@KaramLab

Tumor Immunology, TME, Systemic Immunity, Radiation Oncology, Wash U

 Saint Louis, MO
medschool.cuanschutz.edu/radiation-oncology/research/karam-lab
Joined November 2020
  • Tweets1.9K
  • Following602
  • Followers1.7K
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Sana Karam, MD, PhD retweeted
Amir Safavi
@safaviaaOct 22
Now in @JAMAOnc: We report 5y outcomes post 30 Gy elective RT (total 70 Gy CCRT) for 276 pts w/ HPV-related OPC #hncsm at @MSKCancerCenter #radonc LRC 97.0% OS 90.8% PFS 85.9% DMFS 91.2% @imrtlee @xrtGenomics @seanmmcbride @CJTsaiMDPhD @EChrisDee 👉 shorturl.at/liqpP
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Sana Karam, MD, PhD retweeted
Shannon Jiang@ShannonJiangMDOct 17
Asking patients to take endocrine therapy for 5+ years is easier said than done. We found that maintaining long-term adherence can be challenging for patients with breast cancer, particularly those who omit radiation. @WashUMedRadOnc @washumedicine @SitemanCenter
ASTRO
@ASTRO_orgOct 16
News from #ASTRO26: Real-world data indicate lower adherence rates for breast cancer endocrine therapy when radiation therapy is omitted Nationwide insurance claims analysis finds fewer than 30% of patients remained adherent for five years after lumpectomy. As seen in @Inside_PM, @AuntMinnie, HealthDay News, @cure_today & more. Presented by Shannon Jiang, MD. Learn more: bit.ly/4ywQlUV @WashUMedRadOnc @ShannonJiangMD
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Sana Karam, MD, PhD retweeted
C. Jillian Tsai, MD, PhD@CJTsaiMDPhDSep 27
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Sana Karam, MD, PhD retweeted
C. Jillian Tsai, MD, PhD@CJTsaiMDPhDSep 27
🚨‼️Happening now - technology driven strategies for HNSCC. First talk - @imrtlee on FMISO pooled analyses. #ASTRO26 @ASTRO_org @xrtGenomics @seanmmcbride @MSK_RadOnc
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Sana Karam, MD, PhD retweeted
C. Jillian Tsai, MD, PhD@CJTsaiMDPhDSep 27
👏⚡️Dr. Huang from Sun Yat-Sen presented stellar 10yr Outcomes of Elective Upper vs. Whole-Neck RT for the Uninvolved Neck in NPC with preRT high EBV viral load! #ASTRO26 @ASTRO_org @DavidSherMD @KaramLab @ScottBratman
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Sana Karam, MD, PhD retweeted
C. Jillian Tsai, MD, PhD@CJTsaiMDPhDSep 27
🦠💡Next up - TRINITY trial presented by Zachary Zumsteg at @CedarsSinai, investigating reduced dose/volume CRT after TORS with excellent 2-yr PFS. #ASTRO26 @ASTRO_org @xrtGenomics @DanielMaMD @RobertFerrisMD @drdavidpalma
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Thrilled to share our latest work out now in CIR. We uncovered paradoxical role of EphA4 in HNSCC: it drives tumor growth when in Tregs, but suppresses it in CD8+ T cells, myeloid cells, and cancer cells. The secret? Upstream negative regulation of AKT. pubmed.ncbi.nlm.nih.gov/4264…
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A broader lesson from this journey: beware of pleiotropic effects. Not everything that goes "up" is inherently bad, and vice versa. Our story started by simply seeing EphA4 upregulated during therapeutic resistance, but years of functional manipulation uncovered the biology.
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Huge shoutout to first author Sophia Corbo and the entire Karam Lab team who always make things happen! Massive thanks to our wonderful collaborators Enrique Sanz Garcia & Lillian Siu (Princess Margaret/U of Toronto) and Elena B. Pasquale (Sanford Burnham Institute).
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Congratulations @carmenbergom on this well-deserved recognition! @SitemanCenter @WashUDPS
ASTRO
@ASTRO_orgAug 28
2026 ASTRO Fellow Spotlight Series: Congratulations to Carmen Bergom, MD, PhD, from the Washington University School of Medicine on being named a 2026 ASTRO Fellow! We look forward to recognizing you at #ASTRO26. View the list of 2026 Fellows: bit.ly/4pTnnM8 @carmenbergom @WashUMedRadOnc @washumedicine @SitemanCenter
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Big news in our Div of Medical Physics! Our #medphys MS & Certificate programs have been reaccredited by CAMPEP & our PhD program has been granted initial accreditation!! WashU now has a full complement of CAMPEP-accredited Medical Phys training programs! bit.ly/4ca63wX
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Sana Karam, MD, PhD retweeted
WashUMedENT@WashUMedENTAug 21
It is our pleasure to announce that Andrés Bur, MD, FACS will be joining WashU Medicine as Chief of the Division of Head and Neck Surgery in the Department of Otolaryngology–Head & Neck Surgery! Please join us in congratulating Dr. Bur!
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Sana Karam, MD, PhD retweeted
Sid Puram, MD PhD (Puram Lab)@SidPuramAug 23
Stoked to share our new paper w/ @TiroshLab in @NatureGenet! Using spatial multi-omics we characterized two distinct modes of p-EMT in HNSCC, each with their own distinct ecosystems and drivers. #SpatialTranscriptomics #HNSCC #Visium #CODEX #EMT nature.com/articles/s41588-0…
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Sana Karam, MD, PhD retweeted
Jonathan Kipnis 🟦
@jonykipnisAug 19
Excited to share our new work by Jay Park @janghyun_park_ and friends! Jay found lymphoid structures in the skull bone marrow that seem to be serving immune hub role for the brain... brain, after all, may not be using "common lymph nodes" but rather has its own unique immune hubs and Jay showed their role in brain tumors... but their role in likely much more than that. This is a long paper but it is worth the read || nature.com/articles/s41586-0…

Functional role of skull lymphoid structures in CNS immunosurveillance

Nature - Functional lymphoid structures within the skull bone marrow enable central nervous system immunosurveillance and shape immune responses to brain disease.

nature.com
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Congratulations to @jmmrad! He will be awarded tonight at #AAPMcomp2026 with honorary membership in @aapmHQ for his support for the mission and goals of AAPM through leadership and advocacy! 🙌
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