Co-Founder / Director @elsiebio. Full time chemist. Part time adult.
San Diego, CA
Joined September 2011
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Kyle Knouse, Ph.D. retweeted
In @ScienceMagazine this week, @BaranLabReads expands the generality of their P(V) platform for selective oligonucleotide synthesis science.org/doi/10.1126/scie…
Kyle Knouse, Ph.D. retweeted
Appearing today in @ACSCentSci is an outlook on P(V) chemistry written with the BMS team: bit.ly/3nhDzbW
Kyle Knouse, Ph.D. retweeted
Great opportunity to join a company at the very start of its journey!!!!
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Kyle Knouse, Ph.D. retweeted
In 2016, with @EastgateMartin and the @bmsnews team we set out to simplify the way Oligonucleotides therapeutics (OTs) are made. Access to a 3-10-3 LNA/DNA gapmer with 4 different P-linkages had pushed the limits of known chem. Today we report a solution: bit.ly/3a9FlV5
Kyle Knouse, Ph.D. retweeted
Synthetic Elaboration of Native DNA by RASS (SENDR) by Philip Dawson & co-workers
doi.org/10.26434/chemrxiv.12…
Kyle Knouse, Ph.D. retweeted
Check out this awesome collaborative paper from my former undergrad @KyleKnouse in the @BaranLabReads teaming up with the @Dawson_Group group using the slick DNA chemistry he developed. The @wuestlab is proud of you! #DoingBetter
In this latest addition of collaborative work with @baranlabreads, we present SENDR with this shared tweet thread!
chemrxiv.org/articles/Synthe…
Kyle Knouse, Ph.D. retweeted
In this latest addition of collaborative work with @baranlabreads, we present SENDR with this shared tweet thread!
chemrxiv.org/articles/Synthe…
Kyle Knouse, Ph.D. retweeted
Excited to share our latest preprint! Fun exploring the Se-lective chemistry of Selenomethionine! chemrxiv.org/articles/Seleno…
Kyle Knouse, Ph.D. retweeted
Took this CV spectrum by La Jolla beach 🙌😎
Guess which compound I used?
@IKAworldwide #RideTheWave @BaranLabReads
Kyle Knouse, Ph.D. retweeted
A PORTAL TO DEEPLY REDUCING CHEMISTRY via e-chem. A collaboration with @MinteerLab, @pfizer, Neurock lab, and others via @UtahCSOE : bit.ly/2BNLSUc. Behind the scenes account here: bit.ly/2Sf3HAZ Must-see video here: bit.ly/2GVLzdt. GIF-based TOC:
Kyle Knouse, Ph.D. retweeted
Pharma mega-mergers are back! BMS bidding $74b for Celgene. My story: cen.acs.org/pharmaceuticals/…
Kyle Knouse, Ph.D. retweeted
My favorite papers challenge biomedical dogma. Here's my summary of the ones in 2018 that provided evidentiary shakeups.
Kyle Knouse, Ph.D. retweeted
First ever tweet! Thought I would highlight some #BMSChemistry papers from 2018, as it’s the end of the year. My fav has to be our Science paper with @BaranLabReads. PSI reagents?
science.sciencemag.org/conte…
Kyle Knouse, Ph.D. retweeted
Better CRISPR Through Chemistry and Collaboration mcgill.ca/chemistry/channels… via @mcgillu @McGillChemistry
Kyle Knouse, Ph.D. retweeted
Fortunately this won't stop you from publishing them in JACS now – at Philadelphia, PA
Kyle Knouse, Ph.D. retweeted
A great day for oligonucleotide therapeutics; the first RNAi approval!
Congrats $ALNY!
In the 12 yrs since the Fire and Mello Nobel Prize for discovering RNAi, a ton of outstanding science has brought us to this point, and to many more RNAi / other oligo drugs coming along.
$ALNY 16 years and accumulated deficit of >$2.38 billion to first FDA approval
#DrugDevCost
onpattro.com/
Kyle Knouse, Ph.D. retweeted
Scripps Research and @bmsnews scientists create 'atomic glue gun' to build better nucleic acid therapeutics bit.ly/2MkBrL8 #chemistry @BaranLabReads
Kyle Knouse, Ph.D. retweeted
Antisense and cyclic dinucleotide drugs can be made to exact chiral form, with new manufacturing technology outlined in Science by @scrippsresearch and @bmsnews scientists.
sandiegouniontribune.com/bus…
@BaranLabReads
Kyle Knouse, Ph.D. retweeted
Chemistry will soon have a new Ψ. Stay tuned. For other Ψ’s, see en.m.wikipedia.org/wiki/Psi_…