We are studying the heterogeneity, origins and in-vivo tissue specific functions of murine mononuclear phagocytes in health and disease.
Chicago, IL
Joined May 2019
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We are thrilled to share that our paper is now published in @ImmunityCP . It'sbeen a long journey and I'm incredibly grateful to all my co-authors, especialy @Teruyuki_Sano , for your dedication and collaboration.
cell.com/immunity/fulltext/S…
Ki-Wook Kim Lab retweeted
New Review: Tomás S. Huerta, @KevinJTraceyMD, Isaac M. Chiu & @changsbrain review the organization & function of vagal neuroimmune circuits, from afferent cytokine sensing to organ-specific efferent immune control. hubs.la/Q04ykWBh0
#BioelectronicMedicine #Neuroimmunology
Ki-Wook Kim Lab retweeted
New paper from the Colonna lab! cMAF is a key regulator of BAM identity and drives communication with brain arteries via IGF1. We show that this cMAF-dependent program in BAMs supports cerebrovascular function in mice and is protective against AD.
cell.com/cell/fulltext/S0092…
Ki-Wook Kim Lab retweeted
Online now: CD163+ red pulp macrophages interact with marginal metallophilic macrophages during blood-stage malaria to maintain splenic architecture dlvr.it/TTs7SK
Ki-Wook Kim Lab retweeted
Excited to share 🔬🧬:
A collaborative study from @WashUMedicine - advancing our understanding of the distinct developmental origins and pathways of macrophage populations.
Proud to have contributed!!!
🐻❤️💚
@WashU @washupathedu @WUSTLImmuno #ADAPT3D
science.org/doi/10.1126/scii…
Ki-Wook Kim Lab retweeted
Online now: Disease-associated microglia adopt stage-specific phenotypes that regulate T cell fate and immunity in glioma dlvr.it/TThWVw
Ki-Wook Kim Lab retweeted
Congrats to postdoc @rofu47 on his 🔥paper out in @ImmunityCP. This gives strong internal conviction that bioelectronic med has many use cases & so much more to the vagus nerve!
Activation of the auricular vagus nerve reflex suppresses airway infla... sciencedirect.com/science/ar…
Ki-Wook Kim Lab retweeted
Nature Reviews Gastroenterology&Hepatology
Full article
rdcu.be/fskkn
@NatRevGastroHep @JAMASurgery @Nature @LancetGastroHep @NEJM @RCSI_Irl @MedicineAtUL @SWexner @juliomayol @DCREdInChief
Ki-Wook Kim Lab retweeted
Salmonella bacteria lurk in raw meat, on pets and in unpasteurized dairy products.
UIC researcher Kiwook Kim asked why some salmonella infections stay in the intestine while others evolve to be life-threatening.
📰today.uic.edu/how-immune-cel…
📗doi.org/10.1084/jem.20251492
ALT Kiwook Kim.
Ki-Wook Kim Lab retweeted
Macrophages in embryonic development dlvr.it/TTJxQ3
Ki-Wook Kim Lab retweeted
Review @SciImmunology @E_v_a_Kaufmann @MazDivangahi @mcgillu
Innate immune memory is reviewed as a life-span adaptation shaped by evolutionary origins, epigenetic-metabolic mechanisms, and the exposome
science.org/doi/10.1126/scii…
We are excited to share our new publication in the @JExpMed . Dr. Jiseon Kim, who has been conducting over the past four years, led this study in collaboration with @jkyeom. I would like to sincerely thank Jiseon and co-authors for their contributions.
New study from Jiseon Kim, Jinki Yeom, Ki-Wook Kim et al. found that mesenteric #macrophage-#monocyte interactions control the magnitude of gut-mesentery #inflammation and its progression to systemic infection following enteric pathogen infection. hubs.la/Q04dSgBH0
6. Il1r1 ko and anti-IL-1R Ab treatment improve survival following STm infection, indicating the dysregulated IL-1b signaling from activated monocytes drives increased mortality.
5. Depletion of mesentery-resident macrophages accelerates mortality and exacebates systemic STm infection, accompanied by excessive recruitment of activated monocytes with hightened expression of inflammatory cytokines.
4. During STm infection, activated monocytes are sustantially recruited to mesentery. Although monocytes serve as major cellular sources of inflammatory cytokines, they are not involved in neutrohil efferocytosis.
3. During STm infection, mesentery-resident macrophages become activated, and monocyte-derived MFs (Mo-MFs) and neutrophils are recruited to mesentery prior to systemic dissemination of STm. Excessively recruited neutrophils are cleared by CX3CR1+ MFs, but not by other MFs.
2. Using Ccr2ko, Cx3cr1- and Ms4a3-mediated fate mapping models, we demonstrated LYVE1hi TIM4(-) and LYVE1lo/- CX3CR1+ MFs are replenished by GMP-derived monocytes, whereas LYVE1hi TIM4(+) MFs originate from CX3CR1+ embryonic precursors.
1. We indentified three distinct mesentery-resident MFs: LYVE1hi TIM4(+), LYVE1hi TIM4(-), and LYVE1lo/- CX3CR1+ populations. Notably, MHC II epxression in CX3CR1+ and LYVE1hi TIM4(-) MFs was reduced under GF condition, implying they are influenced by commensal-derived signals.
Ki-Wook Kim Lab retweeted
During enteric bacterial infection, mesentery-resident macrophages act as a regulatory hub that controls the recruitment of inflammatory monocytes with elevated pro-inflammatory cytokine expression @JExpMed @KiwookKimLab @uiccom 🇺🇸🇰🇷
rupress.org/jem/article/223/…
Ki-Wook Kim Lab retweeted
NF-κB-activated fibroblasts orchestrate inflammaging and emergence of pro-inflammatory granzyme K+ T cells: Immunity cell.com/immunity/fulltext/S…
Excited to present Nancy's postoctoral work @ucsfaging @immunox defining the role of aging fibroblasts in driving inflammaging.