Physical Biology of cells & multicellular systems (theory×exp). Chirality, Polarity, Mechanics, Morphogenesis, Collectivity. RIKEN BDR PI @TatsuoShibata25
兵庫 神戸市 中央区
Joined December 2025
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Our paper is now out(doi.org/10.1038/s41467-026-7…)!
How is chiral info amplified in a multicellular system to form centimeter-scale chiral structures? @hayamas2017 discovered a beautiful multi-armed chiral spiral pattern in Dicty, and @BiplabBhatt1988 developed a model to explain it.
Lab for Physical Biology, RIKEN retweeted
生命のキラリティ研究会に行って参ります...
I’ll be attending the FEBS Workshop “Biochirality across scales” in Nice this week! I’ll be talking about the mechanical principles that bridge cellular and multicellular chirality.
biochirality2026.febsevents.…
#Biochirality #FEBS
Our paper is online! doi.org/10.1098/rsif.2026.00…
How do invisible mechanical forces deform epithelial tissues during morphogenesis? @GoshiOgita developed Kalman-filter force inference (KFI), extending Bayesian force inference to infer dynamic cellular forces from time-lapse data.
研究員の募集
細胞や組織のメカニクスで生まれる生命の秩序に関する理論的研究(riken.jp/careers/researchers…)
細胞や組織のメカニクスに実験的にアプローチ。特に、細胞や多細胞のキラリティ・左右非対称性に関わる研究。(riken.jp/careers/researchers…)
ご興味のある方はお問い合わせください
Open research position in my group at RIKEN BDR, Kobe, Japan.
We seek candidates with a strong background in theoretical biophysics/modeling to study cell and tissue mechanics through close interaction with experiments.
Details:
riken.jp/en/careers/research…
Our paper is now online!
How can we describe active agents—filaments and cells—on curved surfaces? How does curvature affect their collective behavior?
We develop a simple geometric framework and show that flocking depends on curvature heterogeneity. doi.org/10.1103/mxgg-9w4l
Congratulations, Kyogoku-san and Kitajima-san! We are happy to have contributed a theoretical model that helps explain their data on nuclear volume growth.
命の始まりは父母ゲノムの「別居」から
－父母ゲノム間の競合が受精卵の発生を助ける－
doi: doi.org/10.1038/s41586-026-1…
詳細はこちらをご覧ください⬇️
riken.jp/press/2026/20260430…
#理研プレス
New preprint: How is multicellular handedness determined? The same cell chirality can produce opposite multicellular handedness. Just as a car move forward or backward from the same engine rotation. By @TomokiIshibashi, et al. doi.org/10.64898/2026.04.04.…
It was great to host Robin Bölsterli, a PhD student from the Niels Bohr Institute at the University of Copenhagen. He shared his ongoing collaborative work with Hirashima-san (@hirashima0203), and we had a great discussion.
We also contributed.
The study by Yan Chen, @LabPhng and collaborators was published in @NatureComms.
Circumferential actomyosin bundles anchored by CCM1 drive endothelial cell contraction and vessel constriction.
doi.org/10.1038/s41467-025-6…
Lab for Physical Biology, RIKEN retweeted
【オンライン開催📢】
大学院進学希望の皆さん、#連携大学院 の学生として理研で研究してみませんか？
理研生命機能科学研究センター(BDR)で、「連携大学院研究室見学会」の参加者を募集中です。
開催日時：4月11日(土)13:00～
参加方法、詳細⬇️
riken.jp/pr/events/lectures/…
Tatsuo @TatsuoShibata25 will speak at the upcoming EMBL symposium! Looking forward to great discussions on collective behavior in living systems. 次回のEMBLシンポジウムで講演します。生命システムのcollectivityについて議論できるのを楽しみにしています！ #EESCollectivity
@EMBLEvents
We hosted Prof. Stephan Grill (@StephanGrill; MPI-CBG Dresden, @mpicbg, @PoLDresden) for a BDR seminar (@BDR_RIKEN) on Feb 12, followed by a full day of discussions. Thank you, Stephan, for a fantastic talk!
Lab for Physical Biology, RIKEN retweeted
#Molecular #Chirality in cytoskeletal proteins drives cellular rotation, offering new insight into how left–right asymmetry emerges in tissues and organs from the molecular to the cellular level. @riken_en @elife doi.org/hbgmcb phys.org/news/2025-12-chiral…
【arXivプレプリント】細胞やタンパク質が曲面上を動き、集団として秩序化する過程を記述する幾何学的フレームワークを提案しました。曲率とアクティブエージェントのダイナミクスを結び付けます。doi.org/10.48550/arXiv.2512.… #ActiveMatter
New arXiv preprint: I develop a geometric framework to describe how cells and proteins move and collectively organize on curved surfaces, linking curvature to the dynamics of active agents. doi.org/10.48550/arXiv.2512.… #ActiveMatter
【bioRxivプレプリント】Kalman-filter Force Inference（KFI）：上皮形態形成のタイムラプス・イメージングデータから、細胞の力（細胞間接着の張力と細胞圧）を動的にベイズ／カルマンフィルターの枠組みで推定します。doi.org/10.64898/2025.12.19.… #Mechanobiology #Morphogenesis
New bioRxiv preprint: Kalman-filter Force Inference (KFI) estimates dynamic cellular forces (junction tensions and cell pressures) from time-lapse data of epithelial morphogenesis using a Bayesian/Kalman framework. doi.org/10.64898/2025.12.19.… #Mechanobiology #Morphogenesis
New preprint: Chiral multi-armed spirals emerge in migrating cells under continuous supply. Experiments (Dictyostelium KI)+ an open chiral Vicsek model show how weak single-cell chirality + continuous supply generate macroscopic chiral order. doi.org/10.48550/arXiv.2511.… #ActiveMatter