blog press! Meet Dr. Parminder Singh from @KapahiLab. Dr. Singh's research explores how communication between organs influences biology of aging, uncovering new insights into mechanisms that drive health and longevity. buckinstitute.org/blog/faces… @Parminder_S94

Faces of Discovery:Parminder Singh, PhD

A new monthly installment to the Buck Blog, introducing the scientists unraveling the mysteries of aging and pioneering ways to help us all live better longer.

buckinstitute.org
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New publication from @KapahiLab! Link here shorturl.at/MyEfV We used computational modeling on data collected during my PhD in >150 #Drosophila strains to find traits that predict lifespan and healthspan across different genotypes in response to dietary restriction. (1/3)

Systems biology approaches identify metabolic signatures of dietary lifespan and healthspan across...

Nature Communications - Here, the authors use multi-organism machine learning to identify conserved metabolites modulating aging and healthspan in flies and humans. Threonine showed protective...

nature.com
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Really nice write-up in @Forbes by @WmHaseltine about our recent @NatureComms article. I'm excited about the potential of this work and where it will go next! forbes.com/sites/williamhase…
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A study in @NatureComms identifies a mechanism that contributes to how dietary restriction promotes healthy brain aging. go.nature.com/3UjCa5k
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We had a fun lab outing and team building day. Making it out of the Escape room and Chinatown visit was fun with this great group of talented and fun peeps.
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A study in @NatureComms identifies a mechanism that contributes to how dietary restriction promotes healthy brain aging. go.nature.com/3RXsQRu
This is figure 2, which shows that mtd interacts with the retromer complex and is required for retromer maintenance.

ALT This is figure 2, which shows that mtd interacts with the retromer complex and is required for retromer maintenance.

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I'm deeply saddened to share that we have lost a remarkable friend, a wonderful mentor and esteemed colleague, Judith Campisi. Judith's impact on those around her was profound and lasting. Her legacy will continue to inspire us all. Rest in peace, Judy. You will be greatly missed
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Kapahi Lab retweeted
Thrivous
@thrivous17 Jan 2024
Scientists found a gene called OXR1 controls brain aging when diet is restricted. Works like a traffic cop for proteins and fats, keeping things in order. Without it, age-related mishaps may increase. #ScienceNews pubmed.ncbi.nlm.nih.gov/3821…

OXR1 maintains the retromer to delay brain aging under dietary restriction - PubMed

Dietary restriction (DR) delays aging, but the mechanism remains unclear. We identified polymorphisms in mtd, the fly homolog of OXR1, which influenced lifespan and mtd expression in response to DR....

pubmed.ncbi.nlm.nih.gov
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Join the Kapahi Lab at the Buck Institute as a Research Associate! Unlock the secrets of the hallmarks of aging! Job Link: app.jobvite.com/j?cj=oLVYqfw… #sciencejobs #researchjobs @kapahi_pankaj
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Join the Kapahi Lab at the Buck Institute as a Research Associate! Unlock the secrets of the hallmarks of aging! Job Link: app.jobvite.com/j?cj=oLVYqfw… #sciencejobs #researchjobs @kapahi_pankaj
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OXR1 maintains the retromer to delay brain aging under dietary restriction 👉XR1 plays a conserved role in preserving retromer function and is critical for neuronal health and longevity. @_KAWilson_, @kapahi_pankaj nature.com/articles/s41467-0… @NatureComms
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Scientists identify how #dietaryRestriction slows #brain aging and increases lifespan @NatureComms doi.org/gtc9b6 medicalxpress.com/news/2024-…
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Congrats @kapahi_pankaj & @ellerby_lisa labs! Study posted in @NatureComms ➡️how #dietaryrestriction slows brain aging and increases lifespan. Mechanism, involving OXR1, provides potential targets to slow aging and age-related #neurodegenerativediseases buckinstitute.org/news/buck-…

Buck Scientists Identify How Dietary Restriction Slows Brain Aging & Increases Lifespan

The mechanism provides potential therapeutic targets to slow aging and age-related neurodegenerative diseases

buckinstitute.org
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The newest work from our lab is published today in @NatureComms! We find that dietary restriction drives OXR1 expression to protect the brain with age, with potential benefits in age-related diseases! See the thread here for more details.
Kenny Wilson@_KAWilson_11 Jan 2024
Pleased to share my newest publication about OXR1, a gene that protects the aging brain, published today in @NatureComms! A thread describing the results below 👇, and here is a link to the article: nature.com/articles/s41467-0… @KapahiLab #Drosophila #aging #longevity #retromer

OXR1 maintains the retromer to delay brain aging under dietary restriction

Nature Communications - Dietary restriction promotes healthy brain aging, but the mechanism is unknown. Here, the authors show that OXR1 is upregulated by dietary restriction and confers...

nature.com
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Replying to @_KAWilson_
@_KAWilson_ presents his postdoctoral work from @KapahiLab and Ellerby lab at #BAAM2023! Kenny's work on a gene that preserves the brain with age was accepted today for publication @NatureComms!
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Buck professor @kapahi_pankaj chairs the second session of the day at #BAAM2023 on aging and rejuvenation.
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About to get underway at the Bay Area Aging Meeting @Stanford! The Buck is proud to be a co-organizer of this semi-annual symposium! #BAAM2023
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I enjoyed doing this podcast on various topics in aging from calorie restriction to glycation
Longevity India@longevity_ind19 Sep 2023
Caloric Restriction: The Secret to Longer Lifespan? Listen to the entier podcast of Longevity India with @kapahi_pankaj from Buck Institute for Research on Aging in the house, revealing the secrets of advanced glycation end products and their effects on our bodies over time.
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Our tiny lab worms reveal big insights! My new @eLife study shows Advanced Glycation End-products (AGEs) in processed foods caused worms to overeat. Check out! doi.org/10.7554/eLife.82446 @KapahiLab @BuckInstitute @ellie_elegans @theElegantWorm @AM_OMRF @americanaging @ScienceNews

Methylglyoxal-derived hydroimidazolone, MG-H1, increases food intake by altering tyramine signaling...

Advanced glycation end-products (compounds which make the food appetizing and aromatic) intricately modulate organism’s homeostatic and hedonistic signaling pathways thereby inducing preferential...

elifesciences.org
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