Physical Biology of cells & multicellular systems (theory×exp). Chirality, Polarity, Mechanics, Morphogenesis, Collectivity. RIKEN BDR PI @TatsuoShibata25

兵庫 神戸市 中央区
Joined December 2025
Our paper is now out(doi.org/10.1038/s41467-026-7…)! How is chiral info amplified in a multicellular system to form centimeter-scale chiral structures? @hayamas2017 discovered a beautiful multi-armed chiral spiral pattern in Dicty, and @BiplabBhatt1988 developed a model to explain it.
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Our paper is online! doi.org/10.1098/rsif.2026.00… How do invisible mechanical forces deform epithelial tissues during morphogenesis? @GoshiOgita developed Kalman-filter force inference (KFI), extending Bayesian force inference to infer dynamic cellular forces from time-lapse data.
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Our paper is now online! How can we describe active agents—filaments and cells—on curved surfaces? How does curvature affect their collective behavior? We develop a simple geometric framework and show that flocking depends on curvature heterogeneity. doi.org/10.1103/mxgg-9w4l
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New preprint: How is multicellular handedness determined? The same cell chirality can produce opposite multicellular handedness. Just as a car move forward or backward from the same engine rotation. By @TomokiIshibashi, et al. doi.org/10.64898/2026.04.04.…
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It was great to host Robin Bölsterli, a PhD student from the Niels Bohr Institute at the University of Copenhagen. He shared his ongoing collaborative work with Hirashima-san (@hirashima0203), and we had a great discussion.
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We hosted Prof. Stephan Grill (@StephanGrill; MPI-CBG Dresden, @mpicbg, @PoLDresden) for a BDR seminar (@BDR_RIKEN) on Feb 12, followed by a full day of discussions. Thank you, Stephan, for a fantastic talk!
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『現代化学』(@tkd_pbl) 2026年1月号の「FLASH」に寄稿しています。山本さん(@takaki_yamamoto)・石橋さん(@TomokiIshibashi)の論文の紹介です。
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New preprint: Chiral multi-armed spirals emerge in migrating cells under continuous supply. Experiments (Dictyostelium KI)+ an open chiral Vicsek model show how weak single-cell chirality + continuous supply generate macroscopic chiral order. doi.org/10.48550/arXiv.2511.… #ActiveMatter
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