@KuchrooLab

Lab of Prof. Vijay Kuchroo @GeneLayInst @BrighamWomens @HarvardMed @BroadInstitute. Posts by lab members unless signed by VKK. Views are our own.

 Boston
kuchroolab.bwh.harvard.edu/
Joined May 2020
  • Tweets190
  • Following313
  • Followers2.6K
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New publication in Immunity! Researchers from the Gene Lay Institute, led by Dr. Caroline Sokol and Dr. Xueping Zhu, identified mTORC1 as a molecular switch that helps sensory neurons “remember” allergen exposure—driving heightened itch and allergic responses upon re-exposure.
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Honored to welcome Dr. Shimon Sakaguchi, the 2025 Nobel Laureate, for a fireside chat at the Gene Lay Institute with our trainees. His pioneering work in regulatory T cells has transformed our understanding of immune tolerance. Watch the highlight below. #GeneLayInstitute
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Science, collaboration, and community! Yesterday we gathered for our monthly science meeting and heard from three of our talented Gene Lay Institute Postdoctoral Fellows. We love seeing our community come together to share feedback, support new research, and catch up.
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Celebrating 34 years of the Kuchroo Lab and honoring our Director, Vijay Kuchroo! Past and present lab members came together on Cape Cod to celebrate decades of discovery, collaboration, mentorship, and hard work.A wonderful reminder of the lasting community built over the years.
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Join the Gene Lay Institute on October 2nd for our Tissue Inflammation Workshop! Hear from leading scientists in neuroimmunology, present your research in our trainee poster session, and connect with experts. Register today! #GeneLayInstitute
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cell.com/cell/fulltext/S0092…

Brain perivascular macrophages regulate endothelial cell function via a cMAF-dependent transcript...

This study identifies cMAF as a key transcription factor that orchestrates the molecular crosstalk between brain perivascular macrophages and arteries, thereby sustaining cerebrovascular function in...

cell.com
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New research from @JoonHyukLee3 & @QuintanaLabHMS shows that astrocytes level-up as non-professional antigen-presenters after interactions with T cells to boost T cell pathogenicity in 🧠CNS autoimmunity. @MGBResearch @HarvardMedical @BroadInstitute nature.com/articles/s41586-0…
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Excited to welcome Dr. Shimon Sakaguchi to The Gene Lay Institute today for a fireside chat on scientific career journeys and advice for young researchers!
🤖 Made with AI
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Thank you Dr. Sakaguchi for inspiring our trainees today! Stay tuned for video highlights coming soon.
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Kuchroo Lab retweeted
IdoAmitLab@IdoAmitLabJul 15
📢 New dates for ReThink Neuroimmunology: May 24–26, 2027, at the Weizmann Institute of Science. Join our spectacular international speaker lineup for bold science and deep discussions. Registration is open. Space is limited: conferences.weizmann.ac.il/R… #RTN2027 #Neuroimmunology
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🎉 Celebrating 3 Years of Impact! 🎉 On June 26, The Gene Lay Institute proudly celebrated its 3rd anniversary alongside our valued members. This milestone reflects the dedication, collaboration, and shared vision of everyone who has been part of our journey. #GeneLayInstitute
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What an incredible day at the @GeneLayInst 's inaugural retreat on April 27, 2026! 🎉 Watch the retreat highlights below! 🎥⬇️ #GeneLayInstitute #Immunology #Research #LifeSciences #TeamScience #ScientificCollaboration
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Kuchroo Lab retweeted
Xavier Lab@TheXavierLabJun 18
Join us and @GeneLayInst on July 31st for the Annual Symposium! This year's speakers include Marco Colonna, Shimon Sakaguchi, @stefanispranger, and @victora_lab. Register using the QR code in the flyer! #inflammation #immunity #disease #genelayinstitute
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Kuchroo Lab retweeted
Immunity@ImmunityCPJun 12
Online now: A cell-intrinsic glucocorticoid biosynthesis and sensing circuit maintains a homeostatic Th17 cell state dlvr.it/TT1F78

A cell-intrinsic glucocorticoid biosynthesis and sensing circuit maintains a homeostatic Th17 cell...

Th17 cells can either preserve homeostasis or drive inflammation in tissues; however, the mechanisms that maintain homeostatic phenotypes are not well defined. Yang et al. uncover a cell-intrinsic...

cell.com
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Kuchroo Lab retweeted
Immunity@ImmunityCPJun 12
Online now: Interleukin 23 promotes a pro-inflammatory Th17 cell state by stabilizing RORγt and suppressing glucocorticoid receptor activity dlvr.it/TT1JQ4

Interleukin 23 promotes a pro-inflammatory Th17 cell state by stabilizing RORγt and suppressing...

How IL-23 drives an inflammatory Th17 cell state is poorly understood. Yang et al. identify two coordinated mechanisms specific to IL-23R signaling: the recruitment of CHD1 to stabilize RORγt...

cell.com
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Kuchroo Lab retweeted
Waggoner Lab@LabWaggonerJun 15
IL-23 promotes a pro-inflammatory Th17 cell state by stabilizing RORγt and suppressing glucocorticoid receptor activity @ImmunityCP @KuchrooLab @nir_yosef1 @WeizmannScience @harvardmed cell.com/immunity/fulltext/S…
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A new Science #Immunology study addresses recent, conflicting findings on the role of #IL17 in #MultipleSclerosis, showing that IL-17A and IL-17 drive disease in EAE mouse model. @KuchrooLab scim.ag/3OtoiF7
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Kuchroo Lab retweeted
Waggoner Lab@LabWaggonerApr 24
B cells are a critical adaptive immune cell type in the development of TH17 cell–mediated experimental autoimmune encephalomyelitis @SciImmunology science.org/doi/10.1126/scii… @KuchrooLab @BrighamWomens
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In this review, Adam, Suhail, Kuchroo, and Vignali highlight the challenges and novel approaches to developing agonistic inhibitory receptor (IR)-targeted therapies to treat #autoimmunity and inflammatory disorders. hubs.la/Q0493L5y0 #CancerFocus #LymphocyteBiology
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Kuchroo Lab retweeted
Waggoner Lab@LabWaggonerApr 1
Tim-3 restrains ILC2 function and attenuates airway hyperreactivity via NLK pathway @NatureComms @KECKSchool_USC nature.com/articles/s41467-0…
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