Co-Founder / Director @elsiebio. Full time chemist. Part time adult.
San Diego, CA
Joined September 2011
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- Following247
- Followers168
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Kyle Knouse, Ph.D. retweeted
In @ScienceMagazine this week, @BaranLabReads expands the generality of their P(V) platform for selective oligonucleotide synthesis science.org/doi/10.1126/scie…
Kyle Knouse, Ph.D. retweeted
Appearing today in @ACSCentSci is an outlook on P(V) chemistry written with the BMS team: bit.ly/3nhDzbW
It’s a P(V) world and we’re just living it in. The fully P(V) approach from #bmschemistry gave 5.8 x yield of these otherwise challenging molecules and enabled toxicology delivery! pubs.acs.org/doi/pdf/10.1021… – at San Diego, CA
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Kyle Knouse, Ph.D. retweeted
Great opportunity to join a company at the very start of its journey!!!!
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Kyle Knouse, Ph.D. retweeted
In 2016, with @EastgateMartin and the @bmsnews team we set out to simplify the way Oligonucleotides therapeutics (OTs) are made. Access to a 3-10-3 LNA/DNA gapmer with 4 different P-linkages had pushed the limits of known chem. Today we report a solution: bit.ly/3a9FlV5
The final version of the manuscript appeared online today!
Modify DNA as if it were a simple alcohol derivative: Possible now with SENDR, appearing today in @ACSCentSci : pubs.acs.org/doi/abs/10.1021… For a behind-the-scenes look at SENDR and bioconjugation, visit Open Flask: bit.ly/2StPdjj
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Kyle Knouse, Ph.D. retweeted
Synthetic Elaboration of Native DNA by RASS (SENDR) by Philip Dawson & co-workers
doi.org/10.26434/chemrxiv.12…
Kyle Knouse, Ph.D. retweeted
Check out this awesome collaborative paper from my former undergrad @KyleKnouse in the @BaranLabReads teaming up with the @Dawson_Group group using the slick DNA chemistry he developed. The @wuestlab is proud of you! #DoingBetter
In this latest addition of collaborative work with @baranlabreads, we present SENDR with this shared tweet thread!
chemrxiv.org/articles/Synthe…
Kyle Knouse, Ph.D. retweeted
In this latest addition of collaborative work with @baranlabreads, we present SENDR with this shared tweet thread!
chemrxiv.org/articles/Synthe…
Kyle Knouse, Ph.D. retweeted
Excited to share our latest preprint! Fun exploring the Se-lective chemistry of Selenomethionine! chemrxiv.org/articles/Seleno…
10/10 recommend this class for any chemist!
Monday the fun begins. Since 2013, over 2000 chemists have enrolled. Register here for Heterocycles 2019 (free): itunes.apple.com/us/course/h… (heterocycle-infused espresso shots are free too if you attend in person)
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Kyle Knouse, Ph.D. retweeted
Took this CV spectrum by La Jolla beach 🙌😎
Guess which compound I used?
@IKAworldwide #RideTheWave @BaranLabReads
Wow, cyclic-TRI-nucleotides! – at San Diego, CA
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Kyle Knouse, Ph.D. retweeted
A PORTAL TO DEEPLY REDUCING CHEMISTRY via e-chem. A collaboration with @MinteerLab, @pfizer, Neurock lab, and others via @UtahCSOE : bit.ly/2BNLSUc. Behind the scenes account here: bit.ly/2Sf3HAZ Must-see video here: bit.ly/2GVLzdt. GIF-based TOC:
Hugh Jackman dancing and eating an apple (Greatest Showman audition) is the theatrical representation of discussing your latest chemistry results with @BaranLabReads 😂 – at San Diego, CA
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Such a cool strategy for such a difficult target! – at San Diego, CA
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Love this paper. Mike would be so proud! @EastgateMartin – at San Diego, CA
This week's quiz is another industrial synthesis, this one a J. Org. Chem. @JOC_OL paper from the process group at BMS. They synthesized gram quantities of duocarmycin SA for antibody-drug-conjugate studies. Good luck! dkfz.de/en/drugs/Synthesis_Q…
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Kyle Knouse, Ph.D. retweeted
Pharma mega-mergers are back! BMS bidding $74b for Celgene. My story: cen.acs.org/pharmaceuticals/…