@LabRewitz

We use the model insect Drosophila melanogaster to study totes dope hormonal regulation of growth & development, as well as models of neuropsychatric disorders.

 Copenhagen, Denmark
rewitzlab.dk
Joined July 2019
  • Tweets179
  • Following222
  • Followers542
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This study was supported by @lundbeckfonden, @novonordiskfond, and @Carlsbergfondet — we are grateful for their support. 🙏
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New from our lab in eLife! 🧠 We uncover how gut inflammation signals to the brain through glial JAK–STAT signaling, revealing a cytokine pathway that links intestinal health to sleep. 👉 doi.org/10.7554/eLife.99999

Glia-mediated gut–brain cytokine signaling couples sleep to intestinal inflammatory responses...

Gut-to-brain communication via glial cytokine signaling links intestinal oxidative stress to altered sleep patterns, highlighting how gut inflammation can influence brain function and restorative...

elifesciences.org
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Why do we feel sleepy when sick, and how does gut health affect sleep? 🤒💤 Our new eLife study shows that gut inflammation signals to the brain to trigger sleep. 👉 doi.org/10.7554/eLife.99999 #Neuroscience #SleepResearch #GutBrainAxis

Glia-mediated gut–brain cytokine signaling couples sleep to intestinal inflammatory responses...

Gut-to-brain communication via glial cytokine signaling links intestinal oxidative stress to altered sleep patterns, highlighting how gut inflammation can influence brain function and restorative...

elifesciences.org
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Researchers have discovered a cell surface receptor that is essential for adipose #tissue responding properly to #insulin. When the receptor is inactivated, the response to insulin is insufficient. However, a researcher says that it may be possible to stimulate the receptor – thereby protecting against the #development of type 2 #diabetes. #sciencenewsdk sciencenews.dk/en/recently-d…
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We are thrilled to share that @eLife has now published our "reviewed preprint" on how signaling from the gut to glia connects intestinal inflammation to sleep in #Drosophila! elifesciences.org/reviewed-p… @HalbergLab @Colombani_lab @lundbeckfonden @novonordiskfond @Carlsbergfondet
RewitzLab@LabRewitz10 Jul 2024
We are excited to share our recent work on gut-to-glia communication linking intestinal inflammation with sleep in #Drosophila! Many thanks to @HalbergLab and Andersen and @Colombani_lab! @lundbeckfonden @novonordiskfond @Carlsbergfondet @UCPH_Research biorxiv.org/content/10.1101/…
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Thrilled to share our work! Thanks to @NovoNordiskFond and @DFF_raad, we unveil how LGR signaling mediates crosstalk between muscle, neuronal, and adipose tissues, protecting against #insulinresistance and offering insights into #Diabetes and #Obesity. nature.com/articles/s41467-0…

LGR signaling mediates muscle-adipose tissue crosstalk and protects against diet-induced insulin...

Nature Communications - Obesity induces insulin resistance and impairs insulin signaling, causing diabetes. Here, the authors show that BMP and LGR signaling mediate communication between muscle,...

nature.com
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We are excited to share our recent work on gut-to-glia communication linking intestinal inflammation with sleep in #Drosophila! Many thanks to @HalbergLab and Andersen and @Colombani_lab! @lundbeckfonden @novonordiskfond @Carlsbergfondet @UCPH_Research biorxiv.org/content/10.1101/…
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Latest from the lab: What are the mechanism by which insects maintain systemic ion and water balance as they interact with their environment? Another great collaboration with @DenholmLab!annualreviews.org/eprint/FXM…
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Online now! Glycolysis-derived alanine from glia fuels neuronal mitochondria for memory in Drosophila dlvr.it/SyTZ2L
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Let's try this again - look's like twitter can't handle the video 😂. Really excited to share the lab's first Drosophila paper and it's a big one. Check out our preprint shorturl.at/gqrvO where we present the complete neural connectome of an animal circadian clock
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New paper: Petsakou, A., Liu, Y., Liu, Y. Comjean, A., Hu, Y. and Perrimon, N. Cholinergic neurons trigger epithelial Ca2+ currents to heal the gut. Nature (2023). doi.org/10.1038/s41586-023-0…
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Michael Ashburner (1942-2023). Rubin GM. Curr Biol. 2023 Aug 18:S0960-9822(23)01072-2. doi: 10.1016/j.cub.2023.08.029.
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Our preprint on #Obesity-driven #InsulinResistance reveals a muscle-neuronal-fat axis adapting to high-sugar-induced obesity conditions by influencing insulin secretion & sensitivity in #Drosophila. @Halberglab biorxiv.org/content/10.1101/…

A neuronal relay mediates muscle-adipose communication that drives systemic metabolic adaptation to...

Obesity leads to impaired insulin signaling and tissue sensitivity, which drive the onset of type 2 diabetes. Insulin resistance leads to a reduction in cellular glucose uptake, resulting in elevated...

biorxiv.org
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Our last review: Drosophila TNF/TNFRs: At the crossroad between metabolism, immunity, and tissue homeostasis J. Colombani & D.S. Andersen - FEBS Letters - Wiley Online Library febs.onlinelibrary.wiley.com…

FEBS Press

In this review, we summarize the recent advances in our understanding of how local and systemic sources of TNF contribute to its antitumor and tumor-promoting properties. The recent annotation of...

febs.onlinelibrary.wiley.com
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Curious about how some beetles have evolved to drink, not with their mouths, but with their rectum? Check out our latest Quick Guide in the current issue of @CurrentBiology. In collaboration with @RobinBeaven @DenholmLab sciencedirect.com/science/ar…
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If you are interested in how genes are regulated in response to dietary sugar, please check out our recent publication 'Sugar-responsive inhibition of Myc-dependent ribosome biogenesis by Clockwork orange': cell.com/cell-reports/fullte… 1/

Sugar-responsive inhibition of Myc-dependent ribosome biogenesis by Clockwork orange

van den Berg et al. show that sugar feeding affects several gene expression programs with distinct response kinetics in Drosophila larvae, including transient repression of ribosome biogenesis genes....

cell.com
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How do animals weigh competing needs to maintain nutrient and fluid balance? Check out our recent review in #BioEssays in which we aim to provide a framework for understanding the polymodal optimization of homeostasis in insects. Also, pretty pictures... onlinelibrary.wiley.com/shar…
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Thanks @crisprflydesign! Nice #CRISPR clones showing that the TNF Receptor wgn plays an important role in lipid metabolism in the #Drosophila intestine. science.org/doi/10.1126/scia…
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New paper: split-intein Gal4 provides intersectional genetic labeling that is repressible by Gal80. Ewen-Campen, Luan, Xu, Singh, Joshi, Thakkar, Berger, White, Perrimon. PNAS. 2023 doi: 10.1073/pnas.2304730120. Epub 2023 Jun 5. PMID: 37276389
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New paper: Gut AstA mediates sleep deprivation-induced energy wasting in Drosophila. Li Y, Zhou X, Cheng C, Ding G, Zhao P, Tan K, Chen L, Perrimon N, Veenstra JA, Zhang L, Song W. Cell Discov. 9(1):49. doi: 10.1038/s41421-023-00541-3. PMID: 37221172
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